计划状态
招聘阶段
第二阶段允许先接受免疫治疗
没有CRC 指导的试验
是药物
ABBV-400, Bevacizumab, fluorouracil, Folinic acid, Irinotecan标签
MSS/ MMRp评论
Phase II trial for patients with metastatic CRC who progressed on only one first-line systemic treatment (trial to consider before starting 2nd line treatment for the metastatic setting).
Only for MSS patients, no BRAF mutation allowed.
Combination of a novel agent at different doses, with different combinations of standard of care treatment.
ABBV-400: ADC (antibody-drug conjugate). C -Met–targeting antibody telisotuzumab conjugated to a potent topoisomerase 1 inhibitor (Top1i) payload.
Standard of care drugs used in combinations in this trial: Fluorouracil, Folinic Acid, Bevacizumab
有用链接
https://ascopubs.org/doi/abs/10.1200/JCO.2023.41.16_suppl.3015 PK/PD analyses of circulating tumor DNA (ctDNA) in patients with metastatic colorectal cancer (mCRC) treated with telisotuzumab adizutecan (ABBV-400). Genomic alterations in circulating tumor DNA (ctDNA) and response to telisotuzumab adizutecan (ABBV-400) treatment in patients (pts) with colorectal cancer (CRC). First-in-human study of ABBV-400, a novel c-Met–targeting antibody-drug conjugate, in advanced solid tumors: Results in colorectal cancer. Abstract 6311: ABBV-400: An ADC delivering a novel topoisomerase 1 inhibitor to c-Met-positive solid tumors| 地点 | 位置状态 |
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| 美国 | |
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Mayo Clinic Arizona /ID# 262610 亚利桑那州凤凰城 85054 |
招聘 |
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Highlands Oncology Group, PA /ID# 259424 阿肯色州斯普林代尔 72762 |
已完成 |
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City of Hope National Medical Center /ID# 257576 加利福尼亚州杜阿尔特 91010 |
招聘 |
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City of Hope Orange County Lennar Foundation Cancer Center /ID# 268365 Irvine, California 92618 |
招聘 |
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Yale School of Medicine /ID# 257494 New Haven, Connecticut 06519 |
招聘 |
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Mayo Clinic /ID# 262609 佛罗里达州杰克逊维尔 32224 |
招聘 |
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University of Illinois at Chicago /ID# 257300 Chicago, Illinois 60607 |
招聘 |
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Northwestern University Robert H. Lurie Comprehensive Cancer Center /ID# 260563 Chicago, Illinois 60611-2927 |
招聘 |
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Fort Wayne Medical Oncology and Hematology- South Office /ID# 259601 Fort Wayne, Indiana 46804 |
招聘 |
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Indiana University Melvin and Bren Simon Cancer Center /ID# 258789 Indianapolis, Indiana 46202-5116 |
招聘 |
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Community Health Network, Inc. /ID# 257078 Indianapolis, Indiana 46250-2042 |
招聘 |
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Comprehensive Cancer Centers of Nevada /ID# 257642 Henderson, Louisiana 89052 |
招聘 |
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Mayo Clinic - Rochester /ID# 257301 Rochester, Minnesota 55905-0001 |
招聘 |
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Levine Cancer Institute /ID# 258840 Charlotte, North Carolina 28204 |
招聘 |
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Duke Cancer Center /ID# 257236 Durham, North Carolina 27710-3000 |
招聘 |
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Oregon Health & Science University, Knight Cancer Institute- /ID# 259190 俄勒冈州波特兰 97239 |
招聘 |
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Medical University of South Carolina /ID# 258486 南卡罗来纳州查尔斯顿 29425 |
招聘 |
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Avera Cancer Institute /ID# 257949 Sioux Falls, South Dakota 57105 |
招聘 |
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MD Anderson Cancer Center /ID# 258713 德克萨斯州休斯顿 77030 |
招聘 |
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Millennium Research and Clinical Development /ID# 257780 Houston, Texas 77090-3063 |
招聘 |
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Inova Schar Cancer Institute - Fairfax - Innovation Park Drive /ID# 257448 弗吉尼亚州费尔法克斯 22031 |
招聘 |
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Virginia Cancer Specialists - Fairfax /ID# 257261 弗吉尼亚州费尔法克斯 22031 |
招聘 |
| 比利时 | |
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Imelda Ziekenhuis /ID# 257082 Bonheiden, Antwerpen 2820 |
招聘 |
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Universitair Ziekenhuis Antwerpen /ID# 257080 Edegem, Antwerpen 2650 |
招聘 |
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Cliniques Universitaires UCL Saint-Luc /ID# 257081 Bruxelles, Bruxelles-Capitale 1200 |
招聘 |
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UZ Gent /ID# 257083 Gent, Oost-Vlaanderen 9000 |
招聘 |
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Universitair Ziekenhuis Leuven /ID# 257079 Leuven, Vlaams-Brabant 3000 |
招聘 |
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AZ-Delta /ID# 257084 Roeselare, West-Vlaanderen 8800 |
招聘 |
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Institut Jules Bordet /ID# 257625 Anderlecht 1070 |
招聘 |
| 德国 | |
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Universitatsklinikum Mannheim /ID# 257781 Mannheim, Baden-Wuerttemberg 68167 |
招聘 |
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Universitaetsklinikum Tuebingen /ID# 258780 Tübingen, Baden-Wuerttemberg 72076 |
招聘 |
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Universitaetsklinikum Ulm /ID# 257783 Ulm, Baden-Wuerttemberg 89081 |
招聘 |
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Universitaetsklinikum Carl Gustav Carus Dresden /ID# 257787 Dresden, Sachsen 01307 |
招聘 |
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Charite Universitaetsklinikum Berlin - Campus Virchow /ID# 257785 柏林 13353 |
招聘 |
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Universitaetsklinikum Hamburg-Eppendorf /ID# 257782 汉堡 20246 |
招聘 |
| 以色列 | |
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Rambam Health Care Campus /ID# 257344 Haifa, H_efa 3109601 |
招聘 |
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Meir Medical Center /ID# 257089 Kfar Saba, HaMerkaz 4428164 |
招聘 |
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The Chaim Sheba Medical Center /ID# 257312 Ramat Gan, Tel-Aviv 5265601 |
招聘 |
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Tel Aviv Sourasky Medical Center /ID# 257090 Tel Aviv, Tel-Aviv 6423906 |
招聘 |
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Shaare Zedek Medical Center /ID# 259253 Jerusalem, Yerushalayim 91031 |
招聘 |
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Hadassah /ID# 257088 Jerusalem, Yerushalayim 91120 |
招聘 |
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Assuta Medical Center /ID# 267581 Tel Aviv 6789140 |
招聘 |
| 日本 | |
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Aichi Cancer Center Hospital /ID# 257286 Nagoya-shi, Aichi 464-8681 |
招聘 |
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National Cancer Center Hospital East /ID# 257282 千叶县柏市 277-8577 |
招聘 |
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Kyoto University Hospital /ID# 257287 Kyoto-shi, Kyoto 606-8507 |
招聘 |
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Shizuoka Cancer Center /ID# 257288 静冈县顺藤郡 411-8777 |
招聘 |
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National Cancer Center Hospital /ID# 257284 104-0045 东京都中央区 |
招聘 |
| 大韩民国 | |
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Chonnam National University Hwasun Hospital /ID# 258366 Hwasun-gun, Jeonranamdo 58128 |
招聘 |
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Seoul National University Hospital /ID# 257493 Seoul, Seoul Teugbyeolsi 03080 |
招聘 |
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Asan Medical Center /ID# 257845 Seoul, Seoul Teugbyeolsi 05505 |
招聘 |
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Samsung Medical Center /ID# 257571 Seoul, Seoul Teugbyeolsi 06351 |
招聘 |
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Yonsei University Health System Severance Hospital /ID# 257492 首尔 03722 |
招聘 |
| 西班牙 | |
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Hospital Universitario Vall d'Hebron /ID# 257383 巴塞罗那 08035 |
招聘 |
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Hospital Universitario 12 de Octubre /ID# 257384 马德里 28041 |
招聘 |
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Hospital Universitario HM Sanchinarro /ID# 258549 马德里 28050 |
招聘 |
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Hospital Clinico Universitario de Valencia /ID# 257385 巴伦西亚 46010 |
招聘 |
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Hospital Universitario Miguel Servet /ID# 257388 Zaragoza 50009 |
招聘 |
| 台湾 | |
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Kaohsiung Chang Gung Memorial Hospital /ID# 257675 Kaohsiung City, Kaohsiung 833 |
招聘 |
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National Taiwan University Hospital /ID# 257639 Taipei City, Taipei 100 |
招聘 |
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Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 257637 Kaohsiung 807 |
招聘 |
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National Cheng Kung University Hospital /ID# 257638 Tainan 704 |
招聘 |
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Taipei Veterans General Hosp /ID# 257636 台北 11217 |
招聘 |
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Linkou Chang Gung Memorial Hospital /ID# 257640 Taoyuan City 333 |
招聘 |
联系方式
纳入标准
纳入标准
* Diagnosis of histologically or cytologically confirmed unresectable metastatic colorectal cancer (mCRC).
* Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.
* Progressed on only one first-line (1L) systemic treatment of combination chemotherapy in the metastatic setting with or without targeted therapy.
排除标准
排除标准：
* Harbor the BRAF V600E mutation.
* dMMR+/MSI-H.
* Received anticancer therapy including chemotherapy, radiation therapy, immunotherapy, biologic, or any investigational therapy within 28 days or 5 half-lives of the drug (whichever is shorter) prior to the first dose of ABBV-400.
