MUTYH-ASSOCIATED POLYPOSIS (MAP) Mutations in the MUTYH gene cause MAP. Parents and children of people with MAP are not generally affected by the disease because it has a recessive inheritance pattern. Tell your doctor if you have a family member known to have MAP. It could mean a somewhat higher risk for colon cancer, and earlier, more frequent colonoscopies.

[fusion_builder_container type="flex" hundred_percent="no" equal_height_columns="no" hide_on_mobile="small-visibility,medium-visibility,large-visibility" background_position="center center" background_repeat="no-repeat" fade="no" background_parallax="none" parallax_speed="0.3" video_aspect_ratio="16:9" video_loop="yes" video_mute="yes" border_style="solid"][fusion_builder_row][fusion_builder_column type="1_1" layout="1_1" background_position="left top" border_style="solid" border_position="all" spacing="yes" background_repeat="no-repeat" margin_top="0px" margin_bottom="0px" animation_speed="0.3" animation_direction="left" hide_on_mobile="small-visibility,medium-visibility,large-visibility" center_content="no" last="true" hover_type="none" first="true" background_blend_mode="overlay"][fusion_text]FAMILIAL ADENOMATOUS POLYPOSIS (FAP) AND ATTENUATED FAMILIAL ADENOMATOUS POLYPOSIS (AFAP) The second-most common form of hereditary colorectal cancer is familial adenomatous polyposis (FAP). FAP occurs in one in 10,000 people and is detected by the growth of hundreds to thousands of polyps (adenomas) in the colon, often at an early age. The risk of developing colorectal cancer is 100% if left untreated. Attenuated familial adenomatous polyposis (AFAP) is a milder form of FAP, but still carries a higher risk for colon cancer than the average population. The gene that is associated with both FAP and AFAP is APC (adenomatous polyposis coli).[/fusion_text][fusion_button link="https://fightcolorectalcancer.org/facts/genetics/fap/" target="_self" aria_role_button="0" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" color="custom" button_gradient_top_color_hover="var(--awb-color5)" button_gradient_top_color="var(--awb-color3)" button_gradient_bottom_color_hover="var(--awb-color5)" button_gradient_bottom_color="var(--awb-color3)" linear_angle="180" accent_hover_color="var(--awb-color3)" border_hover_color="var(--awb-color3)" border_color="var(--awb-color3)" stretch="default" icon_position="left" icon_divider="no" hover_transition="text_slide_up" animation_direction="left" animation_speed="0.3" animation_delay="0"]learn more[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]

[fusion_builder_container type="flex" hundred_percent="no" equal_height_columns="no" hide_on_mobile="small-visibility,medium-visibility,large-visibility" background_position="center center" background_repeat="no-repeat" fade="no" background_parallax="none" parallax_speed="0.3" video_aspect_ratio="16:9" video_loop="yes" video_mute="yes" border_style="solid"][fusion_builder_row][fusion_builder_column type="1_1" layout="1_1" background_position="left top" border_style="solid" border_position="all" spacing="yes" background_repeat="no-repeat" margin_top="0px" margin_bottom="0px" animation_speed="0.3" animation_direction="left" hide_on_mobile="small-visibility,medium-visibility,large-visibility" center_content="no" last="true" hover_type="none" first="true"][fusion_text] LYNCH SYNDROME (AKA HEREDITARY NON POLYPOSIS COLON CANCER) Lynch Syndrome is the most common genetic condition linked to colorectal cancer. People with Lynch syndrome are at an increased risk for developing other cancer types and need more frequent screening and surveillance. [/fusion_text][fusion_button link="https://fightcolorectalcancer.org/facts/genetics/lynch-syndrome/" target="_self" aria_role_button="0" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" color="custom" button_gradient_top_color_hover="var(--awb-color5)" button_gradient_top_color="var(--awb-color3)" button_gradient_bottom_color_hover="var(--awb-color5)" button_gradient_bottom_color="var(--awb-color3)" linear_angle="180" accent_hover_color="var(--awb-color3)" accent_color="var(--awb-custom_color_2)" border_hover_color="var(--awb-color3)" border_color="var(--awb-color3)" stretch="default" icon_position="left" icon_divider="no" hover_transition="text_slide_up" animation_direction="left" animation_speed="0.3" animation_delay="0"]read more[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]

没有家族史也会患林奇综合征吗？

虽然这种情况并不常见，但也有可能携带林奇综合征基因突变而没有家族史。在这种情况下，林奇综合征患者被认为是 "新发 "的，或者说是家族中第一个携带这种基因突变的人。

林奇综合征的名字是怎么来的？

Lynch syndrome is named after Dr. Henry Lynch , who devoted his career to studying families that had many people affected with cancer. He described families with Lynch syndrome in the 1970s, at a time when people did not think cancer could be inherited since it isn’t something people are born with. His discoveries have led to increased awareness and prevention of many cancers.

林奇综合征和 HNPCC 是一回事吗？

Hereditary nonpolyposis colorectal cancer, or HNPCC, is often called Lynch syndrome. Although the two hereditary conditions are very similar, what defines them is what makes them different. Lynch syndrome is defined by have a mutation in a MMR gene, whereas family history criteria are used to make a diagnosis of HNPCC.

林奇综合征有症状吗？

Lynch syndrome itself doesn’t come with any symptoms; but the cancers associated come with a variety of symptoms. Make sure you know the symptoms of colorectal cancer, as well as other cancers Lynch involves, like ovarian and endometrial. Knowing your family’s health history is important because you can pay extra attention to your body for any symptoms that may be associated with Lynch cancers.

林奇综合征患者都会得癌症吗？

The diagnosis of a genetic syndrome can be scary, but knowledge is power! The sooner you know if you carry a Lynch syndrome gene, the more aggressive you can be to prevent cancer. Not everyone who is diagnosed with Lynch syndrome will get cancer, but everyone with Lynch syndrome carries a higher risk for certain cancers.

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[fusion_builder_container type="flex" hundred_percent="no" hundred_percent_height="no" hundred_percent_height_scroll="no" align_content="stretch" flex_align_items="flex-start" flex_justify_content="flex-start" flex_wrap="wrap" hundred_percent_height_center_content="yes" equal_height_columns="no" container_tag="div" hide_on_mobile="small-visibility,medium-visibility,large-visibility" status="published" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_position="center center" background_repeat="no-repeat" fade="no" background_parallax="none" enable_mobile="no" parallax_speed="0.3" background_blend_mode="none" background_slider_skip_lazy_loading="no" background_slider_loop="yes" background_slider_pause_on_hover="no" background_slider_slideshow_speed="5000" background_slider_animation="fade" background_slider_direction="up" background_slider_animation_speed="800" video_aspect_ratio="16:9" video_loop="yes" video_mute="yes" pattern_bg="none" pattern_bg_style="default" pattern_bg_opacity="100" pattern_bg_blend_mode="normal" mask_bg="none" mask_bg_style="default" mask_bg_opacity="100" mask_bg_transform="left" mask_bg_blend_mode="normal" absolute="off" absolute_devices="small,medium,large" sticky="off" sticky_devices="small-visibility,medium-visibility,large-visibility" sticky_transition_offset="0" scroll_offset="0" animation_direction="left" animation_speed="0.3" animation_delay="0" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0"][fusion_builder_row][fusion_builder_column type="1_1" layout="1_1" align_self="auto" content_layout="column" align_content="flex-start" valign_content="flex-start" content_wrap="wrap" center_content="no" column_tag="div" target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" order_medium="0" order_small="0" hover_type="none" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" background_type="single" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" lazy_load="avada" background_position="left top" background_repeat="no-repeat" background_blend_mode="none" background_slider_skip_lazy_loading="no" background_slider_loop="yes" background_slider_pause_on_hover="no" background_slider_slideshow_speed="5000" background_slider_animation="fade" background_slider_direction="up" background_slider_animation_speed="800" sticky="off" sticky_devices="small-visibility,medium-visibility,large-visibility" absolute="off" filter_type="regular" filter_hover_element="self" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" transform_type="regular" transform_hover_element="self" transform_scale_x="1" transform_scale_y="1" transform_translate_x="0" transform_translate_y="0" transform_rotate="0" transform_skew_x="0" transform_skew_y="0" transform_scale_x_hover="1" transform_scale_y_hover="1" transform_translate_x_hover="0" transform_translate_y_hover="0" transform_rotate_hover="0" transform_skew_x_hover="0" transform_skew_y_hover="0" transition_duration="300" transition_easing="ease" scroll_motion_devices="small-visibility,medium-visibility,large-visibility" animation_direction="left" animation_speed="0.3" animation_delay="0" last="true" border_position="all" first="true"][fusion_text hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" animation_direction="left" animation_speed="0.3" animation_delay="0"]Our 治疗之路 report is our plan for the future. This plan is not just for Fight CRC, but for everyone who is willing to champion this cause. Together, with our partners, medical experts, and advocates, we work relentlessly to advance progress and eliminate barriers across the colorectal cancer continuum.[/fusion_text][fusion_button link="https://fightcolorectalcancer.org/advocacy/path-to-a-cure/" target="_self" aria_role_button="0" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" color="custom" button_gradient_top_color_hover="var(--awb-color4)" button_gradient_bottom_color_hover="var(--awb-color4)" linear_angle="180" accent_hover_color="var(--awb-color1)" stretch="default" icon_position="left" icon_divider="no" hover_transition="text_slide_up" animation_direction="left" animation_speed="0.3" animation_delay="0" border_hover_color="var(--awb-color1)"]learn more[/fusion_button][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]