计划状态
招聘阶段
第二阶段允许先接受免疫治疗
是CRC 指导的试验
没有药物
Abemaciclib, afatinib, Atezolizumab and PHESGO, Atezolizumab and Talazoparib, Crizotinib, Entrectinib, Larotrectinib, Nivolumab and Ipilimumab, Olaparib, palbociclib, Pembrolizumab, Regorafenib, Sunitinib, Talazoparib, Temsirolimus, Trastuzumab and Pertuzumab, Tucatinib plus Trastuzumab Subcutaneous (SC), Vemurafenib and Cobimetinib, Cotellic, Herceptin, Perjeta, Zelboraf标签
MSI-H/ MMRd、MSS/ MMRp评论
Includes but is not limited to:
HER2 (ERBB2) CRC arm: Participants receive trastuzumab (Herceptin) and pertuzumab (Perjeta)- dosage, frequency and duration per label (ERBB2 (HER2) amplifications)
BRAF CRC arm: Participants receive vemurafenib (BRAF inhibitor, Zelboraf) and cobimetinib (MEK inhibitor, Cotellic) – dosage, frequency and duration per label BRAFV600E mutations
POLE, POLD1 mutations arm: Participants receive pembrolizumab – dosage, frequency and duration per label
Measurable disease is one of the key inclusion criteria.
| 地点 | 位置状态 |
|---|---|
| 美国 | |
|
University of Alabama at Birmingham Comprehensive Cancer Center 阿拉巴马州伯明翰 35294 |
招聘 |
|
Cancer Treatment Centers of America-Phoenix Phoenix, Arizona 85338 |
招聘 |
|
Sutter Auburn Auburn, California 95602 |
招聘 |
|
Sutter Alta Bates Berkeley, California 94705 |
招聘 |
|
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate 加利福尼亚州洛杉矶 90025 |
招聘 |
|
Kaiser Permanente - Oakland Medical Center 加利福尼亚州奥克兰市 94611 |
招聘 |
|
Sutter Palo Alto Medical Foundation: Palo Alto Palo Alto, California 94301 |
招聘 |
|
Kaiser Permanente - Roseville Medical Center 加利福尼亚州罗斯维尔 95661 |
招聘 |
|
Sutter Roseville 加利福尼亚州罗斯维尔 95661 |
招聘 |
|
Kaiser Permanente - Sacramento Medical Center 加利福尼亚州萨克拉门托 95814 |
招聘 |
|
Sutter Sacramento Sacramento, California 95816 |
招聘 |
|
Kaiser Permanente - South San Francisco Medical Center 加利福尼亚州旧金山 94080 |
招聘 |
|
California Pacific Medical Center Research Institute 加利福尼亚州旧金山 94115 |
招聘 |
|
Kaiser Permanente - San Francisco Medical Center 加利福尼亚州旧金山 94115 |
招聘 |
|
Sutter Cancer Research Consortium 加利福尼亚州旧金山 94115 |
招聘 |
|
Kaiser Permanente - San Jose Medical Center 加利福尼亚州圣何塞 95119 |
招聘 |
|
Kaiser Permanente - San Leandro Medical Center 加利福尼亚州圣莱安德罗 94577 |
招聘 |
|
Kaiser Permanente - Santa Clara Medical Center 加利福尼亚州圣克拉拉 95051 |
招聘 |
|
Sutter Palo Alto Medical Foundation: Santa Cruz Santa Cruz, California 95065 |
招聘 |
|
Sutter Palo Alto Medical Foundation: Fremont Santa Cruz, California 994538 |
招聘 |
|
Sutter Palo Alto Medical Foundation: Sunnyvale Sunnyvale, California 94086 |
招聘 |
|
Kaiser Permanente - Vallejo 医疗中心 加利福尼亚州瓦莱约 94589 |
招聘 |
|
Kaiser Permanente - Walnut Creek Medical Center 加利福尼亚州核桃溪 94596 |
招聘 |
|
Saint Vincent's Medical Center (SVMC) Bridgeport, Connecticut 06606 |
招聘 |
|
Hartford Hospital Hartford, Connecticut 06102 |
招聘 |
|
Midstate Medical Center (MSMC) Meriden, Connecticut 06451 |
招聘 |
|
The Hospital of Central Connecticut (HOCC) Cancer Center New Britain, Connecticut 06053 |
招聘 |
|
William W. Backus Hospital Norwich, Connecticut 06360 |
招聘 |
|
Charlotte Hungerford Torrington, Connecticut 06790 |
招聘 |
|
Windham Hospital (WH) Willimantic, Connecticut 06226 |
招聘 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州阿尔塔蒙特斯普林斯 32701 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Bonita Springs, Florida 34135 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Bradenton, Florida 34211 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州布兰登 33511 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Cape Coral, Florida 33909 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州克利尔沃特 33761 |
活跃，非招募 |
|
Holy Cross Hospital Fort Lauderdale, Florida 33308 |
招聘 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute 佛罗里达州迈尔斯堡 33901 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Fort Myers, Florida 33905 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Fort Myers, Florida 33908 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州盖恩斯维尔 32605 |
活跃，非招募 |
|
University of Florida Health 佛罗里达州盖恩斯维尔 32610 |
招聘 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州拉戈 33770 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州莱坎托 34461 |
活跃，非招募 |
|
University of Miami Sylvester Comprehensive Cancer Center 佛罗里达州迈阿密 33136 |
招聘 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Naples, Florida 34102 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州奥卡拉 34474 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州奥兰治市 32763 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州奥兰多 32806 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Port Charlotte, Florida 33980 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州圣彼得堡 33705 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute 佛罗里达州萨拉索塔 34232 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Sarasota, Florida 34236 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州坦帕 33607 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州塔瓦雷斯 32778 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute The Villages, Florida 32159 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州特里尼蒂 34655 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Venice, Florida 34285 |
活跃，非招募 |
|
Florida Cancer Specialists South / Sarah Cannon Research Institute Venice, Florida 34292 |
活跃，非招募 |
|
Florida Cancer Specialists North / Sarah Cannon Research Institute 佛罗里达州温特公园 32789 |
活跃，非招募 |
|
Cancer Treatment Centers of America - Atlanta Atlanta, Georgia 30265 |
招聘 |
|
Emory University Winship Cancer Institute 佐治亚州亚特兰大 30322 |
招聘 |
|
Gynecologic Oncology and Surgical Specialists at the Lewis Cancer & Research Pavilion Savannah, Georgia 31405 |
招聘 |
|
Lewis Cancer & Research Pavilion at the Melanoma, Skin Cancer & Sarcoma Institute Savannah, Georgia 31405 |
招聘 |
|
Lewis Cancer & Research Pavilion Savannah, Georgia 31405 |
招聘 |
|
Summit Cancer Care Savannah, Georgia 31405 |
招聘 |
|
The Queen's Medical Center (The University of Texas MD Anderson Cancer Center) 夏威夷州檀香山 96813 |
活跃，非招募 |
|
Cancer Treatment Centers of America-Chicago Chicago, Illinois 60099 |
招聘 |
|
Community Health Network (The University of Texas MD Anderson Cancer Center) Indianapolis, Indiana 46250 |
招聘 |
|
Harold Alfond Center for Cancer Care Augusta, Maine 04330 |
招聘 |
|
Jackson Laboratory - Maine Cancer Genomics Initiative Augusta, Maine 04330 |
招聘 |
|
Waldo County General Hospital Belfast, Maine 04915 |
招聘 |
|
SMHC Cancer Care and Blood Disorders -Biddeford 缅因州比迪福德 04005 |
招聘 |
|
Northern Light Cancer Care Brewer, Maine 04412 |
招聘 |
|
Raish Peavey Haskell Children's Cancer and Treatment Center Brewer, Maine 04412 |
招聘 |
|
MaineHealth Cancer Care -Brunswick Brunswick, Maine 04011 |
招聘 |
|
New England Cancer Specialist Kennebunk, Maine 04043 |
招聘 |
|
York Hopsital Oncology & Infusion Care in Kittery Kittery, Maine 03904 |
招聘 |
|
Stephens Memorial Hospital Norway, Maine 04268 |
招聘 |
|
Penobscot Bay Medical Center Rockport, Maine 04856 |
招聘 |
|
SMHC Cancer Care and Blood Disorders -Sandford Sanford, Maine 04073 |
招聘 |
|
Maine Children's Cancer Program 缅因州斯卡布罗 04074 |
招聘 |
|
Maine Medical Partner's Women's Health 缅因州斯卡布罗 04074 |
招聘 |
|
New England Cancer Specialist 缅因州斯卡布罗 04074 |
招聘 |
|
MaineHealth Cancer Care -South Portland South Portland, Maine 04106 |
招聘 |
|
New England Cancer Specialist Topsham, Maine 04086 |
招聘 |
|
York Hospital Oncology & Infusion Care in Wells Wells, Maine 04090 |
招聘 |
|
York Hospital Oncology & Infusion Care in York York, Maine 03909 |
招聘 |
|
Trinity Health Ann Arbor Hospital 密歇根州安阿伯市 48106 |
招聘 |
|
密歇根大学 密歇根州安阿伯 48109 |
招聘 |
|
Ascension St. John Hospital Detroit, Michigan 48236 |
招聘 |
|
基因赫利癌症研究所 Grand Blanc, Michigan 48439 |
招聘 |
|
Cancer Research Consortium of West Michigan Grand Rapids, Michigan 49503 |
招聘 |
|
Sparrow Hospital 密歇根州兰辛 48912 |
招聘 |
|
Trinity Health Livonia Hospital 密歇根州利沃尼亚 48154 |
招聘 |
|
Trinity Health Oakland Hospital Pontiac, Michigan 48341 |
招聘 |
|
Ascension St. Mary's Hospital Saginaw, Michigan 48601 |
招聘 |
|
Michigan Cancer Research Consortium Traverse City, Michigan 48341 |
招聘 |
|
St. John Macomb Oakland Hospital Warren, Michigan 48093 |
招聘 |
|
内布拉斯加大学医学中心 内布拉斯加州奥马哈 68198 |
招聘 |
|
NH Oncology - Hematology, PA Concord, New Hampshire 03103 |
招聘 |
|
Solinsky Center for Cancer Care Manchester, New Hampshire 03103 |
招聘 |
|
New England Cancer Specialist Portsmouth, New Hampshire 03801 |
招聘 |
|
Lovelace Medical Center - Saint Joseph Square Albuquerque, New Mexico 87102 |
招聘 |
|
Presbyterian Kaseman Hospital Albuquerque, New Mexico 87110 |
招聘 |
|
The University of New Mexico Comprehensive Cancer Center 新墨西哥州阿尔伯克基 87131 |
招聘 |
|
Memorial Medical Center Las Cruces, New Mexico 88011 |
招聘 |
|
Presbyterian Rust Medical Center Rio Rancho, New Mexico 87124 |
招聘 |
|
Northwell Health Monter Cancer Center 纽约州成功湖 11042 |
招聘 |
|
北韦斯特切斯特医院 纽约州基斯科山 10549 |
招聘 |
|
Cohen Children's Medical Center New Hyde Park, New York 11040 |
招聘 |
|
Herbert Irving Comprehensive Cancer Center 纽约州纽约市 10032 |
招聘 |
|
Manhattan Eye, Ear, and Throat Hospital 纽约州纽约市 10065 |
招聘 |
|
Staten Island University Hospital New York, New York 10305 |
招聘 |
|
Phelps Hospital Sleepy Hollow, New York 10591 |
招聘 |
|
Lineberger Comprehensive Cancer Center 北卡罗来纳州教堂山 27599 |
招聘 |
|
Atrium Health's Levine Cancer Institute Charlotte, North Carolina 28277 |
招聘 |
|
Sanford Health- Bismarck 北达科他州俾斯麦 58501 |
招聘 |
|
Sanford Health- Fargo 北达科他州法戈 58122 |
招聘 |
|
University of Cincinnati Medical Center 俄亥俄州辛辛那提 45219 |
招聘 |
|
Kettering Health 俄亥俄州凯特林 45429 |
招聘 |
|
West Chester Hospital West Chester, Ohio 45069 |
招聘 |
|
Providence Health & Services 俄勒冈州波特兰 97213 |
招聘 |
|
Lehigh Valley Health Network 宾夕法尼亚州阿伦敦 18103 |
招聘 |
|
Lehigh Valley Hospital- Muhlenberg 宾夕法尼亚州伯利恒 18017 |
招聘 |
|
Pocono Medical Center East Stroudsburg, Pennsylvania 18301 |
招聘 |
|
Lehigh Valley Hospital-Hazleton Hazleton, Pennsylvania 18201 |
招聘 |
|
福克斯蔡斯癌症中心 Philadelphia, Pennsylvania 19111 |
招聘 |
|
SC Cancer Specialists at St. Joseph's/Candler Bluffton Bluffton, South Carolina 29910 |
招聘 |
|
St. Joseph's/Candler Smith Bluffton, South Carolina 29910 |
招聘 |
|
Summit Cancer Care at St. Josph's/Candler Bluffton Bluffton, South Carolina 29910 |
招聘 |
|
South Carolina Cancer Specialists Hilton Head Island, South Carolina 29926 |
招聘 |
|
Sanford Cancer Center Oncology Clinic and Pharmacy 南达科他州苏福尔斯 57104 |
招聘 |
|
Tennessee Oncology - Nashville / Sarah Cannon Research Institute 田纳西州纳什维尔 37203 |
招聘 |
|
得克萨斯大学 MD 安德森癌症中心 德克萨斯州休斯顿 77030 |
招聘 |
|
Cedar City Hospital, SW Cancer Clinic, Sandra Maxwell Cancer Center Cedar City, Utah 84720 |
招聘 |
|
Dixie Regional Medical Center-River Road Campus Saint George, Utah 84770 |
招聘 |
|
Intermountain Healthcare Salt Lake City, Utah 84107 |
招聘 |
|
Inova Schar Cancer Institute Fairfax, Virginia 22042 |
招聘 |
|
Swedish Cancer Institute Seattle, Washington 98104 |
招聘 |
|
Aurora Cancer Care - Burlington Burlington, Wisconsin 53105 |
招聘 |
|
Aurora Health Care - Germantown Health Center Germantown, Wisconsin 53022 |
招聘 |
|
Aurora Cancer Care - Grafton Grafton, Wisconsin 53024 |
招聘 |
|
Aurora BayCare Medical Center Green Bay, Wisconsin 54311 |
招聘 |
|
Aurora Cancer Care - Kenosha South Kenosha, Wisconsin 53142 |
招聘 |
|
Aurora Bay Area Medical Center Marinette, Wisconsin 54143 |
招聘 |
|
Aurora Cancer Care Milwaukee Milwaukee, Wisconsin 53209 |
招聘 |
|
Aurora St. Luke's Medical Center Milwaukee, Wisconsin 53215 |
招聘 |
|
Aurora Sinai Medical Center Milwaukee, Wisconsin 53223 |
招聘 |
|
Aurora West Allis Medical Center Milwaukee, Wisconsin 53227 |
招聘 |
|
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin 54904 |
招聘 |
|
Aurora Cancer Care - Racine Racine, Wisconsin 53406 |
招聘 |
|
Vince Lombardi Cancer Center Sheboygan, Wisconsin 53081 |
招聘 |
|
Aurora Medical Center in Summit Summit, Wisconsin 53066 |
招聘 |
|
Vince Lombardi Cancer Clinic - Two Rivers Two Rivers, Wisconsin 54241 |
招聘 |
|
Aurora Cancer Care - Milwaukee West Wauwatosa, Wisconsin 53226 |
招聘 |
联系方式
纳入标准
纳入标准
* 12 years of age or older (*Restrictions apply. Not all therapies are available for patients 9.0 g/dl
3. Platelets > 75,000/µl
4. Total bilirubin < 2.0 mg/ dl, except in patients with Gilbert's Syndrome
5. Aspartate aminotransferase (AST) serum glutamic-oxaloacetic transaminase (SGOT) and alanine aminotransferase (ALT) serum glutamic-pyruvic transaminase (SGPT) < 2.5 x institutional upper limit of normal (ULN) (or < 5 x ULN in patients with known hepatic metastases)
6. Serum creatinine ≤ 1.5 × ULN or calculated or measured creatinine clearance ≥ 50 mL/min/1.73 m2
* Patients must have disease that can be objectively measured by physical or radiographic exam (per RECIST v1.1 for solid tumor, Lugano criteria for non-Hodgkin lymphoma or International Myeloma Working Group criteria for multiple myeloma), defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as ≥20 mm with conventional techniques or as ≥10 mm with spiral CT scan, MRI, or a subcutaneous or superficial lesion that can be measured with calipers by clinical exam. For lymph nodes, the short axis must be ≥15 mm. Patient's whose disease cannot be objectively measured by physical or radiographic examination (e.g., elevated serum tumor marker only, bone-only disease without an identifiable soft tissue component, or patients with only assessable non-measurable disease) are NOT eligible.
* Results must be available from a genomic test or immunohistochemistry (IHC) test for protein expression performed in a Clinical Laboratory Improvement Amendments (CLIA)-certified and College of American Pathologists (CAP)-accredited or New York State accredited (for labs offering services to residents of NY) laboratory. Labs that have registered the test with the NIH Genetic Testing Registry or that provide a report that has been designated as optimized for TAPUR participation are preferred, but not required. The genomic or IHC test used to qualify a patient for participation in TAPUR may have been performed on any specimen of the patient's tumor obtained at any point during the patient's care at the discretion of the patient's treating physician. Genomic assays performed on cell-free DNA in plasma ("liquid biopsies") will also be acceptable if the genomic analysis is performed in a laboratory that meets the criteria described above.
* Ability to understand and the willingness to sign a written informed consent/assent document.
* Have a tumor genomic profile for which single agent treatment with one of the FDA approved targeted anti-cancer drugs included in this study has potential clinical benefit based on the criteria described in protocol.
* For orally administered drugs, the patient must be able to swallow and tolerate oral medication and must have no known malabsorption syndrome.
* Because of the risks of drug treatment to the developing fetus, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of study participation, and for four months following completion of study therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study or if she is the partner of a male participant in this study and becomes pregnant while he is participating in this study, she should inform her or her partner's treating physician immediately as well as her obstetrician. Female study patients who become pregnant must immediately discontinue treatment with any study therapy. Male patients should avoid impregnating a female partner. Male study patients, even if surgically sterilized, (i.e. post-vasectomy) must agree to one of the following: practice effective barrier contraception during the entire study treatment period and for a specified amount of time the last dose of study drug, or completely abstain from sexual intercourse.
Note: TAPUR does not explicitly exclude any type of solid tumor, but the patient must have measurable and evaluable disease per RECIST v1.1.
排除标准
排除标准：
* Patients whose disease is not measurable or cannot be assessed by radiographic imaging or physical examination (e.g., elevated serum tumor marker only) are not eligible
* Patients with primary brain tumors or leptomeningeal metastases are excluded.
* Patients with previously treated brain metastases are eligible, provided that the patient has not experienced a seizure or had a clinically significant change in neurological status within the 3 months prior to registration. All patients with previously treated brain metastases must be clinically stable for at least 1 month after completion of treatment and off steroid treatment for one month prior to study enrollment.
* Patients with known progressive brain metastases are eligible but additional eligibility criteria apply.
Note: there are additional exclusion criteria that may apply
