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Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Program Status

Active, not recruiting

Phase

Phase 3

Prior Immunotherapy Allowed

Yes

CRC-directed Trial

Yes

Drugs

cetuximab, FOLFIRI Regimen, mFOLFOX6 Regimen, MRTX849

Tags

MSI-H/ MMRd, MSS/ MMRp

Helpful Links

Adagrasib With or Without Cetuximab Elicits Responses in Advanced KRAS G12C–Mutated CRC FDA Approves Adagrasib for Locally Advanced or Metastatic KRAS G12C+ NSCLC https://www.nejm.org/doi/full/10.1056/NEJMoa2212419 Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer Adagrasib Plus Cetuximab May Provide Clinical Benefit in Patients With KRASG12C-mutated Colorectal Cancer

Location	Location Status
United States
Local Institution - 010-855-E Alabaster, Alabama 35007	Active, not recruiting
Local Institution - 010-855-B Bessemer, Alabama 35022	Active, not recruiting
Local Institution - 010-855-D Birmingham, Alabama 35209	Active, not recruiting
Local Institution - 010-855-A Birmingham, Alabama 35211	Active, not recruiting
Local Institution - 010-855-F Birmingham, Alabama 35235	Active, not recruiting
Local Institution - 010-855-C Birmingham, Alabama 35243	Active, not recruiting
Local Institution - 010-855 Birmingham, Alabama 35243	Active, not recruiting
Local Institution - 010-996 Gilbert, Arizona 85234	Active, not recruiting
Local Institution - 010-566 Goodyear, Arizona 85338	Active, not recruiting
Local Institution - 010-989 Phoenix, Arizona 85054	Active, not recruiting
Local Institution - 010-978 Springdale, Arkansas 72762	Active, not recruiting
Local Institution - 010-573 Bakersfield, California 93309	Active, not recruiting
Local Institution - 010-979C Chula Vista, California 91911	Active, not recruiting
Local Institution - 010-980 Fresno, California 93701	Active, not recruiting
Local Institution - 010-851 Fullerton, California 92835	Active, not recruiting
Local Institution - 010-979A La Mesa, California 91942	Active, not recruiting
Local Institution - 010-958A Los Angeles, California 90033	Active, not recruiting
Local Institution - 010-958 Los Angeles, California 90033	Active, not recruiting
Local Institution - 010-551 Los Angeles, California 90048	Active, not recruiting
Local Institution - 010-847 Newport Beach, California 92663	Active, not recruiting
Local Institution - 010-563 Redlands, California 92373	Active, not recruiting
Local Institution - 010-979B San Diego, California 92123	Active, not recruiting
Local Institution - 010-979D San Diego, California 92123	Active, not recruiting
Local Institution - 010-979 San Diego, California 92123	Active, not recruiting
Local Institution - 010-982 San Francisco, California 94115	Active, not recruiting
Local Institution - 010-561 Santa Monica, California 90404	Active, not recruiting
Local Institution - 010-571 Sylmar, California 91342	Active, not recruiting
Local Institution - 010-574 Torrance, California 90505	Active, not recruiting
Local Institution - 010-570 Whittier, California 90602	Active, not recruiting
Local Institution - 010-872-H Aurora, Colorado 80012	Active, not recruiting
Local Institution - 010-810 Aurora, Colorado 80045	Active, not recruiting
Local Institution - 010-872-A Boulder, Colorado 80303	Active, not recruiting
Local Institution - 010-872-E Centennial, Colorado 80112	Active, not recruiting
Local Institution - 010-872-C Colorado Springs, Colorado 80907	Active, not recruiting
Local Institution - 010-872 Denver, Colorado 80218	Active, not recruiting
Local Institution - 010-872-B Denver, Colorado 80220	Active, not recruiting
Local Institution - 010-872-J Lakewood, Colorado 80228	Active, not recruiting
Local Institution - 010-872-F Littleton, Colorado 80218	Active, not recruiting
Local Institution - 010-872-G Longmont, Colorado 80501	Active, not recruiting
Local Institution - 010-872-I Pueblo, Colorado 81008	Active, not recruiting
Local Institution - 010-872-D Thornton, Colorado 80260	Active, not recruiting
Local Institution - 010-949 Norwich, Connecticut 06360	Active, not recruiting
Local Institution - 010-922-A Bonita Springs, Florida 34135	Active, not recruiting
Local Institution - 010-922-D Bradenton, Florida 34211	Active, not recruiting
Local Institution - 010-922-E Cape Coral, Florida 33909	Active, not recruiting
Local Institution - 010-922 Fort Myers, Florida 33901	Active, not recruiting
Local Institution - 010-922-B Fort Myers, Florida 33905	Active, not recruiting
Local Institution - 010-922-C Fort Myers, Florida 33908	Active, not recruiting
Local Institution - 010-984-B Holiday, Florida 34691	Active, not recruiting
Local Institution - 010-829 Jacksonville, Florida 32224	Active, not recruiting
Local Institution - 010-923-A Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-B Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-C Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-D Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-E Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-F Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-G Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-H Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-I Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-J Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-K Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-L Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-M Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-N Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-O Largo, Florida 33770	Active, not recruiting
Local Institution - 010-923-P Largo, Florida 33770	Active, not recruiting
Local Institution - 010-990 Miami, Florida 33136	Active, not recruiting
Local Institution - 010-922-F Naples, Florida 34102	Active, not recruiting
Local Institution - 010-922-G Naples, Florida 34102	Active, not recruiting
Local Institution - 010-538 Ocala, Florida 34474	Active, not recruiting
Local Institution - 010-896 Orlando, Florida 32804	Active, not recruiting
Local Institution - 010-988 Orlando, Florida 32806	Active, not recruiting
Local Institution - 010-922-H Port Charlotte, Florida 33980	Active, not recruiting
Local Institution - 010-923 Saint Petersburg, Florida 33705	Active, not recruiting
Local Institution - 010-984 Saint Petersburg, Florida 33709-2236	Active, not recruiting
Local Institution - 010-924 Tallahassee, Florida 32308	Active, not recruiting
Local Institution - 010-984-A Trinity, Florida 34655	Active, not recruiting
Local Institution - 010-926 West Palm Beach, Florida 33401	Active, not recruiting
Local Institution - 010-537 Weston, Florida 33331	Active, not recruiting
Local Institution - 010-956 Atlanta, Georgia 30322	Active, not recruiting
Local Institution - 010-986 Newnan, Georgia 30265	Active, not recruiting
Local Institution - 010-963 Naperville, Illinois 60540	Active, not recruiting
Local Institution - 010-994 Zion, Illinois 60099	Active, not recruiting
Local Institution - 010-569-A Indianapolis, Indiana 46237-8601	Active, not recruiting
Local Institution - 010-569 Indianapolis, Indiana 46237-8601	Active, not recruiting
Local Institution - 010-991 Iowa City, Iowa 52242	Active, not recruiting
Local Institution - 010-920 Baton Rouge, Louisiana 70809	Active, not recruiting
Local Institution - 010-534 Baltimore, Maryland 21201	Active, not recruiting
Local Institution - 010-997 Boston, Massachusetts 02215	Active, not recruiting
Local Institution - 010-531A Brownstown, Michigan 48183	Active, not recruiting
Local Institution - 010-531C Dearborn, Michigan 48126	Active, not recruiting
Local Institution - 010-531 Detroit, Michigan 48202	Active, not recruiting
Local Institution - 010-531B Novi, Michigan 48377	Active, not recruiting
Local Institution - 010-875 Minneapolis, Minnesota 55404	Active, not recruiting
Local Institution - 010-830 Rochester, Minnesota 55905	Active, not recruiting
Local Institution - 010-838 Saint Louis Park, Minnesota 55416	Active, not recruiting
Local Institution - 010-838A Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838B Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838C Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838D Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838E Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838F Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838G Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838H Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838I Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838J Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838K Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838L Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-838M Saint Louis Park, Minnesota 55426	Active, not recruiting
Local Institution - 010-541 Springfield, Missouri 65804	Active, not recruiting
Local Institution - 010-564 Lincoln, Nebraska 68510	Active, not recruiting
Local Institution - 010-590 Omaha, Nebraska 68130	Active, not recruiting
Local Institution - 010-860 - A Henderson, Nevada 89052	Active, not recruiting
Local Institution - 010-860-F Henderson, Nevada 89052	Active, not recruiting
Local Institution - 010-860-B Henderson, Nevada 89074	Active, not recruiting
Local Institution - 010-860-D Las Vegas, Nevada 89128	Active, not recruiting
Local Institution - 010-860-C Las Vegas, Nevada 89144	Active, not recruiting
Local Institution - 010-860-E Las Vegas, Nevada 89148	Active, not recruiting
Local Institution - 010-860 Las Vegas, Nevada 89169	Active, not recruiting
Local Institution - 010-918 - B Basking Ridge, New Jersey 07920	Active, not recruiting
Local Institution - 010-993 Belleville, New Jersey 07109	Active, not recruiting
Local Institution - 010-975 East Brunswick, New Jersey 08816	Active, not recruiting
Local Institution - 010-992 Florham Park, New Jersey 07932	Active, not recruiting
Local Institution - 010-918 - D Middletown, New Jersey 07748	Active, not recruiting
Local Institution - 010-918 - C Montvale, New Jersey 07645	Active, not recruiting
Local Institution - 010-957 New Brunswick, New Jersey 08903-2681	Active, not recruiting
Local Institution - 010-535 - D Babylon, New York 11702	Active, not recruiting
Local Institution - 010-535 - E Bronx, New York 10469	Active, not recruiting
Local Institution - 010-918 - A Commack, New York 11725	Active, not recruiting
Local Institution - 010-918 - F Harrison, New York 10604	Active, not recruiting
Local Institution - 010-813 New York, New York 10016	Active, not recruiting
Local Institution - 010-535 - G New York, New York 10028	Active, not recruiting
Local Institution - 010-998 New York, New York 10029	Active, not recruiting
Local Institution - 010-918 New York, New York 10065	Active, not recruiting
Local Institution - 010-535 - C Patchogue, New York 11772	Active, not recruiting
Local Institution - 010-535 - B Port Jefferson Station, New York 11776	Active, not recruiting
Local Institution - 010-535 - A Port Jefferson, New York 11776	Active, not recruiting
Local Institution - 010-535 - F Riverhead, New York 11901	Active, not recruiting
Local Institution - 010-535 Shirley, New York 11967	Active, not recruiting
Local Institution - 010-918 - E Uniondale, New York 11553	Active, not recruiting
Local Institution - 010-585-B Clinton, North Carolina 28328	Active, not recruiting
Local Institution - 010-585 Goldsboro, North Carolina 27534	Active, not recruiting
Local Institution - 010-585-A Jacksonville, North Carolina 28546	Active, not recruiting
Local Institution - 010-893 Cincinnati, Ohio 45211	Active, not recruiting
Local Institution - 010-532 Oklahoma City, Oklahoma 73104	Active, not recruiting
Local Institution - 010-549 Oklahoma City, Oklahoma 73120	Active, not recruiting
Local Institution - 010-584 Tulsa, Oklahoma 74146	Active, not recruiting
Local Institution - 010-596 Pittsburgh, Pennsylvania 15212	Active, not recruiting
Local Institution - 010-981 Greenville, South Carolina 29607	Active, not recruiting
Local Institution - 010-921 Chattanooga, Tennessee 37404	Active, not recruiting
Local Institution - 010-801 Nashville, Tennessee 37203	Active, not recruiting
Local Institution - 010-572 Dallas, Texas 75216	Active, not recruiting
Local Institution - 010-879 Dallas, Texas 75246	Active, not recruiting
Local Institution - 010-577-B Houston, Texas 77008	Active, not recruiting
Local Institution - 010-577-A Houston, Texas 77024	Active, not recruiting
Local Institution - 010-577 Houston, Texas 77030	Active, not recruiting
Local Institution - 010-848 Houston, Texas 77030	Active, not recruiting
Local Institution - 010-977 Houston, Texas 77090	Active, not recruiting
Local Institution - 010-999 Irving, Texas 75063	Active, not recruiting
Local Institution - 010-878-B Longview, Texas 75601	Active, not recruiting
Local Institution - 010-862 San Antonio, Texas 78240	Active, not recruiting
Local Institution - 010-964 Temple, Texas 76508	Active, not recruiting
Local Institution - 010-878 Tyler, Texas 75702	Active, not recruiting
Local Institution - 010-976-F American Fork, Utah 84003	Active, not recruiting
Local Institution - 010-976-C Bountiful, Utah 84010	Active, not recruiting
Local Institution - 010-976-D Layton, Utah 84041	Active, not recruiting
Local Institution - 010-976-A Murray, Utah 84157	Active, not recruiting
Local Institution - 010-976-H Ogden, Utah 84405	Active, not recruiting
Local Institution - 010-976-G Provo, Utah 84604	Active, not recruiting
Local Institution - 010-976-B Salt Lake City, Utah 84102	Active, not recruiting
Local Institution - 010-976 Salt Lake City, Utah 84106	Active, not recruiting
Local Institution - 010-976-E West Jordan, Utah 84088	Active, not recruiting
Local Institution - 010-919 Fairfax, Virginia 22031-4630	Active, not recruiting
Local Institution - 010-597 Fredericksburg, Virginia 24408	Active, not recruiting
Local Institution - 010-539 Richmond, Virginia 23229	Active, not recruiting
Local Institution - 010-536 Richmond, Virginia 23298	Active, not recruiting
Local Institution - 010-533 A Auburn, Washington 98001	Active, not recruiting
Local Institution - 010-576 Everett, Washington 98201	Active, not recruiting
Local Institution - 010-533 B Gig Harbor, Washington 98335	Active, not recruiting
Local Institution - 010-533 C Puyallup, Washington 98372	Active, not recruiting
Local Institution - 010-824 Seattle, Washington 98109--1023	Active, not recruiting
Local Institution - 010-533 Tacoma, Washington 98405	Active, not recruiting
Local Institution - 010-885 Vancouver, Washington 98684	Active, not recruiting
Local Institution - 010-575 Morgantown, West Virginia 26506-9300	Active, not recruiting
Local Institution - 010-947 Milwaukee, Wisconsin 53226	Active, not recruiting
Argentina
Local Institution - 010-434 Buenos Aires C1426ANZ	Active, not recruiting
Local Institution - 010-431 Buenos Aires CI264 AAA	Active, not recruiting
Local Institution - 010-432 Caba 1061	Active, not recruiting
Local Institution - 010-430 La Rioja F5300COE	Active, not recruiting
Local Institution - 010-448 Porto Alegre 91350-200	Active, not recruiting
Local Institution - 010-433 Viedma R8500ACE	Active, not recruiting
Australia
Local Institution - 010-005 Bedford Park 5042	Active, not recruiting
Local Institution - 010-004 Clayton 3168	Active, not recruiting
Local Institution - 010-006 Garran 2065	Active, not recruiting
Local Institution - 010-015 Heidelberg 3084	Active, not recruiting
Local Institution - 010-012 Melbourne 3004	Active, not recruiting
Local Institution - 010-002 Waratah 2298	Active, not recruiting
Austria
Local Institution - 010-145 Innsbruck 6020	Active, not recruiting
Local Institution - 010-143 Wiener Neustadt 2700	Active, not recruiting
Local Institution - 010-144 Wien 1090	Active, not recruiting
Belgium
Local Institution - 010-154 Brussel 1090	Active, not recruiting
Local Institution - 010-157 Edegem 2650	Active, not recruiting
Local Institution - 010-156 Gent 9000	Active, not recruiting
Local Institution - 010-150 Yvoir B-5530	Active, not recruiting
Brazil
Local Institution - 010-446 Ijui, Rio Grande Do Sul 98700-000	Active, not recruiting
Local Institution - 010-443 Porto Alegre, Rio Grande Do Sul 90035-903	Active, not recruiting
Local Institution - 010-450 Blumenau, Santa Catarina 89010-340	Active, not recruiting
Local Institution - 010-442 Curitiba 80040-170	Active, not recruiting
Local Institution - 010-449 Liberdade 01509-010	Active, not recruiting
Local Institution - 010-444 Santo Andre 09060-650	Active, not recruiting
Local Institution - 010-440 Sao Jose do Rio Preto 15090-000	Active, not recruiting
Local Institution - 010-441 Sao Paolo 01246-000	Active, not recruiting
Local Institution - 010-445 Sao Paulo 01323-030	Active, not recruiting
Local Institution - 010-447 Sao Paulo 04543-000	Active, not recruiting
Canada
Local Institution - 010-481 Ottawa, Ontario K1H 8L6	Active, not recruiting
Local Institution - 010-483 Toronto, Ontario M5B 1W8	Active, not recruiting
Local Institution - 010-482 Toronto, Ontario M5G 2M9	Active, not recruiting
Local Institution - 010-487 Montreal, Quebec H1T 2M4	Active, not recruiting
China
Local Institution - 010-712 Bengbu, Anhui 233004	Active, not recruiting
Local Institution - 010-026 Hefei Shi, Anhui 230001	Active, not recruiting
Local Institution - 010-022 Hefei, Anhui 230022	Active, not recruiting
Local Institution - 010-711 Hefei, Anhui 230031	Active, not recruiting
Local Institution - 010-717 Beijing, Beijing 100021	Active, not recruiting
Local Institution - 010-029 Fuzhou, Fujian 350014	Active, not recruiting
Local Institution - 010-031 Guangzhou, Guangdong 510655	Active, not recruiting
Local Institution - 010-713 Shenzhen, Guangdong 518036	Active, not recruiting
Local Institution - 010-715 Nanning, Guangxi 530021	Active, not recruiting
Local Institution - 010-021 Zhengzhou City, Henan 450008	Active, not recruiting
Local Institution - 010-703 Wuhan, Hubei 430030	Active, not recruiting
Local Institution - 010-701 Wuhan, Hubei 430079	Active, not recruiting
Local Institution - 010-035 Changsha, Hunan 410008	Active, not recruiting
Local Institution - 010-714 Jiangyin, Jiangsu 214400	Active, not recruiting
Local Institution - 010-704 Nanjing, Jiangsu 210029	Active, not recruiting
Local Institution - 010-706 Nanchang, Jiangxi 330006	Active, not recruiting
Local Institution - 010-030 Changchun, Jilin 130012	Active, not recruiting
Local Institution - 010-718 Changchun, Jilin 130021	Active, not recruiting
Local Institution - 010-709 Shenyang, Liaoning 110001	Active, not recruiting
Local Institution - 010-705 Shenyang, Liaoning 110042	Active, not recruiting
Local Institution - 010-036 Jinan, Shandong 250117	Active, not recruiting
Local Institution - 010-025 Shanghai Shi, Shanghai 200025	Active, not recruiting
Local Institution - 010-024 Shanghaishi, Shanghai 200032	Active, not recruiting
Local Institution - 010-038 Shanghai, Shanghai 200080	Active, not recruiting
Local Institution - 010-020 Shanghai, Shanghai 200120	Active, not recruiting
Local Institution - 010-708 Shanghai, Shanghai 200240	Active, not recruiting
Local Institution - 010-710 Chengdu, Sichuan 610044	Active, not recruiting
Local Institution - 010-716 Neijiang, Sichuan 641199	Active, not recruiting
Local Institution - 010-027 Tianjin, Tianjin 300060	Active, not recruiting
Local Institution - 010-707 Hangzhou, Zhejiang 310009	Active, not recruiting
Local Institution - 010-034 Hangzhou, Zhejiang 310022	Active, not recruiting
Local Institution - 010-032 Hangzhou 310016	Active, not recruiting
Local Institution - 010-033 Hongkou Qu 200080	Active, not recruiting
Colombia
Local Institution - 010-460 Barranquilla 080020	Active, not recruiting
Local Institution - 010-462 Bogota 0	Active, not recruiting
Local Institution - 010-465 Floridablanca 0	Active, not recruiting
Local Institution - 010-463 Medellin 050034	Active, not recruiting
Czechia
Local Institution - 010-165 Brno 656 53	Active, not recruiting
Local Institution - 010-160 Brno 656 91	Active, not recruiting
Local Institution - 010-162 Olomouc 779 00	Active, not recruiting
Local Institution - 010-161 Praha 5 150 06	Active, not recruiting
Denmark
Local Institution - 010-171 Copenhagen 2100	Active, not recruiting
Local Institution - 010-172 Odense 5000	Active, not recruiting
Local Institution - 010-170 Vejle 7100	Active, not recruiting
Finland
Local Institution - 010-180 Helsinki FI-00029	Active, not recruiting
Local Institution - 010-182 Tampere 33520	Active, not recruiting
Local Institution - 010-181 Turku 20521	Active, not recruiting
France
Local Institution - 010-209-A Chambray-les-Tours, Centre-Val De Loire 37170	Active, not recruiting
Local Institution - 010-668 Avignon 84918	Active, not recruiting
Local Institution - 010-208 Besancon 25000	Active, not recruiting
Local Institution - 010-669 Bordeaux 33000	Active, not recruiting
Local Institution - 010-194 Brest 29200	Active, not recruiting
Local Institution - 010-192 Dijon cedex 21079	Active, not recruiting
Local Institution - 010-662 Lille 59037	Active, not recruiting
Local Institution - 010-205 Lyon 69008	Active, not recruiting
Local Institution - 010-682 Marseille Cedex 5 13005	Active, not recruiting
Local Institution - 010-203 Paris Cedex 12 75012	Active, not recruiting
Local Institution - 010-207 Paris 75010	Active, not recruiting
Local Institution - 010-204 Paris 75013	Active, not recruiting
Local Institution - 010-661 Paris 75015	Active, not recruiting
Local Institution - 010-660 Pessac 33720	Active, not recruiting
Local Institution - 010-667 Suresnes 92150	Active, not recruiting
Local Institution - 010-680 Toulouse cedex 9 31059	Active, not recruiting
Local Institution - 010-209 Tours Cedex 9 37044	Active, not recruiting
Local Institution - 010-202 Villejuif 94805	Active, not recruiting
Germany
Local Institution - 010-675 Amberg 92224	Active, not recruiting
Local Institution - 010-657 Berlin 10117	Active, not recruiting
Local Institution - 010-655 Bochum 44791	Active, not recruiting
Local Institution - 010-227 Dresden 01307	Active, not recruiting
Local Institution - 010-229 Frankfurt am Main 60488	Active, not recruiting
Local Institution - 010-656 Hamburg D-20249	Active, not recruiting
Local Institution - 010-658 Herne 44625	Active, not recruiting
Local Institution - 010-228 Monchengladbach 41063	Active, not recruiting
Local Institution - 010-650 Munchen 81377	Active, not recruiting
Local Institution - 010-226 Munchen 81737	Active, not recruiting
Local Institution - 010-652 Reutlingen 72764	Active, not recruiting
Local Institution - 010-676 Ulm 89081	Active, not recruiting
Greece
Local Institution - 010-501 Athens 11528	Active, not recruiting
Local Institution - 010-232 Cholargos 155 62	Active, not recruiting
Local Institution - 010-238 Heraklion 71110	Active, not recruiting
Local Institution - 010-235 Larissa 41110	Active, not recruiting
Local Institution - 010-231 Thessaloniki 54645	Active, not recruiting
Local Institution - 010-230 Thessaloniki 57001	Active, not recruiting
Hong Kong
Local Institution - 010-048 Central 0	Active, not recruiting
Local Institution - 010-046 Hong Kong 0	Active, not recruiting
Ireland
Local Institution - 010-250 Dublin 4	Active, not recruiting
Local Institution - 010-252 Dublin 9	Active, not recruiting
Local Institution - 010-253 Dublin D07 R2WY	Active, not recruiting
Local Institution - 010-254 Dublin D07 WKW8	Active, not recruiting
Local Institution - 010-251 Dublin D24 NR0A	Active, not recruiting
Italy
Local Institution - 010-292 Avellino 83100	Active, not recruiting
Local Institution - 010-290 Biella 13875	Active, not recruiting
Local Institution - 010-299 Cagliari 9042	Active, not recruiting
Local Institution - 010-286 Candiolo 10060	Active, not recruiting
Local Institution - 010-287 Lido di Camaiore 55041	Active, not recruiting
Local Institution - 010-270 Meldola 47014	Active, not recruiting
Local Institution - 010-293 Milano 20162	Active, not recruiting
Local Institution - 010-278 Milan 20141	Active, not recruiting
Local Institution - 010-271 Napoli 80131	Active, not recruiting
Local Institution - 010-297 Padova 35128	Active, not recruiting
Local Institution - 010-294 Pisa 56126	Active, not recruiting
Local Institution - 010-291 Reggio Emilia 42100	Active, not recruiting
Local Institution - 010-295 Roma 00144	Active, not recruiting
Local Institution - 010-289 Torino 10128	Active, not recruiting
Korea, Republic of
Local Institution - 010-116 Anyang-si 14068	Active, not recruiting
Local Institution - 010-111 Busan 48108	Active, not recruiting
Local Institution - 010-119 Busan 602-812	Active, not recruiting
Local Institution - 010-525 Daejeon 35015	Active, not recruiting
Local Institution - 010-117 Goyang-si 10408	Active, not recruiting
Local Institution - 010-100 Hwasun-gun 58128	Active, not recruiting
Local Institution - 010-520 Seongnam-si 13496	Active, not recruiting
Local Institution - 010-105 Seoul 02841	Active, not recruiting
Local Institution - 010-108 Seoul 03080	Active, not recruiting
Local Institution - 010-118 Seoul 03722	Active, not recruiting
Local Institution - 010-104 Seoul 05505	Active, not recruiting
Local Institution - 010-114 Seoul 06351	Active, not recruiting
Local Institution - 010-109 Seoul 06591	Active, not recruiting
Local Institution - 010-115 Suwon-Si 16247	Active, not recruiting
Local Institution - 010-524 Yangsan-si 50612	Active, not recruiting
Malaysia
Local Institution - 010-070 Johor Bahru, Johor 81100	Active, not recruiting
Local Institution - 010-077 Kota Kinabalu, Sabah 88996	Active, not recruiting
Local Institution - 010-071 Petaling Jaya, Selangor 46050	Active, not recruiting
Local Institution - 010-073 Kuala Lumpur 50586	Active, not recruiting
Local Institution - 010-074 Kuala Lumpur 50603	Active, not recruiting
Local Institution - 010-072 Putrajaya 62250	Active, not recruiting
Mexico
Local Institution - 010-474 Tuxtla Gutierrez, Chiapas 29038	Active, not recruiting
Local Institution - 010-473 Mexico City, Distrito Federal 14080	Active, not recruiting
Local Institution - 010-472 Guadalajara, Jalisco 44280	Active, not recruiting
Local Institution - 010-477 Guadalajara, Jalisco 44670	Active, not recruiting
Local Institution - 010-476 Cuernavaca, Morelos 62290	Active, not recruiting
Local Institution - 010-475 San Juan del Rio, Queretaro 76800	Active, not recruiting
Local Institution - 010-471 Colonia Centro Orizaba, Veracruz 94300	Active, not recruiting
Netherlands
Local Institution - 010-632 Amsterdam 1066 CX	Active, not recruiting
Local Institution - 010-306 Amsterdam 1081 HV	Active, not recruiting
Local Institution - 010-630 Nijmegen 6525 GA	Active, not recruiting
Local Institution - 010-307 Utrecht 3543 AZ	Active, not recruiting
Poland
Local Institution - 010-328 Gdansk 80-219	Active, not recruiting
Local Institution - 010-327 Otwock 05-400	Active, not recruiting
Local Institution - 010-322 Warszawa 02-034	Active, not recruiting
Local Institution - 010-787 Warszawa 02-507	Active, not recruiting
Portugal
Local Institution - 010-332 Braga 4710-243	Active, not recruiting
Local Institution - 010-337 Lisbon 1400-038	Active, not recruiting
Local Institution - 010-640 Lisbon 1649-035	Active, not recruiting
Local Institution - 010-331 Porto 4099-001	Active, not recruiting
Local Institution - 010-339 Porto 4200-072	Active, not recruiting
Puerto Rico
Local Institution - 010-902 San Juan 00919	Active, not recruiting
Local Institution - 010-903 San Juan 00927	Active, not recruiting
Local Institution - 010-900 San Juan 00935	Active, not recruiting
Romania
Local Institution - 010-347 Baia Mare 430031	Active, not recruiting
Local Institution - 010-349 Brasov 500152	Active, not recruiting
Local Institution - 010-512 Bucharest 022328	Active, not recruiting
Local Institution - 010-344 Cluj-Napoca 400015	Active, not recruiting
Local Institution - 010-340 Cluj-Napoca 400641	Active, not recruiting
Local Institution - 010-343 Craiova 200746	Active, not recruiting
Local Institution - 010-511 Ovidiu 905900	Active, not recruiting
Local Institution - 010-510 Timisoara 300239	Active, not recruiting
Singapore
Local Institution - 010-090 Singapore 119074	Active, not recruiting
Local Institution - 010-093 Singapore 168583	Active, not recruiting
Local Institution - 010-095 Singapore 188770	Active, not recruiting
Local Institution - 010-092 Singapore 217562	Active, not recruiting
Local Institution - 010-091 Singapore 258499	Active, not recruiting
Spain
Local Institution - 010-613 A Coruna 15006	Active, not recruiting
Local Institution - 010-610 Badalona 08916	Active, not recruiting
Local Institution - 010-612 Barcelona 08035	Active, not recruiting
Local Institution - 010-600 Barcelona 08036	Active, not recruiting
Local Institution - 010-621 Cordoba 14004	Active, not recruiting
Local Institution - 010-620 LHospitalet de Llobregat 08908	Active, not recruiting
Local Institution - 010-619 Madrid 28007	Active, not recruiting
Local Institution - 010-601 Madrid 28040	Active, not recruiting
Local Institution - 010-617 Madrid 28041	Active, not recruiting
Local Institution - 010-624 Madrid 28046	Active, not recruiting
Local Institution - 010-623 Pamplona 31008	Active, not recruiting
Local Institution - 010-622 Sabadell 08208	Active, not recruiting
Local Institution - 010-604 Santander 39008	Active, not recruiting
Local Institution - 010-618 Valencia 46010	Active, not recruiting
Local Institution - 010-625 Valencia 46014	Active, not recruiting
Taiwan
Local Institution - 010-129 Changhua City 500	Active, not recruiting
Local Institution - 010-121 Kaohsiung 807	Active, not recruiting
Local Institution - 010-124 Taichung 40705	Active, not recruiting
Local Institution - 010-123 Tainan City 73657	Active, not recruiting
Local Institution - 010-122 Tainan 704	Active, not recruiting
Local Institution - 010-120 Taipei City 10002	Active, not recruiting
Local Institution - 010-125 Taoyuan 333	Active, not recruiting
Thailand
Local Institution - 010-132 Bang Phlat 10700	Active, not recruiting
Local Institution - 010-134 Bangkok 10400	Active, not recruiting
Local Institution - 010-131 Chiang Mai 50200	Active, not recruiting
Local Institution - 010-130 Hat Yai 90110	Active, not recruiting
Local Institution - 010-133 Khlong Toey 10110	Active, not recruiting
Ukraine
Local Institution - 010-424 Sumy 40022	Active, not recruiting
United Kingdom
Local Institution - 010-412 Aberdeen AB25 2ZN	Active, not recruiting
Local Institution - 010-410 Birmingham B15 2WB	Active, not recruiting
Local Institution - 010-413 Cambridge CB2 0QQ	Active, not recruiting
Local Institution - 010-411 Dorset BH7 7DW	Active, not recruiting
Local Institution - 010-400 Glasgow G12 0XH	Active, not recruiting
Local Institution - 010-403 Kent ME16 9QQ	Active, not recruiting
Local Institution - 010-414 Leeds LS9 7TF	Active, not recruiting
Local Institution - 010-402 London NW1 2BU	Active, not recruiting
Local Institution - 010-405 London SW3 6JJ	Active, not recruiting
Local Institution - 010-406 London SW3 6JJ	Active, not recruiting
Local Institution - 010-407 Manchester M20 4BX	Active, not recruiting
Local Institution - 010-404 Middlesex HA6 2RN	Active, not recruiting

Inclusion Criteria

Inclusion Criteria:

* Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
* Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria

Exclusion Criteria:

* Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
* Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
* Active brain metastasis

NCT ID

NCT04793958

Date Trial Added

2021-03-11

Updated Date

2025-03-25