Program Status
SuspendedPhase
Phase 3Prior Immunotherapy Allowed
NoCRC-directed Trial
YesDrugs
Atezolizumab, fluorouracil, Leucovorin, oxaliplatinTags
MSI-H/ MMRd| Location | Location Status |
|---|---|
| United States | |
|
Kingman Regional Medical Center Kingman, Arizona 86401 |
Suspended |
|
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas 72401 |
Suspended |
|
Kaiser Permanente-Anaheim Anaheim, California 92806 |
Suspended |
|
Kaiser Permanente-Baldwin Park Baldwin Park, California 91706 |
Suspended |
|
Kaiser Permanente-Bellflower Bellflower, California 90706 |
Suspended |
|
Alta Bates Summit Medical Center-Herrick Campus Berkeley, California 94704 |
Suspended |
|
John Muir Medical Center-Concord Concord, California 94520 |
Suspended |
|
Kaiser Permanente-Fontana Fontana, California 92335 |
Suspended |
|
Kaiser Permanente South Bay Harbor City, California 90710 |
Suspended |
|
Kaiser Permanente-Irvine Irvine, California 92618 |
Suspended |
|
Kaiser Permanente Los Angeles Medical Center Los Angeles, California 90027 |
Suspended |
|
Kaiser Permanente West Los Angeles Los Angeles, California 90034 |
Suspended |
|
Fremont - Rideout Cancer Center Marysville, California 95901 |
Suspended |
|
Memorial Medical Center Modesto, California 95355 |
Suspended |
|
Kaiser Permanente-Ontario Ontario, California 91761 |
Suspended |
|
Saint Joseph Hospital - Orange Orange, California 92868 |
Suspended |
|
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California 92868 |
Suspended |
|
Kaiser Permanente - Panorama City Panorama City, California 91402 |
Suspended |
|
Kaiser Permanente-Riverside Riverside, California 92505 |
Suspended |
|
Sutter Medical Center Sacramento Sacramento, California 95816 |
Suspended |
|
University of California Davis Comprehensive Cancer Center Sacramento, California 95817 |
Suspended |
|
Salinas Valley Memorial Salinas, California 93901 |
Suspended |
|
Kaiser Permanente-San Diego Mission San Diego, California 92108 |
Suspended |
|
Kaiser Permanente-San Diego Zion San Diego, California 92120 |
Suspended |
|
Kaiser Permanente-San Marcos San Marcos, California 92078 |
Suspended |
|
John Muir Medical Center-Walnut Creek Walnut Creek, California 94598 |
Suspended |
|
Presbyterian Intercommunity Hospital Whittier, California 90602 |
Suspended |
|
Kaiser Permanente-Woodland Hills Woodland Hills, California 91367 |
Suspended |
|
Rocky Mountain Cancer Centers-Aurora Aurora, Colorado 80012 |
Suspended |
|
UCHealth University of Colorado Hospital Aurora, Colorado 80045 |
Suspended |
|
Boulder Community Hospital Boulder, Colorado 80301 |
Suspended |
|
Rocky Mountain Cancer Centers-Boulder Boulder, Colorado 80304 |
Suspended |
|
Penrose-Saint Francis Healthcare Colorado Springs, Colorado 80907 |
Suspended |
|
UCHealth Memorial Hospital Central Colorado Springs, Colorado 80909 |
Suspended |
|
Memorial Hospital North Colorado Springs, Colorado 80920 |
Suspended |
|
Denver Health Medical Center Denver, Colorado 80204 |
Suspended |
|
National Jewish Health-Main Campus Denver, Colorado 80206 |
Suspended |
|
AdventHealth Porter Denver, Colorado 80210 |
Suspended |
|
Rocky Mountain Cancer Centers-Midtown Denver, Colorado 80218 |
Suspended |
|
Saint Joseph Hospital - Cancer Centers of Colorado Denver, Colorado 80218 |
Suspended |
|
Rocky Mountain Cancer Centers-Rose Denver, Colorado 80220 |
Suspended |
|
Mountain Blue Cancer Care Center - Swedish Englewood, Colorado 80113 |
Suspended |
|
Swedish Medical Center Englewood, Colorado 80113 |
Suspended |
|
Poudre Valley Hospital Fort Collins, Colorado 80524 |
Suspended |
|
Cancer Care and Hematology-Fort Collins Fort Collins, Colorado 80528 |
Suspended |
|
National Jewish Health-Western Hematology Oncology Golden, Colorado 80401 |
Suspended |
|
Banner North Colorado Medical Center Greeley, Colorado 80631 |
Suspended |
|
UCHealth Greeley Hospital Greeley, Colorado 80631 |
Suspended |
|
Rocky Mountain Cancer Centers-Littleton Littleton, Colorado 80120 |
Suspended |
|
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado 80124 |
Suspended |
|
Medical Center of the Rockies Loveland, Colorado 80538 |
Suspended |
|
Banner McKee Medical Center Loveland, Colorado 80539 |
Suspended |
|
National Jewish Health-Northern Hematology Oncology Thornton, Colorado 80260 |
Suspended |
|
Intermountain Health Lutheran Hospital Wheat Ridge, Colorado 80401 |
Suspended |
|
Danbury Hospital Danbury, Connecticut 06810 |
Suspended |
|
Hartford Hospital Hartford, Connecticut 06102 |
Suspended |
|
Midstate Medical Center Meriden, Connecticut 06451 |
Suspended |
|
The Hospital of Central Connecticut New Britain, Connecticut 06050 |
Suspended |
|
William Backus Hospital Norwich, Connecticut 06360 |
Suspended |
|
Beebe South Coastal Health Campus Millville, Delaware 19967 |
Suspended |
|
Helen F Graham Cancer Center Newark, Delaware 19713 |
Suspended |
|
Medical Oncology Hematology Consultants PA Newark, Delaware 19713 |
Suspended |
|
Beebe Health Campus Rehoboth Beach, Delaware 19971 |
Suspended |
|
Kaiser Permanente-Capitol Hill Medical Center Washington, District of Columbia 20002 |
Suspended |
|
Broward Health Medical Center Fort Lauderdale, Florida 33316 |
Suspended |
|
Regional Cancer Center-Lee Memorial Health System Fort Myers, Florida 33905 |
Suspended |
|
University of Florida Health Science Center - Gainesville Gainesville, Florida 32610 |
Suspended |
|
Baptist MD Anderson Cancer Center Jacksonville, Florida 32207 |
Suspended |
|
AdventHealth Orlando Orlando, Florida 32803 |
Suspended |
|
Phoebe Putney Memorial Hospital Albany, Georgia 31701 |
Suspended |
|
University Cancer and Blood Center LLC Athens, Georgia 30607 |
Suspended |
|
Augusta Oncology Associates PC-D'Antignac Augusta, Georgia 30901 |
Suspended |
|
Augusta Oncology Associates PC-Wheeler Augusta, Georgia 30909 |
Suspended |
|
Augusta University Medical Center Augusta, Georgia 30912 |
Suspended |
|
CTCA at Southeastern Regional Medical Center Newnan, Georgia 30265 |
Suspended |
|
Saint Alphonsus Cancer Care Center-Boise Boise, Idaho 83706 |
Suspended |
|
Saint Luke's Cancer Institute - Boise Boise, Idaho 83712 |
Suspended |
|
Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho 83605 |
Suspended |
|
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho 83814 |
Suspended |
|
Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho 83619 |
Suspended |
|
Saint Luke's Cancer Institute - Meridian Meridian, Idaho 83642 |
Suspended |
|
Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho 83687 |
Suspended |
|
Saint Luke's Cancer Institute - Nampa Nampa, Idaho 83687 |
Suspended |
|
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho 83854 |
Suspended |
|
Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho 83864 |
Suspended |
|
Saint Luke's Cancer Institute - Twin Falls Twin Falls, Idaho 83301 |
Suspended |
|
Illinois CancerCare-Bloomington Bloomington, Illinois 61704 |
Suspended |
|
Illinois CancerCare-Canton Canton, Illinois 61520 |
Suspended |
|
Illinois CancerCare-Carthage Carthage, Illinois 62321 |
Suspended |
|
Centralia Oncology Clinic Centralia, Illinois 62801 |
Suspended |
|
Rush University Medical Center Chicago, Illinois 60612 |
Suspended |
|
University of Illinois Chicago, Illinois 60612 |
Suspended |
|
Carle at The Riverfront Danville, Illinois 61832 |
Suspended |
|
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois 62526 |
Suspended |
|
Illinois CancerCare-Dixon Dixon, Illinois 61021 |
Suspended |
|
Carle Physician Group-Effingham Effingham, Illinois 62401 |
Suspended |
|
Crossroads Cancer Center Effingham, Illinois 62401 |
Suspended |
|
Illinois CancerCare-Eureka Eureka, Illinois 61530 |
Suspended |
|
NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois 60201 |
Suspended |
|
Illinois CancerCare-Galesburg Galesburg, Illinois 61401 |
Suspended |
|
NorthShore University HealthSystem-Glenbrook Hospital Glenview, Illinois 60026 |
Suspended |
|
NorthShore University HealthSystem-Highland Park Hospital Highland Park, Illinois 60035 |
Suspended |
|
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois 61443 |
Suspended |
|
Illinois CancerCare-Macomb Macomb, Illinois 61455 |
Suspended |
|
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois 61938 |
Suspended |
|
Loyola University Medical Center Maywood, Illinois 60153 |
Suspended |
|
SSM Health Good Samaritan Mount Vernon, Illinois 62864 |
Suspended |
|
Cancer Care Center of O'Fallon O'Fallon, Illinois 62269 |
Suspended |
|
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois 61350 |
Suspended |
|
Illinois CancerCare-Pekin Pekin, Illinois 61554 |
Suspended |
|
Illinois CancerCare-Peoria Peoria, Illinois 61615 |
Suspended |
|
Illinois CancerCare-Peru Peru, Illinois 61354 |
Suspended |
|
Illinois CancerCare-Princeton Princeton, Illinois 61356 |
Suspended |
|
Southern Illinois University School of Medicine Springfield, Illinois 62702 |
Suspended |
|
Springfield Clinic Springfield, Illinois 62702 |
Suspended |
|
Carle Cancer Center Urbana, Illinois 61801 |
Suspended |
|
Illinois CancerCare - Washington Washington, Illinois 61571 |
Suspended |
|
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana 46202 |
Suspended |
|
Community Cancer Center East Indianapolis, Indiana 46219 |
Suspended |
|
Community Cancer Center South Indianapolis, Indiana 46227 |
Suspended |
|
Franciscan Health Indianapolis Indianapolis, Indiana 46237 |
Suspended |
|
Community Cancer Center North Indianapolis, Indiana 46256 |
Suspended |
|
Community Howard Regional Health Kokomo, Indiana 46904 |
Suspended |
|
Franciscan Saint Elizabeth Health - Lafayette East Lafayette, Indiana 47905 |
Suspended |
|
Woodland Cancer Care Center Michigan City, Indiana 46360 |
Suspended |
|
Franciscan Health Mooresville Mooresville, Indiana 46158 |
Suspended |
|
Union Hospital Terre Haute, Indiana 47804 |
Suspended |
|
Mary Greeley Medical Center Ames, Iowa 50010 |
Suspended |
|
McFarland Clinic - Ames Ames, Iowa 50010 |
Suspended |
|
University of Iowa Healthcare Cancer Services Quad Cities Bettendorf, Iowa 52722 |
Suspended |
|
McFarland Clinic - Boone Boone, Iowa 50036 |
Suspended |
|
Mercy Hospital Cedar Rapids, Iowa 52403 |
Suspended |
|
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa 52403 |
Suspended |
|
Mercy Cancer Center-West Lakes Clive, Iowa 50325 |
Suspended |
|
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa 50325 |
Suspended |
|
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa 50309 |
Suspended |
|
Broadlawns Medical Center Des Moines, Iowa 50314 |
Suspended |
|
Mercy Medical Center - Des Moines Des Moines, Iowa 50314 |
Suspended |
|
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa 50314 |
Suspended |
|
McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa 50501 |
Suspended |
|
Trinity Regional Medical Center Fort Dodge, Iowa 50501 |
Suspended |
|
University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa 52242 |
Suspended |
|
McFarland Clinic - Jefferson Jefferson, Iowa 50129 |
Suspended |
|
McFarland Clinic - Marshalltown Marshalltown, Iowa 50158 |
Suspended |
|
Mercy Medical Center-West Lakes West Des Moines, Iowa 50266 |
Suspended |
|
HaysMed Hays, Kansas 67601 |
Suspended |
|
Lawrence Memorial Hospital Lawrence, Kansas 66044 |
Suspended |
|
The University of Kansas Cancer Center - Olathe Olathe, Kansas 66061 |
Suspended |
|
Salina Regional Health Center Salina, Kansas 67401 |
Suspended |
|
University of Kansas Health System Saint Francis Campus Topeka, Kansas 66606 |
Suspended |
|
University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas 66205 |
Suspended |
|
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas 67208 |
Suspended |
|
Cancer Center of Kansas - Wichita Wichita, Kansas 67214 |
Suspended |
|
Flaget Memorial Hospital Bardstown, Kentucky 40004 |
Suspended |
|
Baptist Health Lexington Lexington, Kentucky 40503 |
Suspended |
|
Saint Joseph Hospital East Lexington, Kentucky 40509 |
Suspended |
|
University of Kentucky/Markey Cancer Center Lexington, Kentucky 40536 |
Suspended |
|
Norton Hospital Pavilion and Medical Campus Louisville, Kentucky 40202 |
Suspended |
|
Norton Audubon Hospital and Medical Campus Louisville, Kentucky 40217 |
Suspended |
|
Norton Brownsboro Hospital and Medical Campus Louisville, Kentucky 40241 |
Suspended |
|
Ochsner Medical Center Kenner Kenner, Louisiana 70065 |
Suspended |
|
Ochsner Medical Center Jefferson New Orleans, Louisiana 70121 |
Suspended |
|
Harold Alfond Center for Cancer Care Augusta, Maine 04330 |
Suspended |
|
Eastern Maine Medical Center Bangor, Maine 04401 |
Suspended |
|
MaineHealth Waldo Hospital Belfast, Maine 04915 |
Suspended |
|
MaineHealth Maine Medical Center - Biddeford Biddeford, Maine 04005 |
Suspended |
|
Lafayette Family Cancer Center-EMMC Brewer, Maine 04412 |
Suspended |
|
Penobscot Bay Medical Center Rockport, Maine 04856 |
Suspended |
|
MaineHealth Cancer Care and IV Therapy - Sanford Sanford, Maine 04073 |
Suspended |
|
MaineHealth Cancer Care and IV Therapy - South Portland South Portland, Maine 04106 |
Suspended |
|
Kaiser Permanente-Woodlawn Medical Center Baltimore, Maryland 21244 |
Suspended |
|
University of Maryland Shore Medical Center at Easton Easton, Maryland 21601 |
Suspended |
|
Kaiser Permanente-Gaithersburg Medical Center Gaithersburg, Maryland 20879 |
Suspended |
|
Kaiser Permanente - Largo Medical Center Largo, Maryland 20774 |
Suspended |
|
Kaiser Permanente Lutherville - Timonium Medical Center Lutherville, Maryland 21093 |
Suspended |
|
Dana-Farber Cancer Institute Boston, Massachusetts 02215 |
Suspended |
|
Lowell General Hospital Lowell, Massachusetts 01854 |
Suspended |
|
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan 48106 |
Suspended |
|
McLaren Cancer Institute-Bay City Bay City, Michigan 48706 |
Suspended |
|
McLaren Cancer Institute-Bloomfield Bloomfield, Michigan 48302 |
Suspended |
|
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan 48114 |
Suspended |
|
Trinity Health Medical Center - Brighton Brighton, Michigan 48114 |
Suspended |
|
Henry Ford Cancer Institute-Downriver Brownstown, Michigan 48183 |
Suspended |
|
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan 48188 |
Suspended |
|
Trinity Health Medical Center - Canton Canton, Michigan 48188 |
Suspended |
|
Chelsea Hospital Chelsea, Michigan 48118 |
Suspended |
|
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan 48118 |
Suspended |
|
Hematology Oncology Consultants-Clarkston Clarkston, Michigan 48346 |
Suspended |
|
McLaren Cancer Institute-Clarkston Clarkston, Michigan 48346 |
Suspended |
|
Newland Medical Associates-Clarkston Clarkston, Michigan 48346 |
Suspended |
|
Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan 48038 |
Suspended |
|
Henry Ford Medical Center-Fairlane Dearborn, Michigan 48126 |
Suspended |
|
Wayne State University/Karmanos Cancer Institute Detroit, Michigan 48201 |
Suspended |
|
Henry Ford Hospital Detroit, Michigan 48202 |
Suspended |
|
Weisberg Cancer Treatment Center Farmington Hills, Michigan 48334 |
Suspended |
|
McLaren Cancer Institute-Flint Flint, Michigan 48532 |
Suspended |
|
Singh and Arora Hematology Oncology PC Flint, Michigan 48532 |
Suspended |
|
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan 49503 |
Suspended |
|
Allegiance Health Jackson, Michigan 49201 |
Suspended |
|
West Michigan Cancer Center Kalamazoo, Michigan 49007 |
Suspended |
|
Karmanos Cancer Institute at McLaren Greater Lansing Lansing, Michigan 48910 |
Suspended |
|
University of Michigan Health - Sparrow Lansing Lansing, Michigan 48912 |
Suspended |
|
McLaren Cancer Institute-Lapeer Region Lapeer, Michigan 48446 |
Suspended |
|
Hope Cancer Clinic Livonia, Michigan 48154 |
Suspended |
|
Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan 48154 |
Suspended |
|
McLaren Cancer Institute-Macomb Mount Clemens, Michigan 48043 |
Suspended |
|
McLaren Cancer Institute-Central Michigan Mount Pleasant, Michigan 48858 |
Suspended |
|
Henry Ford Medical Center-Columbus Novi, Michigan 48377 |
Suspended |
|
McLaren Cancer Institute-Northern Michigan Petoskey, Michigan 49770 |
Suspended |
|
Newland Medical Associates-Pontiac Pontiac, Michigan 48341 |
Suspended |
|
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan 48341 |
Suspended |
|
McLaren-Port Huron Port Huron, Michigan 48060 |
Suspended |
|
MyMichigan Medical Center Saginaw Saginaw, Michigan 48601 |
Suspended |
|
Oncology Hematology Associates of Saginaw Valley PC Saginaw, Michigan 48604 |
Suspended |
|
MyMichigan Medical Center Tawas Tawas City, Michigan 48764 |
Suspended |
|
Munson Medical Center Traverse City, Michigan 49684 |
Suspended |
|
Henry Ford West Bloomfield Hospital West Bloomfield, Michigan 48322 |
Suspended |
|
Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan 48661 |
Suspended |
|
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan 48197 |
Suspended |
|
Sanford Joe Lueken Cancer Center Bemidji, Minnesota 56601 |
Suspended |
|
Minnesota Oncology - Burnsville Burnsville, Minnesota 55337 |
Suspended |
|
Essentia Health - Deer River Clinic Deer River, Minnesota 56636 |
Suspended |
|
Essentia Health Cancer Center Duluth, Minnesota 55805 |
Suspended |
|
Essentia Health Hibbing Clinic Hibbing, Minnesota 55746 |
Suspended |
|
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota 55109 |
Suspended |
|
Saint John's Hospital - Healtheast Maplewood, Minnesota 55109 |
Suspended |
|
Hennepin County Medical Center Minneapolis, Minnesota 55415 |
Suspended |
|
Health Partners Inc Minneapolis, Minnesota 55454 |
Suspended |
|
Regions Hospital Saint Paul, Minnesota 55101 |
Suspended |
|
United Hospital Saint Paul, Minnesota 55102 |
Suspended |
|
Essentia Health Sandstone Sandstone, Minnesota 55072 |
Suspended |
|
Essentia Health Virginia Clinic Virginia, Minnesota 55792 |
Suspended |
|
Baptist Cancer Center-Grenada Grenada, Mississippi 38901 |
Suspended |
|
Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi 38652 |
Suspended |
|
Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi 38655 |
Suspended |
|
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi 38671 |
Suspended |
|
Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri 63011 |
Suspended |
|
Saint Francis Medical Center Cape Girardeau, Missouri 63703 |
Suspended |
|
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia, Missouri 65212 |
Suspended |
|
Freeman Health System Joplin, Missouri 64804 |
Suspended |
|
Mercy Hospital Joplin Joplin, Missouri 64804 |
Suspended |
|
University Health Truman Medical Center Kansas City, Missouri 64108 |
Suspended |
|
Saint Louis Cancer and Breast Institute-South City Saint Louis, Missouri 63109 |
Suspended |
|
Mercy Hospital Saint Louis Saint Louis, Missouri 63141 |
Suspended |
|
Community Hospital of Anaconda Anaconda, Montana 59711 |
Suspended |
|
Billings Clinic Cancer Center Billings, Montana 59101 |
Suspended |
|
Bozeman Health Deaconess Hospital Bozeman, Montana 59715 |
Suspended |
|
Benefis Sletten Cancer Institute Great Falls, Montana 59405 |
Suspended |
|
Great Falls Clinic Great Falls, Montana 59405 |
Suspended |
|
Saint Peter's Community Hospital Helena, Montana 59601 |
Suspended |
|
Logan Health Medical Center Kalispell, Montana 59901 |
Suspended |
|
Community Medical Center Missoula, Montana 59804 |
Suspended |
|
Nebraska Methodist Hospital Omaha, Nebraska 68114 |
Suspended |
|
OptumCare Cancer Care at Seven Hills Henderson, Nevada 89052 |
Suspended |
|
OptumCare Cancer Care at Charleston Las Vegas, Nevada 89102 |
Suspended |
|
OptumCare Cancer Care at MountainView Las Vegas, Nevada 89128 |
Suspended |
|
OptumCare Cancer Care at Fort Apache Las Vegas, Nevada 89148 |
Suspended |
|
Renown Regional Medical Center Reno, Nevada 89502 |
Suspended |
|
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon, New Hampshire 03756 |
Suspended |
|
Dartmouth Cancer Center - Manchester Manchester, New Hampshire 03102 |
Suspended |
|
Dartmouth Cancer Center - Nashua Nashua, New Hampshire 03063 |
Suspended |
|
The Cancer Institute of New Jersey Hamilton Hamilton, New Jersey 08690 |
Suspended |
|
Morristown Medical Center Morristown, New Jersey 07960 |
Suspended |
|
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey 08903 |
Suspended |
|
The Valley Hospital - Luckow Pavilion Paramus, New Jersey 07652 |
Suspended |
|
Valley Health System Ridgewood Campus Ridgewood, New Jersey 07450 |
Suspended |
|
Robert Wood Johnson University Hospital Somerset Somerville, New Jersey 08876 |
Suspended |
|
Overlook Hospital Summit, New Jersey 07902 |
Suspended |
|
University of New Mexico Cancer Center Albuquerque, New Mexico 87106 |
Suspended |
|
Presbyterian Kaseman Hospital Albuquerque, New Mexico 87110 |
Suspended |
|
Memorial Medical Center-Las Cruces Las Cruces, New Mexico 88011 |
Suspended |
|
Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho, New Mexico 87124 |
Suspended |
|
Roswell Park Cancer Institute Buffalo, New York 14263 |
Suspended |
|
Arnot Ogden Medical Center/Falck Cancer Center Elmira, New York 14905 |
Suspended |
|
Northwell Health/Center for Advanced Medicine Lake Success, New York 11042 |
Suspended |
|
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York 10016 |
Suspended |
|
University of Rochester Rochester, New York 14642 |
Suspended |
|
Dickstein Cancer Treatment Center White Plains, New York 10601 |
Suspended |
|
UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina 27599 |
Suspended |
|
Southeastern Medical Oncology Center-Clinton Clinton, North Carolina 28328 |
Suspended |
|
Southeastern Medical Oncology Center-Goldsboro Goldsboro, North Carolina 27534 |
Suspended |
|
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina 28791 |
Suspended |
|
Southeastern Medical Oncology Center-Jacksonville Jacksonville, North Carolina 28546 |
Suspended |
|
ECU Health Oncology Kenansville Kenansville, North Carolina 28349 |
Suspended |
|
ECU Health Oncology Kinston Kinston, North Carolina 28501 |
Suspended |
|
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst, North Carolina 28374 |
Suspended |
|
ECU Health Oncology Richlands Richlands, North Carolina 28574 |
Suspended |
|
Wake Forest University Health Sciences Winston-Salem, North Carolina 27157 |
Suspended |
|
Sanford Bismarck Medical Center Bismarck, North Dakota 58501 |
Suspended |
|
Sanford Broadway Medical Center Fargo, North Dakota 58122 |
Suspended |
|
Sanford Roger Maris Cancer Center Fargo, North Dakota 58122 |
Suspended |
|
Altru Cancer Center Grand Forks, North Dakota 58201 |
Suspended |
|
Cleveland Clinic Akron General Akron, Ohio 44307 |
Suspended |
|
Strecker Cancer Center-Belpre Belpre, Ohio 45714 |
Suspended |
|
Dayton Physicians LLC-Miami Valley South Centerville, Ohio 45459 |
Suspended |
|
Miami Valley Hospital South Centerville, Ohio 45459 |
Suspended |
|
Adena Regional Medical Center Chillicothe, Ohio 45601 |
Suspended |
|
University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio 45219 |
Suspended |
|
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland, Ohio 44111 |
Suspended |
|
Ohio State University Comprehensive Cancer Center Columbus, Ohio 43210 |
Suspended |
|
Mount Carmel East Hospital Columbus, Ohio 43213 |
Suspended |
|
Columbus Oncology and Hematology Associates Inc Columbus, Ohio 43214 |
Suspended |
|
Riverside Methodist Hospital Columbus, Ohio 43214 |
Suspended |
|
Grant Medical Center Columbus, Ohio 43215 |
Suspended |
|
The Mark H Zangmeister Center Columbus, Ohio 43219 |
Suspended |
|
Mount Carmel Health Center West Columbus, Ohio 43222 |
Suspended |
|
Doctors Hospital Columbus, Ohio 43228 |
Suspended |
|
Miami Valley Hospital Dayton, Ohio 45409 |
Suspended |
|
Delaware Health Center-Grady Cancer Center Delaware, Ohio 43015 |
Suspended |
|
Grady Memorial Hospital Delaware, Ohio 43015 |
Suspended |
|
Greater Dayton Cancer Center Kettering, Ohio 45409 |
Suspended |
|
Fairfield Medical Center Lancaster, Ohio 43130 |
Suspended |
|
OhioHealth Mansfield Hospital Mansfield, Ohio 44903 |
Suspended |
|
Cleveland Clinic Cancer Center Mansfield Mansfield, Ohio 44906 |
Suspended |
|
Marietta Memorial Hospital Marietta, Ohio 45750 |
Suspended |
|
OhioHealth Marion General Hospital Marion, Ohio 43302 |
Suspended |
|
Hillcrest Hospital Cancer Center Mayfield Heights, Ohio 44124 |
Suspended |
|
Knox Community Hospital Mount Vernon, Ohio 43050 |
Suspended |
|
Licking Memorial Hospital Newark, Ohio 43055 |
Suspended |
|
Southern Ohio Medical Center Portsmouth, Ohio 45662 |
Suspended |
|
North Coast Cancer Care Sandusky, Ohio 44870 |
Suspended |
|
ProMedica Flower Hospital Sylvania, Ohio 43560 |
Suspended |
|
South Pointe Hospital Warrensville Heights, Ohio 44122 |
Suspended |
|
University of Cincinnati Cancer Center-West Chester West Chester, Ohio 45069 |
Suspended |
|
Saint Ann's Hospital Westerville, Ohio 43081 |
Suspended |
|
Genesis Healthcare System Cancer Care Center Zanesville, Ohio 43701 |
Suspended |
|
Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma 73505 |
Suspended |
|
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma 73104 |
Suspended |
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Cancer Treatment Centers of America Tulsa, Oklahoma 74133 |
Suspended |
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Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa, Oklahoma 74146 |
Suspended |
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Saint Charles Health System Bend, Oregon 97701 |
Suspended |
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Clackamas Radiation Oncology Center Clackamas, Oregon 97015 |
Suspended |
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Providence Cancer Institute Clackamas Clinic Clackamas, Oregon 97015 |
Suspended |
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Providence Newberg Medical Center Newberg, Oregon 97132 |
Suspended |
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Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon 97914 |
Suspended |
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Providence Willamette Falls Medical Center Oregon City, Oregon 97045 |
Suspended |
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Providence Portland Medical Center Portland, Oregon 97213 |
Suspended |
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Providence Saint Vincent Medical Center Portland, Oregon 97225 |
Suspended |
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Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania 18103 |
Suspended |
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Saint Luke's Cancer Center - Allentown Allentown, Pennsylvania 18104 |
Suspended |
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Saint Luke's University Hospital-Bethlehem Campus Bethlehem, Pennsylvania 18015 |
Suspended |
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Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania 18017 |
Suspended |
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Saint Luke's Hospital-Anderson Campus Easton, Pennsylvania 18045 |
Suspended |
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Saint Vincent Hospital Erie, Pennsylvania 16544 |
Suspended |
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UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg, Pennsylvania 17109 |
Suspended |
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Jefferson Hospital Jefferson Hills, Pennsylvania 15025 |
Suspended |
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Forbes Hospital Monroeville, Pennsylvania 15146 |
Suspended |
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Allegheny Valley Hospital Natrona Heights, Pennsylvania 15065 |
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Allegheny General Hospital Pittsburgh, Pennsylvania 15212 |
Suspended |
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West Penn Hospital Pittsburgh, Pennsylvania 15224 |
Suspended |
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University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania 15232 |
Suspended |
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Saint Luke's Hospital-Quakertown Campus Quakertown, Pennsylvania 18951 |
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Reading Hospital West Reading, Pennsylvania 19611 |
Suspended |
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Wexford Health and Wellness Pavilion Wexford, Pennsylvania 15090 |
Suspended |
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Asplundh Cancer Pavilion Willow Grove, Pennsylvania 19090 |
Suspended |
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AnMed Health Cancer Center Anderson, South Carolina 29621 |
Suspended |
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Beaufort Memorial Hospital Beaufort, South Carolina 29902 |
Suspended |
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Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina 29316 |
Suspended |
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Prisma Health Cancer Institute - Easley Easley, South Carolina 29640 |
Suspended |
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Saint Francis Hospital Greenville, South Carolina 29601 |
Suspended |
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Prisma Health Cancer Institute - Butternut Greenville, South Carolina 29605 |
Suspended |
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Prisma Health Cancer Institute - Faris Greenville, South Carolina 29605 |
Suspended |
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Saint Francis Cancer Center Greenville, South Carolina 29607 |
Suspended |
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Prisma Health Cancer Institute - Eastside Greenville, South Carolina 29615 |
Suspended |
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Prisma Health Cancer Institute - Greer Greer, South Carolina 29650 |
Suspended |
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Prisma Health Cancer Institute - Seneca Seneca, South Carolina 29672 |
Suspended |
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Spartanburg Medical Center Spartanburg, South Carolina 29303 |
Suspended |
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Avera Cancer Institute-Aberdeen Aberdeen, South Dakota 57401 |
Suspended |
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Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota 57104 |
Suspended |
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Avera Cancer Institute Sioux Falls, South Dakota 57105 |
Suspended |
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Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota 57117-5134 |
Suspended |
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Bristol Regional Medical Center Bristol, Tennessee 37620 |
Suspended |
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Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee 38017 |
Suspended |
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Cookeville Regional Medical Center Cookeville, Tennessee 38501 |
Suspended |
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Wellmont Medical Associates Oncology and Hematology-Johnson City Johnson City, Tennessee 37604 |
Suspended |
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Ballad Health Cancer Care - Kingsport Kingsport, Tennessee 37660 |
Suspended |
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Wellmont Holston Valley Hospital and Medical Center Kingsport, Tennessee 37660 |
Suspended |
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Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee 38120 |
Suspended |
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The Don and Sybil Harrington Cancer Center Amarillo, Texas 79106 |
Suspended |
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Baptist Hospitals of Southeast Texas Cancer Center Beaumont, Texas 77701 |
Suspended |
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MD Anderson in The Woodlands Conroe, Texas 77384 |
Suspended |
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Parkland Memorial Hospital Dallas, Texas 75235 |
Suspended |
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UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas 75390 |
Suspended |
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STCC at DHR Health Institute for Research and Development Edinburg, Texas 78539 |
Suspended |
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Lyndon Baines Johnson General Hospital Houston, Texas 77026-1967 |
Suspended |
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Houston Methodist Hospital Houston, Texas 77030 |
Suspended |
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M D Anderson Cancer Center Houston, Texas 77030 |
Suspended |
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MD Anderson West Houston Houston, Texas 77079 |
Suspended |
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MD Anderson League City League City, Texas 77573 |
Suspended |
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Baptist Regional Cancer Network-Cancer Center of Southeast Texas Port Arthur, Texas 77642 |
Suspended |
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MD Anderson in Sugar Land Sugar Land, Texas 77478 |
Suspended |
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Scott and White Memorial Hospital Temple, Texas 76508 |
Suspended |
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Huntsman Cancer Institute/University of Utah Salt Lake City, Utah 84112 |
Suspended |
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Dartmouth Cancer Center - North Saint Johnsbury, Vermont 05819 |
Suspended |
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Ballad Health Cancer Care - Bristol Bristol, Virginia 24201 |
Suspended |
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Kaiser Permanente-Burke Medical Center Burke, Virginia 22015 |
Suspended |
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Augusta Health Center for Cancer and Blood Disorders Fishersville, Virginia 22939 |
Suspended |
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Centra Alan B Pearson Regional Cancer Center Lynchburg, Virginia 24501 |
Suspended |
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Kaiser Permanente Tysons Corner Medical Center McLean, Virginia 22102 |
Suspended |
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Ballad Health Cancer Care - Norton Norton, Virginia 24273 |
Suspended |
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Virginia Cancer Institute Richmond, Virginia 23229 |
Suspended |
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VCU Massey Cancer Center at Stony Point Richmond, Virginia 23235 |
Suspended |
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Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia 23298 |
Suspended |
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VCU Community Memorial Health Center South Hill, Virginia 23970 |
Suspended |
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Kaiser Permanente-Caton Hill Medical Center Woodbridge, Virginia 22192 |
Suspended |
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Swedish Cancer Institute-Edmonds Edmonds, Washington 98026 |
Suspended |
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Swedish Cancer Institute-Issaquah Issaquah, Washington 98029 |
Suspended |
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Jefferson Healthcare Port Townsend, Washington 98368 |
Suspended |
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Swedish Medical Center-First Hill Seattle, Washington 98122 |
Suspended |
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MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane, Washington 99204 |
Suspended |
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MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane, Washington 99218 |
Suspended |
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West Virginia University Charleston Division Charleston, West Virginia 25304 |
Suspended |
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West Virginia University Healthcare Morgantown, West Virginia 26506 |
Suspended |
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Camden Clark Medical Center Parkersburg, West Virginia 26101 |
Suspended |
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Langlade Hospital and Cancer Center Antigo, Wisconsin 54409 |
Suspended |
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ThedaCare Regional Cancer Center Appleton, Wisconsin 54911 |
Suspended |
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Ascension Saint Elizabeth Hospital Appleton, Wisconsin 54915 |
Suspended |
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Duluth Clinic Ashland Ashland, Wisconsin 54806 |
Suspended |
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Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin 53045 |
Suspended |
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Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin 54701 |
Suspended |
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Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin 53132 |
Suspended |
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Bellin Memorial Hospital Green Bay, Wisconsin 54301 |
Suspended |
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Mercyhealth Hospital and Cancer Center - Janesville Janesville, Wisconsin 53548 |
Suspended |
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University of Wisconsin Carbone Cancer Center - Johnson Creek Johnson Creek, Wisconsin 53038 |
Suspended |
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Gundersen Lutheran Medical Center La Crosse, Wisconsin 54601 |
Suspended |
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison, Wisconsin 53718 |
Suspended |
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University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin 53792 |
Suspended |
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Marshfield Medical Center-Marshfield Marshfield, Wisconsin 54449 |
Suspended |
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Aspirus Medford Hospital Medford, Wisconsin 54451 |
Suspended |
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Marshfield Medical Center - Minocqua Minocqua, Wisconsin 54548 |
Suspended |
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ProHealth D N Greenwald Center Mukwonago, Wisconsin 53149 |
Suspended |
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Cancer Center of Western Wisconsin New Richmond, Wisconsin 54017 |
Suspended |
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ProHealth Oconomowoc Memorial Hospital Oconomowoc, Wisconsin 53066 |
Suspended |
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Ascension Mercy Hospital Oshkosh, Wisconsin 54904 |
Suspended |
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Ascension All Saints Hospital Racine, Wisconsin 53405 |
Suspended |
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Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin 54501 |
Suspended |
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Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin 54868 |
Suspended |
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Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin 54482 |
Suspended |
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ProHealth Waukesha Memorial Hospital Waukesha, Wisconsin 53188 |
Suspended |
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UW Cancer Center at ProHealth Care Waukesha, Wisconsin 53188 |
Suspended |
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Aspirus Regional Cancer Center Wausau, Wisconsin 54401 |
Suspended |
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Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin 53226 |
Suspended |
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Marshfield Medical Center - Weston Weston, Wisconsin 54476 |
Suspended |
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Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin 54494 |
Suspended |
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Cheyenne Regional Medical Center-West Cheyenne, Wyoming 82001 |
Suspended |
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Billings Clinic-Cody Cody, Wyoming 82414 |
Suspended |
Inclusion Criteria
Inclusion Criteria:
* The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
* Age >= 18 years
* Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
* Diagnosis of metastatic adenocarcinoma of colon or rectum without previous chemotherapy or any other systemic therapy for metastatic colorectal cancer except for one cycle of FOLFOX or capecitabine and oxaliplatin (CAPOX), either with or without bevacizumab prior to enrollment. Upon enrollment, the preceding single cycle of FOLFOX or FOLFOX + bevacizumab, if the patient received one, will not count towards patients' assessments per protocol. Cycle 1 day 1 (C1D1) of atezolizumab or C1D1 of mFOLFOX6/bevacizumab + atezolizumab will correspond to the first day the patient received therapy on trial
* Tumor determined to be mismatch-repair deficient (dMMR) by Clinical Laboratory Improvement Act (CLIA)-certified immunohistochemical (IHC) assay with a panel of all four IHC markers, including MLH1, MSH2, PMS2, and MSH6; alternatively, MSI-H diagnosed by polymerase chain reaction (PCR)-based assessment of microsatellite alterations (either Bethesda markers or Pentaplex panel) or by next-generation sequencing (NGS) are eligible
* Documentation by PET/CT scan, CT scan, or MRI that the patient has measurable metastatic disease per RECIST 1.1
* No immediate need for surgical intervention for the primary tumor or palliative diversion/bypass
* Absolute neutrophil count (ANC) must be >= 1500/mm^3 (obtained within 28 days prior randomization)
* Platelet count must be >= 100,000/mm^3 (obtained within 28 days prior randomization)
* Hemoglobin must be >= 8 g/dL (obtained within 28 days prior randomization)
* Total bilirubin must be =< 4 x ULN (upper limit of normal) (obtained within 28 days prior randomization); and
* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be =< 3 x ULN for the lab with the following exception: for patients with documented liver metastases, AST and ALT must be =< 5 x ULN (obtained within 28 days prior randomization)
* Calculated creatinine clearance >= 30 mL/min (obtained within 28 days prior randomization)
* A urine sample tested for proteinuria by either the dipstick method, urinalysis (UA), or a urine protein creatinine (UPC) ratio:
* The dipstick method must indicate 0-1+ protein; if dipstick reading is >= 2+, a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours or a UPC ratio < 1.0
* A urine protein creatinine (UPC) ratio must be < 1.0; if the UPC ratio is >= 1.0 a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours
* Urinalysis must indicate < 30 mg/dl. If urinalysis >= 30 mg/dl, a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours or a UPC ratio < 1.0
* International normalized ratio of prothrombin time (INR) and prothrombin time (PT) must be =< 1.5 x ULN for the lab within 28 days before randomization; patients who are therapeutically treated with an agent such as warfarin may participate if they are on a stable dose and no underlying abnormality in coagulation parameters exists per medical history, regardless of PT/INR results
* Pregnancy test done within 28 days prior randomization must be negative (for women of childbearing potential only); pregnancy testing should be performed according to institutional standards; administration of atezolizumab or mFOLFOX6/bevacizumab/atezolizumab may have an adverse effect on pregnancy and poses a risk to the human fetus, including embryo-lethality; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
* Women of child-bearing potential and men must agree to use adequate contraception methods that result in a failure rate of < 1% per year during the treatment period (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 5 months (150 days) after the last dose of atezolizumab, 6 months after the last dose of bevacizumab, and 6 months after the last dose of mFOLFOX6; a woman is considered to be of childbearing potential if she is not postmenopausal, has not reached a postmenopausal state (>= 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries and/or uterus); examples of contraceptive methods with a failure rate of < 1% per year include: bilateral tubal ligation; male partner sterilization; intrauterine devices; the reliability of sexual abstinence should be evaluated in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient; periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception; men must refrain from donating sperm during this same period
Exclusion Criteria
Exclusion Criteria:
* Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies, fluoropyrimidines, folic acid derivatives or oxaliplatin
* Uncontrolled high blood pressure defined as systolic blood pressure (BP) > 150 mmHg or diastolic BP > 100 mmHg with or without anti-hypertensive medication; patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria
* Documented New York Heart Association (NYHA) class III or IV congestive heart failure
* Serious or non-healing wound, skin ulcer, or bone fracture
* History of inherited bleeding diathesis, gastrointestinal (GI) perforation, significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent arterial thrombosis or symptomatic peripheral ischemia, transient ischemic attack [TIA], cerebrovascular accident [CVA] or arterial thrombotic event), abdominal fistula, intra-abdominal abscess, or active GI bleeding (with cause not addressed) within 6 months prior to randomization, or other medical condition in the opinion of the treating oncologist that makes the risk of cardiovascular or bleeding complications with bevacizumab use unacceptably high
* Other malignancies are excluded unless the patient has completed therapy for the malignancy >= 12 months prior to randomization and is considered disease-free; patients with the following cancers are eligible if diagnosed and treated within the past 12 months: in situ carcinomas or basal cell and squamous cell carcinoma of the skin
* Known DPD (dihydro pyrimidine dehydrogenase) deficiency
* Symptomatic peripheral sensory neuropathy >= grade 2 (Common Terminology Criteria for Adverse Events [CTCAE] version [v] 5.0)
* Prior treatment with oxaliplatin chemotherapy within 6 months prior to randomization
* History of grade 2 hemoptysis (defined as 2.5 mL of bright red blood per episode) within 1 month prior to screening
* Prior treatment with anti-PD-1, or anti-PD-L1 therapeutic antibody or pathway-targeting agents; patients who have received prior treatment with anti-CTLA-4 may be enrolled provided the following requirements are met:
* Minimum of 12 weeks from the first dose of anti-CTLA-4 and > 6 weeks from the last dose to randomization
* No history of severe immune-related adverse effects (CTCAE grade 3 and 4) from anti-CTLA-4
* Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF] agents) within 14 days prior to randomization; however,
* Patients who have received acute, low dose, systemic immunosuppressant medications (e.g., a one-time dose of dexamethasone for nausea; or chronic daily treatment with corticosteroids with a dose of =< 10 mg/day methylprednisolone equivalent) may be enrolled
* The use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) for patients with orthostatic hypotension or adrenocortical insufficiency is allowed
* Known clinically significant liver disease, including active viral, alcoholic, or other hepatitis; cirrhosis; fatty liver; and inherited liver disease; however,
* Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen [HbsAg] test and a positive anti-HBc [antibody to hepatitis B core antigen] antibody test) are eligible if polymerase chain reaction (PCR) for hepatits B virus (HBV) ribonucleic acid (RNA) is negative per local guidelines
* Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV RNA per local guidelines
* History or risk of autoimmune disease, including, but not limited to, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis; however,
* Patients with a history of autoimmune hypothyroidism on a stable dose of thyroid replacement hormone may be eligible
* Patients with controlled type 1 diabetes mellitus on a stable insulin regimen may be eligible
* Patients with eczema, psoriasis, lichen simplex chronicus or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis would be excluded) are permitted provided that they meet the following conditions:
* Patients with psoriasis must have a baseline ophthalmologic exam to rule out ocular manifestations
* Rash must cover less than 10% of body surface area (BSA)
* Disease is well controlled at baseline and only requiring low potency topical steroids (e.g., hydrocortisone 2.5%, hydrocortisone butyrate 0.1%, fluocinolone 0.01%, desonide 0.05%, alclometasone dipropionate 0.05%)
* No acute exacerbations of underlying condition within the last 12 months (not requiring psoralen plus ultraviolet A radiation [PUVA], methotrexate, retinoids, biologic agents, oral calcineurin inhibitors; high potency or oral steroids)
* History of idiopathic pulmonary fibrosis, organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or active or recently active (within 90 days of randomization) pneumonitis (including drug induced) that required systemic immunosuppressive therapy (i.e. corticosteroids, etc.). History of radiation pneumonitis in the radiation field (fibrosis) is permitted
* History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
* Patients with known active tuberculosis (TB) are excluded
* Severe infections within 28 days prior to randomization, including but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia
* Signs or symptoms of infection within 14 days prior to randomization
* Received oral or intravenous (IV) antibiotics within 14 days prior to randomization; patients receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are eligible
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to randomization or anticipation of need for a major surgical procedure during the course of the study
* The administration of a live, attenuated vaccine within 28 days prior to randomization
* Pregnant women are excluded from this study because atezolizumab is an agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with atezolizumab, breastfeeding should be discontinued if the mother is treated with atezolizumab; these potential risks may also apply to other agents used in this study; (Note: pregnancy testing should be performed within 28 days prior to randomization according to institutional standards for women of childbearing potential)
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
* Patients with prior allogeneic bone marrow transplantation or prior solid organ transplantation
