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Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Program Status

Recruiting

Phase

Phase 2

Prior Immunotherapy Allowed

CRC-directed Trial

Drugs

Alectinib, Atezolizumab, Belvarafenib, Entrectinib, Idasanutlin, Inavolisib, Ipatasertib, Pralsetinib, Trastuzumab emtansine

Tags

MSI-H/ MMRd, MSS/ MMRp

Location	Location Status
United States
Southern Cancer Center Daphne, Alabama 36526	Withdrawn
Western Regional Medical Center at Cancer Treatment Centers of America Goodyear, Arizona 85338	Completed
City of Hope National Medical Center Duarte, California 91010	Withdrawn
Kaiser Permanente Los Angeles Los Angeles, California 90027	Active, not recruiting
USC Norris Cancer Center Los Angeles, California 90033	Completed
Hoag Memorial Hospital Newport Beach, California 92658	Completed
UC Davis Comprehensive Cancer Center Sacramento, California 95817	Completed
University of California at San Francisco San Francisco, California 94158	Withdrawn
Sarcoma Oncology Center Santa Monica, California 90403	Withdrawn
Children's Hospital Colorado Aurora, Colorado 80045	Withdrawn
Christiana Care Health Srvcs Newark, Delaware 19713	Withdrawn
University of Florida Gainesville, Florida 32610	Withdrawn
Miami Cancer Institute of Baptist Health, Inc. Miami, Florida 33176	Active, not recruiting
Ocala Oncology Center Ocala, Florida 34474	Withdrawn
University Cancer & Blood Center, LLC Athens, Georgia 30607	Completed
St. Alphonsus Boise, Idaho 83706	Completed
Midwestern Regional Med Center Zion, Illinois 60099	Completed
Horizon Oncology Research, Inc. Lafayette, Indiana 47905	Completed
New England Cancer Specialists Scarborough, Maine 04074	Withdrawn
Maryland Hematology & Oncology. P.A. Silver Spring, Maryland 20904	Recruiting
St. Joseph Mercy Hospital Ann Arbor, Michigan 48106	Withdrawn
Henry Ford Health System Detroit, Michigan 48202	Recruiting
University of Minnesota Minneapolis, Minnesota 55455	Withdrawn
Metro-Minnesota Community Oncology Research Consortium Saint Louis Park, Minnesota 55416	Recruiting
Washington University Saint Louis, Missouri 63110	Withdrawn
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana Billings, Montana 59102	Completed
Nebraska Methodist Hospital Omaha, Nebraska 68114	Withdrawn
Comprehensive Cancer Centers of Nevada - Eastern Avenue Las Vegas, Nevada 89169	Withdrawn
Dartmouth Hitchcock Medical Center Lebanon, New Hampshire 03756	Active, not recruiting
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey 08901	Completed
University of New Mexico Albuquerque, New Mexico 87131	Completed
Montefiore Einstein Center for Cancer Care Bronx, New York 10461	Recruiting
Eastchester Center for Cancer Care Bronx, New York 10469	Withdrawn
National Translational Research Group New York, New York 10028	Withdrawn
Icahn School of Medicine at Mount Sinai New York, New York 10029	Active, not recruiting
Memorial Sloan Kettering Cancer Center New York, New York 11101	Completed
New York Cancer and Blood Specialists - Setauket Medical Oncology Port Jefferson Station, New York 11776	Withdrawn
Barrett Cancer Center Cincinnati, Ohio 45219	Completed
Oncology Hematology Care Inc Cincinnati, Ohio 45242	Completed
Providence Portland Medical Center Portland, Oregon 97213	Withdrawn
Consultants in Medical Oncology and Hematology Broomall, Pennsylvania 19008	Recruiting
Alliance Cancer Specialists Horsham, Pennsylvania 19044	Recruiting
Virginia Cancer Specialists - Leesburg Leesburg, Pennsylvania 20176	Recruiting
Cancer Treatment Centers of America Philadelphia, Pennsylvania 19124	Completed
The Children's Hospital of Philadelphia Philadelphia, Pennsylvania 19401	Withdrawn
PRISMA Health - Greenville Greenville, South Carolina 29605	Withdrawn
The West Clinic Germantown, Tennessee 38138	Recruiting
St. Jude Children'S Research Hospital Memphis, Tennessee 38105	Active, not recruiting
Texas Oncology - Central South Austin, Texas 78731	Recruiting
Mary Crowley Medical Research Center Dallas, Texas 75230	Recruiting
Texas Oncology - Baylor Charles A. Sammons Cancer Center Dallas, Texas 75246	Terminated
Cook Childrens Medical Center Fort Worth, Texas 76104	Withdrawn
The University of Texas MD Anderson Cancer Center Houston, Texas 77030-4009	Recruiting
Texas Oncology- Northeast Texas Tyler, Texas 75702	Recruiting
Northwest Medical Specialties, PLLC Tacoma, Washington 98405	Recruiting
Froedtert and The Medical College of Wisconsin Milwaukee, Wisconsin 53226	Recruiting
Australia
Kinghorn Cancer Centre Darlinghurst, New South Wales 2010	Recruiting
Sydney Children's Hospital Randwick, New South Wales 2031	Withdrawn
Royal Darwin Hospital Tiwi, Northern Territory 0810	Withdrawn
Princess Alexandra Hospital Woolloongabba, Queensland 4102	Recruiting
Peter MacCallum Cancer Centre Melbourne, Victoria 3000	Active, not recruiting
Royal Children's Hospital Parkville, Victoria 3052	Recruiting
Belgium
Cliniques Universitaires St-Luc Bruxelles 1200	Recruiting
GHdC Site Les Viviers Charleroi 6060	Recruiting
UZ Antwerpen Edegem 2650	Completed
UZ Gent Gent 9000	Recruiting
UZ Leuven Gasthuisberg Leuven 3000	Active, not recruiting
Brazil
Hospital Moinhos de Vento Porto Alegre, Rio Grande Do Sul 90035-001	Withdrawn
Hospital Sírio-Libanês Sao Paulo, São Paulo 01308-050	Withdrawn
Hospital Sírio-Libanês Sao Paulo, São Paulo 01308-050	Recruiting
Hospital A. C. Camargo Sao Paulo, São Paulo 01509-010	Active, not recruiting
Clínica Onco Star - Rede D'Or Sao Paulo, São Paulo 04543-000	Recruiting
Canada
BC Cancer ? Vancouver Vancouver, British Columbia V5Z 1J3	Recruiting
London Health Sciences Centre · Victoria Hospital London, Ontario N6A 5W9	Recruiting
The Ottawa Hospital - General Campus Ottawa, Ontario K1H 8L6	Recruiting
The Hospital for Sick Children Toronto, Ontario M5G 1H3	Recruiting
Princess Margaret Cancer Center Toronto, Ontario M5G 2M9	Withdrawn
McGill University Health Center Montreal, Quebec H4A 3J1	Withdrawn
China
Beijing Cancer Hospital Beijing 100142	Recruiting
Beijing Children's Hospital, Capital Medical University Beijing	Recruiting
The First Hospital of Jilin University Changchun City 130021	Withdrawn
Jilin Cancer Hospital Changchun 132013	Withdrawn
West China Hospital - Sichuan University Chengdu City 610047	Recruiting
Shanghai East Hospital Shanghai City 200126	Withdrawn
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092	Recruiting
Zhongshan Hospital Fudan Unvierstiy Shanghai	Recruiting
Tianjin Cancer Hospital Tianjin 300060	Recruiting
First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710061	Recruiting
Denmark
Aarhus Universitetshospital Aarhus N 8200	Withdrawn
Rigshospitalet København Ø 2100	Active, not recruiting
France
Institut Bergonie Bordeaux 33076	Active, not recruiting
Centre Oscar Lambret Lille 59020	Active, not recruiting
Centre Leon Berard Lyon 69373	Active, not recruiting
Hopital de la Timone Marseille 13005	Active, not recruiting
Institut Universitaire du Cancer de Toulouse-Oncopole Toulouse 31059	Active, not recruiting
Institut de Cancerologie Gustave-Roussy (IGR) Villejuif 94805	Active, not recruiting
Germany
Uniklinik Essen Essen 45122	Completed
Georg-August-Uniklinik Göttingen 37075	Completed
Universitätsklinikum Hamburg-Eppendorf Onkologisches Zentrum Medizinische Klinik II Hamburg 20246	Recruiting
Medizinische Hochschule Zentrum Innere Medizin Abt.Gastroenterologie, Endokrinologie und Hepatologie Hannover 30625	Recruiting
SLK-Kliniken Heilbronn GmbH;Klinik für Innere Medizin III Heilbronn 74078	Active, not recruiting
Praxis für Hämatologie, Onkologie und Palliativmedizin Mönchengladbach 41066	Completed
Klinikum der Universität München, Campus Großhadern München 81377	Withdrawn
Universtitätsklinikum Ulm Ulm 89081	Withdrawn
Uniklinikum, Comprehensive Cancer Center Mainfranken Würzburg 97078	Withdrawn
Hong Kong
Hong Kong Children's Hospital Hong Kong	Recruiting
Prince of Wales Hospital Shatin	Recruiting
Israel
Rambam Health Care Campus Haifa 3109601	Recruiting
Hadassah University Hospital - Ein Kerem Jerusalem 9112001	Recruiting
Rabin MC Petach Tikva 4941492	Recruiting
Sheba Medical Center Ramat Gan 5262100	Active, not recruiting
Sourasky / Ichilov Hospital Tel Aviv 6423906	Recruiting
Italy
Istituto Nazionale Tumori Fondazione G. Pascale Napoli, Campania 80131	Withdrawn
Ospedale Pediatrico Bambino Gesù - IRCCS Roma, Lazio 00165	Recruiting
Policlinico Universitario Agostino Gemelli IRCCS Roma, Lazio 00168	Active, not recruiting
Asst Degli Spedali Civili Di Brescia Brescia, Lombardia 25100	Active, not recruiting
Irccs Istituto Nazionale Dei Tumori (Int) Milano, Lombardia 20133	Recruiting
Istituto Nazionale Tumori di Milano Milano, Lombardia 20133	Recruiting
Dipartimento di Scienze Pediatriche Adolescenza Torino, Piemonte 10126	Recruiting
Azienda Ospedaliera Meyer Firenze, Toscana 50139	Withdrawn
Azienda Ospedaliera Universitaria Senese, U.O.C. Immunoterapia Oncologica Siena, Toscana 53100	Recruiting
Japan
National Cancer Center Hospital East Chiba 277-8577	Withdrawn
Kindai University Hospital Osaka 589-8511	Completed
National Cancer Center Hospital Tokyo 104-0045	Recruiting
Korea, Republic of
Seoul National University Bundang Hospital Gyeonggi-do 13620	Active, not recruiting
Seoul National University Hospital- Adult Site Seoul 03080	Recruiting
Seoul National University Hospital- Pediatric Site Seoul 03080	Recruiting
Severance Hospital, Yonsei University Health System Seoul 03722	Recruiting
Asan Medical Center Seoul 05505	Active, not recruiting
Samsung Medical Center- Adult Site Seoul 06351	Active, not recruiting
Samsung Medical Center- Pediatric Site Seoul 06351	Recruiting
New Zealand
Auckland City Hospital, Cancer and Blood Research Auckland 1023	Recruiting
Poland
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii Gda?sk 80-214	Active, not recruiting
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad Warszawa 02-781	Recruiting
Portugal
IPO do Porto Porto 4200-072	Active, not recruiting
Puerto Rico
PanOncology Trials San Juan 00935	Recruiting
Singapore
National University Hospital Singapore 119228	Recruiting
National Cancer Centre Singapore 168583	Active, not recruiting
South Africa
Medical Oncology Centre of Rosebank Johannesburg 2196	Withdrawn
Spain
Hospital Sant Joan De Deu Esplugues De Llobregas, Barcelona 08950	Recruiting
Vall d'Hebron Institute of Oncology (VHIO), Barcelona Barcelona 08035	Recruiting
Vall d?Hebron Institute of Oncology (VHIO), Barcelona Barcelona 08035	Recruiting
Hospital Infantil Universitario Nino Jesus Madrid 28009	Recruiting
Clinica Universidad de Navarra Madrid Madrid 28027	Recruiting
START Madrid-FJD, Hospital Fundacion Jimenez Diaz Madrid 28040	Recruiting
Hospital Universitario 12 de Octubre Madrid 28041	Recruiting
Hospital Universitario La Paz Madrid 28046	Recruiting
START Madrid. Centro Integral Oncologico Clara Campal Madrid 28050	Recruiting
Hospital Universitario la Fe Valencia 46026	Recruiting
Switzerland
Universitätsspital Basel (USB) Basel 4031	Withdrawn
Ospedale Regionale di Bellinzona Medizin Onkologie Bellinzona 6500	Withdrawn
Inselspital, Klinik und Poliklinik für Medizinische Onkologie Bern 3010	Active, not recruiting
Unversitätsspital Zürich Zürich 8091	Withdrawn
Taiwan
Taichung Veterans General Hospital Taichung 40705	Withdrawn
National Cheng Kung University Hospital Tainan 00704	Recruiting
Taipei Veterans General Hospital Taipei City 112201	Recruiting
Chang Gung Memorial Hospital-Linkou Taoyuan County 333	Recruiting
National Taiwan University Hospital Zhongzheng Dist. 10048	Active, not recruiting
United Kingdom
Beatson West of Scotland Cancer Centre Glasgow G12 0YN	Completed
University College London Hospital London NW1 - 2PG	Completed
Guys and St Thomas NHS Foundation Trust, Guys Hospital London SE1 9RT	Withdrawn
Royal Manchester Children?s Hospital Manchester M13 9WL	Withdrawn
The Christie NHS Foundation Trust Manchester M20 4BX	Withdrawn

Contacts

Reference Study ID Number: BO41932 https://forpatients.roche.com/
CONTACT
888-662-6728 (U.S. and Canada) Global-Roche-Genentech-Trials@gene.com

Inclusion Criteria

Inclusion Criteria:

* Histologically or cytologically confirmed diagnosis of advanced and unresectable or metastatic solid malignancy
* Measurable disease as defined by Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST v1.1), Response Assessment in Neuro-Oncology (RANO) criteria, or International Neuroblastoma Response Criteria (INRC)
* Performance status as follows: Participantss aged >= 18 years: Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2; Participantss aged 16 to < 18 years: Karnofsky score >= 50%; Participants aged < 16 years: Lansky score >= 50%
* For participants aged >= 18 and = 8 weeks
* Ability to comply with the study protocol, in the investigator's judgment
* For female participants of childbearing potential: Negative serum pregnancy test <= 14 days prior to initiating study treatment; agreement to remain abstinent or use single or combined contraception methods that result in a failure rate of < 1% per year for the period defined in the cohort-specific inclusion criteria; and agreement to refrain from donating eggs during the same period
* For male participants: Willingness to remain abstinent or use acceptable methods of contraception as defined in the cohort-specific inclusion criteria
* In addition to the general inclusion criteria above, participants must meet all of the cohort-specific inclusion criteria for the respective cohort

Exclusion Criteria

Exclusion Criteria:

* Current participation or enrollment in another therapeutic clinical trial
* Any anticancer treatment within 2 weeks or 5 half-lives prior to start of study treatment
* Whole brain radiotherapy within 14 days prior to start of study treatment
* Stereotactic radiosurgery within 7 days prior to start of study treatment
* Pregnant or breastfeeding, or intending to become pregnant during the study
* History of or concurrent serious medical condition or abnormality in clinical laboratory tests that, in the investigator's judgment, precludes the participant's safe participation in and completion of the study or confounds the ability to interpret data from the study
* Incomplete recovery from any surgery prior to the start of study treatment that would interfere with the determination of safety or efficacy of study treatment
* Significant cardiovascular disease, such as New York Heart Association cardiac disease (Class II or higher), myocardial infarction, or cerebrovascular accident within 3 months prior to enrollment, unstable arrhythmias, or unstable angina
* History of another active cancer within 5 years prior to screening that may interfere with the determination of safety or efficacy of study treatment with respect to the qualifying solid tumor malignancy
* In addition to the general exclusion criteria above, in order to be enrolled in a treatment cohort of the study, participants must not meet any of the cohort-specific exclusion criteria

NCT ID

NCT04589845

Date Trial Added

2020-10-19

Updated Date

2025-02-17