Exercise Trials
Exercise Trials
Exercise Trials
Research shows that a healthy lifestyle can lower your risk of getting colorectal cancer, decrease the risk of it coming back (recurrence), and even help prepare you for surgery. Even though we know the benefits of exercise, one thing that’s not talked about enough is exercise research – and how the community can contribute to improving our understanding of exercise, and prevention and disease management.
Highlights:
- There are several clinical trials investigating the benefits of physical activity.
- Amico study is looking at the effects of exercise on clinical outcome, the optimal exercise prescription, and the mechanisms that can help explain how exercise may boost benefit from chemotherapy treatment.
- The Effect on Exercise on Cancer trial is exploring how aerobic exercise can reduce the level of ctDNA found in the blood.
- ABCSG C08 is looking at the efficacy of endurance exercise following adjuvant chemotherapy.
- POSTEx is looking at anaerobic threshold change and completion of the exercise program, changes in quality of life, inflammatory markers, and changes in muscle composition.
- In the Tools to be Fit trials, exercise is one of the four interventions proposed to prevent recurrence in stage II, stage III, and stage IV CRC patients who don’t present evidence of disease after definitive treatment but present detectable circulating tumor DNA (ctDNA) mutation that matches mutations found in tumor tissue.
Más recursos de Fight CRC
AMICO
Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome (AMICO)
Radboud University Medical Center/Netherlands Cancer Institute
The investigators hypothesize that exercise prevents chemotherapy dose modifications by reducing toxicity and enhancing psychological strength. This study is a three-armed trial for 228 participants comparing resistance exercise, aerobic interval exercise, and usual care in patients with metastatic CRC to select the optimal exercise prescription for preventing chemotherapy dose modifications. This study hopes to collect evidence for the effects of exercise on i) clinical outcome, ii) the optimal exercise prescription, and iii) the mechanisms that can help explain how exercise may boost benefit from chemotherapy treatment.
Effect of Exercise
Researching the Effect of Exercise on Cancer
MSK several locations
The purpose of this study for 70 participants is to explore how aerobic exercise (exercise that stimulates and strengthens the heart and lungs, and improves the body’s use of oxygen) can reduce the level of ctDNA found in the blood. During the study, the highest level of exercise that is practical, is safe, and has positive effects on the body that may prevent the return of cancer (including a decrease in ctDNA levels) will be found.
Each level of exercise tested will be a certain number of minutes each week. Once the best level of exercise is found, it will be tested further in a new group of participants. All participants in this study have been previously treated for breast, prostate, or CRC.
ABCSG C08
ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer (ABCSG C08)
Austrian Breast and Colorectal Cancer Study Group
ABCSG C08 is a randomized, two-arm, multicenter trial of 788 participants to investigate the efficacy of endurance exercise following adjuvant chemotherapy in patients with CRC in participants with locally advanced CRC after adjuvant chemotherapy. The primary endpoint is disease-free survival. Secondary endpoints include relapse-free survival, overall survival, various physical activity endpoints, patient-reported outcome endpoints, etc.
POSTEx
Supervised Exercise for Post-surgery Colorectal Cancer Patients (POSTEx)
UK
Participants (n=34) will undergo baseline screening before surgery and will be randomized to either normal postoperative care or a 12-week supervised exercise program composed of both an aerobic and resistance component. They will be assessed prior to surgery, which will include cardiopulmonary exercise testing to check aerobic exercise response. The assessment days will also include: muscle ultrasound (vastus lateralis) to ascertain muscle structure, blood tests, functional composite scores, and quality-of-life (qol) questionnaires. The primary outcome is anaerobic threshold change and secondary outcomes look at completion of the exercise program, changes in qol, inflammatory markers, and changes in muscle composition.
Tools To Be Fit
Improving Nutrition and Physical Activity for Colorectal Cancer Survivors (Tools To Be Fit) (TTBF)
This trial is for patients who had stage I, stage II, or stage III colon or rectal cancer and have completed their treatments, and for one support person who will participate in the study, along with the patients.
Here, physical activity is just one of the areas of intervention. The other one is nutrition.
Studies indicate that people with CRC whose nutrition and physical activity habits are consistent with the American Cancer Society’s Nutrition and Physical Activity Guidelines may have longer disease-free survival. All patients receive a personal report about their current nutrition and physical activity; after that, they are assigned to diverse combinations of four different intervention components, during one year, to help them adopt recommended health behaviors:
- Patients receive text messages
- Patients use digital health tool kit
- Patients receive health coaching sessions
- Support persons receive four coaching sessions
DAILY: Vitamin D, Aspirin, ExercIse, Low Saturated Fat Foods StudY in Colorectal Cancer Patients With Minimal Residual Disease
In this clinical trial at M.D. Anderson, exercise is one of the four interventions proposed to prevent recurrence in stage II, stage III, and stage IV CRC patients who don’t present evidence of disease after definitive treatment but present detectable circulating tumor DNA (ctDNA) mutation that matches mutations found in tumor tissue.
The trial combines aspirin, vitamin D, and counseling to follow a plant-based diet (low saturated fat foods), and to increase recreational physical activity, during three months. After that, researchers will evaluate the status of the ctDNA, to determine if the interventions have affected the likelihood of advanced CRC coming back (recurring).
Manténgase informado
Una vez al mes, Maia Walker y Manju George dedican tiempo a desgranar importantes ensayos de investigación, consejos y sugerencias para nuestra comunidad. Asegúrese de suscribirse a Fight CRC y unirse a la comunidad en línea de COLONTOWN para seguir recibiendo las actualizaciones más relevantes del mundo de la CRC.
You can also follow Maia (@sassycell) and Manju (@manjuggm) to stay updated on research and trials and visit ClinicalTrials.gov for more information on trials.
Research shows that a healthy lifestyle can lower your risk of getting colorectal cancer, decrease the risk of it coming back (recurrence), and even help prepare you for surgery. Even though we know the benefits of exercise, one thing that’s not talked about enough is exercise research – and how the community can contribute to improving our understanding of exercise, and prevention and disease management.
Highlights:
- There are several clinical trials investigating the benefits of physical activity.
- Amico study is looking at the effects of exercise on clinical outcome, the optimal exercise prescription, and the mechanisms that can help explain how exercise may boost benefit from chemotherapy treatment.
- The Effect on Exercise on Cancer trial is exploring how aerobic exercise can reduce the level of ctDNA found in the blood.
- ABCSG C08 is looking at the efficacy of endurance exercise following adjuvant chemotherapy.
- POSTEx is looking at anaerobic threshold change and completion of the exercise program, changes in quality of life, inflammatory markers, and changes in muscle composition.
- In the Tools to be Fit trials, exercise is one of the four interventions proposed to prevent recurrence in stage II, stage III, and stage IV CRC patients who don’t present evidence of disease after definitive treatment but present detectable circulating tumor DNA (ctDNA) mutation that matches mutations found in tumor tissue.
Más recursos de Fight CRC
AMICO
Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome (AMICO)
Radboud University Medical Center/Netherlands Cancer Institute
The investigators hypothesize that exercise prevents chemotherapy dose modifications by reducing toxicity and enhancing psychological strength. This study is a three-armed trial for 228 participants comparing resistance exercise, aerobic interval exercise, and usual care in patients with metastatic CRC to select the optimal exercise prescription for preventing chemotherapy dose modifications. This study hopes to collect evidence for the effects of exercise on i) clinical outcome, ii) the optimal exercise prescription, and iii) the mechanisms that can help explain how exercise may boost benefit from chemotherapy treatment.
Effect of Exercise
Researching the Effect of Exercise on Cancer
MSK several locations
The purpose of this study for 70 participants is to explore how aerobic exercise (exercise that stimulates and strengthens the heart and lungs, and improves the body’s use of oxygen) can reduce the level of ctDNA found in the blood. During the study, the highest level of exercise that is practical, is safe, and has positive effects on the body that may prevent the return of cancer (including a decrease in ctDNA levels) will be found.
Each level of exercise tested will be a certain number of minutes each week. Once the best level of exercise is found, it will be tested further in a new group of participants. All participants in this study have been previously treated for breast, prostate, or CRC.
ABCSG C08
ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer (ABCSG C08)
Austrian Breast and Colorectal Cancer Study Group
ABCSG C08 is a randomized, two-arm, multicenter trial of 788 participants to investigate the efficacy of endurance exercise following adjuvant chemotherapy in patients with CRC in participants with locally advanced CRC after adjuvant chemotherapy. The primary endpoint is disease-free survival. Secondary endpoints include relapse-free survival, overall survival, various physical activity endpoints, patient-reported outcome endpoints, etc.
POSTEx
Supervised Exercise for Post-surgery Colorectal Cancer Patients (POSTEx)
UK
Participants (n=34) will undergo baseline screening before surgery and will be randomized to either normal postoperative care or a 12-week supervised exercise program composed of both an aerobic and resistance component. They will be assessed prior to surgery, which will include cardiopulmonary exercise testing to check aerobic exercise response. The assessment days will also include: muscle ultrasound (vastus lateralis) to ascertain muscle structure, blood tests, functional composite scores, and quality-of-life (qol) questionnaires. The primary outcome is anaerobic threshold change and secondary outcomes look at completion of the exercise program, changes in qol, inflammatory markers, and changes in muscle composition.
Tools To Be Fit
Improving Nutrition and Physical Activity for Colorectal Cancer Survivors (Tools To Be Fit) (TTBF)
This trial is for patients who had stage I, stage II, or stage III colon or rectal cancer and have completed their treatments, and for one support person who will participate in the study, along with the patients.
Here, physical activity is just one of the areas of intervention. The other one is nutrition.
Studies indicate that people with CRC whose nutrition and physical activity habits are consistent with the American Cancer Society’s Nutrition and Physical Activity Guidelines may have longer disease-free survival. All patients receive a personal report about their current nutrition and physical activity; after that, they are assigned to diverse combinations of four different intervention components, during one year, to help them adopt recommended health behaviors:
- Patients receive text messages
- Patients use digital health tool kit
- Patients receive health coaching sessions
- Support persons receive four coaching sessions
DAILY: Vitamin D, Aspirin, ExercIse, Low Saturated Fat Foods StudY in Colorectal Cancer Patients With Minimal Residual Disease
In this clinical trial at M.D. Anderson, exercise is one of the four interventions proposed to prevent recurrence in stage II, stage III, and stage IV CRC patients who don’t present evidence of disease after definitive treatment but present detectable circulating tumor DNA (ctDNA) mutation that matches mutations found in tumor tissue.
The trial combines aspirin, vitamin D, and counseling to follow a plant-based diet (low saturated fat foods), and to increase recreational physical activity, during three months. After that, researchers will evaluate the status of the ctDNA, to determine if the interventions have affected the likelihood of advanced CRC coming back (recurring).
Manténgase informado
Una vez al mes, Maia Walker y Manju George dedican tiempo a desgranar importantes ensayos de investigación, consejos y sugerencias para nuestra comunidad. Asegúrese de suscribirse a Fight CRC y unirse a la comunidad en línea de COLONTOWN para seguir recibiendo las actualizaciones más relevantes del mundo de la CRC.
You can also follow Maia (@sassycell) and Manju (@manjuggm) to stay updated on research and trials and visit ClinicalTrials.gov for more information on trials.
