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Clinical trial by NCI SB (Surgery Branch); principal investigator is Dr. Steven Rosenberg. The study uses adoptive cell transfer (ACT) therapy that involves isolating T-cell receptors (TCR) that recognize mutated cancer neoantigens, and admits patients with metastatic colorectal cancer with a KRAS G12V or G12D mutation.

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Criterios de inclusión

* CRITERIOS DE INCLUSIÓN:
* Participants with an appropriate HLA match for available Surgery Branch KRAS TCRs with evaluable metastatic solid cancer (e.g., gastrointestinal, genitourinary, breast, ovarian, non-small cell lung cancer (NSCLC) and other solid cancers) with known KRAS G12V or G12D mutation.
* Confirmation of diagnosis of cancer by the NCI Laboratory of Pathology.
* Refractory to standard systemic therapy. Specifically:

* Participants with metastatic colorectal cancer must have received oxaliplatin and/or irinotecan.
* Participants with breast and ovarian cancer must have received at least two systemic treatments.
* Participants with NSCLC must have received at least one platinum-based chemotherapy regimen and at least one FDA-approved targeted treatment (when appropriate).
* Participants with other solid tumors must have received at least one prior line of systemic treatment or have declined standard treatment.
* Participants with three (3) or fewer brain metastases that are < 1 cm in diameter each and asymptomatic are eligible. Lesions that have been treated with stereotactic radiosurgery must be clinically stable for one month after treatment for the participant to be eligible. Participants with surgically resected brain metastases are eligible. * Age >= 18 years and 1000/mm^3 without growth factor support
* WBC >= 2500/mm^3
* Platelet count (Bullet) 80,000/mm3
* Hemoglobina > 8,0 g/dL. Los sujetos pueden ser transfundidos para alcanzar este límite.
* Chemistry:
* Serum ALT/AST <= 5.0 x ULN
* Serum creatinine <= 1.6 mg/dL
* Total bilirubin <= 2.0 mg/dL, except in participants with Gilbert s Syndrome, who must have a total bilirubin < 3.0 mg/dL.
* Participants must have completed any prior systemic therapy at the time of enrollment.

NOTE: Participants may have undergone minor surgical procedures or limited field radiotherapy within the four weeks prior to enrollment, as long as related major organ toxicities have recovered to grade 1 or less.

* For participants with NSCLC or lung metastases, more than two weeks must have elapsed since any prior palliation for major bronchial occlusion or bleeding at the time the patient receives the preparative regimen, and patient s toxicities must have recovered to a grade 1 or less.
* Ability of subject to understand and the willingness to sign a written informed consent document.
* Willing to sign a durable power of attorney.
* Participants must be co-enrolled on protocol 03-C-0277.

Criterios de exclusión

CRITERIOS DE EXCLUSIÓN:

* Participants who are pregnant or nursing because of the potentially dangerous effects of the treatment on the fetus or infant.
* Any form of secondary immunosuppression.
* Active systemic infections requiring anti-infective treatment, coagulation disorders, or any other active or uncompensated major medical illnesses.
* For participants with NSCLC or lung metastases, any major bronchial occlusion or bleeding not amenable to palliation.
* Any form of primary immunodeficiency (such as Severe Combined Immunodeficiency Disease and AIDS).
* History of major organ autoimmune disease.
* Concurrent opportunistic infections (The experimental treatment being evaluated in this protocol depends on an intact immune system. Participants who have decreased immune-competence may be less responsive to the experimental treatment and more susceptible to its toxicities.)
* History of severe immediate hypersensitivity reaction to cyclophosphamide, fludarabine, aldesleukin or vaccines.
* Clinically significant participant history which in the judgment of the Principal Investigator (PI) would compromise the participants ability to tolerate high-dose aldesleukin.
* Antecedentes de revascularización coronaria o síntomas isquémicos.
* For select participants with a clinical history prompting cardiac evaluation: last known LVEF <= 45%.
* For select participants with a clinical history prompting pulmonary evaluation: known FEV1 <= 50% predicted.