WNT Pathway Biomarker

The Wnt signaling pathway is a complex signaling pathway responsible for the maintenance of the intestines.
Cells are rapidly lost due to the harsh nature and contents within the intestines.

WNT Pathway Biomarker

The Wnt signaling pathway is a complex signaling pathway responsible for the maintenance of the intestines. Cells are rapidly lost due to the harsh nature and contents within the intestines.

WNT Pathway Biomarker

The Wnt signaling pathway is a complex signaling pathway responsible for the maintenance of the intestines. Cells are rapidly lost due to the harsh nature and contents within the intestines.

What Is the Wnt Signaling Pathway?

The Wnt signaling pathway is like a set of instructions inside your cells that helps keep your intestines healthy. The intestines are a harsh environment, and the cells lining them wear out and die quickly. The Wnt pathway helps your body make new cells to replace the old ones.

But if something goes wrong—like a mutation (a change in the gene)—this system can stop working properly. When the pathway becomes unbalanced, it can cause cells to grow and divide out of control, which may lead to cancer.

In fact, over 90% of colorectal cancers (CRCs) have problems (mutations) in this pathway. The most common gene with a mutation is APC, followed by another gene called CTNNB1, which helps make a protein called beta-catenin. APC mutations are also linked to a genetic condition called familial adenomatous polyposis (FAP), which increases the risk of colorectal cancer.

What Is the Wnt Signaling Pathway?

The Wnt signaling pathway is like a set of instructions inside your cells that helps keep your intestines healthy. The intestines are a harsh environment, and the cells lining them wear out and die quickly. The Wnt pathway helps your body make new cells to replace the old ones.

But if something goes wrong—like a mutation (a change in the gene)—this system can stop working properly. When the pathway becomes unbalanced, it can cause cells to grow and divide out of control, which may lead to cancer.

In fact, over 90% of colorectal cancers (CRCs) have problems (mutations) in this pathway. The most common gene with a mutation is APC, followed by another gene called CTNNB1, which helps make a protein called beta-catenin. APC mutations are also linked to a genetic condition called familial adenomatous polyposis (FAP), which increases the risk of colorectal cancer.

What Is the Wnt Signaling Pathway?

The Wnt signaling pathway is like a set of instructions inside your cells that helps keep your intestines healthy. The intestines are a harsh environment, and the cells lining them wear out and die quickly. The Wnt pathway helps your body make new cells to replace the old ones.

But if something goes wrong—like a mutation (a change in the gene)—this system can stop working properly. When the pathway becomes unbalanced, it can cause cells to grow and divide out of control, which may lead to cancer.

In fact, over 90% of colorectal cancers (CRCs) have problems (mutations) in this pathway. The most common gene with a mutation is APC, followed by another gene called CTNNB1, which helps make a protein called beta-catenin. APC mutations are also linked to a genetic condition called familial adenomatous polyposis (FAP), which increases the risk of colorectal cancer.

Is the Wnt Pathway a Biomarker?

Some scientists are studying the Wnt pathway to see if it can be used as a biomarker—a signal or clue that helps doctors understand more about the cancer.

Right now, there are no official tests for the genes or proteins in the Wnt pathway when treating colorectal cancer. But researchers are working on it. They are especially interested in whether changes in these genes or proteins could help predict how the disease might behave in the future (this is called a prognostic biomarker).

Is the Wnt Pathway a Biomarker?

Some scientists are studying the Wnt pathway to see if it can be used as a biomarker—a signal or clue that helps doctors understand more about the cancer.

Right now, there are no official tests for the genes or proteins in the Wnt pathway when treating colorectal cancer. But researchers are working on it. They are especially interested in whether changes in these genes or proteins could help predict how the disease might behave in the future (this is called a prognostic biomarker).

Is the Wnt Pathway a Biomarker?

Some scientists are studying the Wnt pathway to see if it can be used as a biomarker—a signal or clue that helps doctors understand more about the cancer.

Right now, there are no official tests for the genes or proteins in the Wnt pathway when treating colorectal cancer. But researchers are working on it. They are especially interested in whether changes in these genes or proteins could help predict how the disease might behave in the future (this is called a prognostic biomarker).

What Treatments Are Available?

Currently, there are no approved treatments that directly target the Wnt signaling pathway.

However, scientists are very interested in this area. They are working hard to find drugs that could block or adjust the Wnt pathway to make cancer treatments more effective in the future.

What Treatments Are Available?

Currently, there are no approved treatments that directly target the Wnt signaling pathway.

However, scientists are very interested in this area. They are working hard to find drugs that could block or adjust the Wnt pathway to make cancer treatments more effective in the future.

What Treatments Are Available?

Currently, there are no approved treatments that directly target the Wnt signaling pathway.

However, scientists are very interested in this area. They are working hard to find drugs that could block or adjust the Wnt pathway to make cancer treatments more effective in the future.

If you’ve been diagnosed with colorectal cancer, you need to know about biomarker testing.

If you’ve been diagnosed with colorectal cancer, you need to know about biomarker testing.

If you’ve been diagnosed with colorectal cancer, you need to know about biomarker testing.

Finding Clinical Trials

Although there are no Wnt-targeting drugs on the market yet, some are being tested in clinical trials for colorectal cancer and other cancers.

You can:

  • Talk to your doctor to see if a clinical trial is right for you.
  • Use Fight CRC’s Clinical Trial Finder to explore trials for patients, including those with MSI-H colorectal cancer.
  • Read our Clinical Trials Conversations to learn more about promising studies that are worth watching.

Finding Clinical Trials

Although there are no Wnt-targeting drugs on the market yet, some are being tested in clinical trials for colorectal cancer and other cancers.

You can:

  • Talk to your doctor to see if a clinical trial is right for you.
  • Use Fight CRC’s Clinical Trial Finder to explore trials for patients, including those with MSI-H colorectal cancer.
  • Read our Clinical Trials Conversations to learn more about promising studies that are worth watching.

Finding Clinical Trials

Although there are no Wnt-targeting drugs on the market yet, some are being tested in clinical trials for colorectal cancer and other cancers.

You can:

  • Talk to your doctor to see if a clinical trial is right for you.
  • Use Fight CRC’s Clinical Trial Finder to explore trials for patients, including those with MSI-H colorectal cancer.
  • Read our Clinical Trials Conversations to learn more about promising studies that are worth watching.

Medical Review

West Virginia University

Date reviewed: May 06, 2025