Clinical Trial Finder Search Results

About the Fight CRC Clinical Trial Finder

This Trial Finder is a one-stop place to find and learn more about high-impact clinical trials for colorectal cancer patients with advanced colon or rectal cancer. Originally created by the late Dr. Tom Marsilje as a curated spreadsheet of trials, the FightCRC’s Trial Finder is a resource to find research studies that are open in your geography, and for which you may be eligible. The current data is now for metastatic, stage IV patients with both MSS and MSI-H status. The list of trials here is sourced from the ClinicalTrials.gov website and curated with Comments and Helpful Links. The searches can be focused on immunotherapy-centered trials and narrowed to studies enrolling patients who already have received immunotherapies.

Medical Disclaimer

The information contained in this website is not intended to recommend the self management of health problems, medical conditions or wellness. It is not intended to endorse or recommend any particular type of medical treatment, physician or treatment facility. Should any reader have any health care related questions, promptly call or consult your physician or healthcare provider. The information contained in this website should NOT be used by any reader to disregard medical and/or health related advice or provide a basis to delay consultation with a physician or a qualified healthcare provider. Fight Colorectal Cancer disclaims any liability based on information provided in this website.

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NCT ID	Title	Phase	Date Added	Location	Prior IO Allowed	CRC-directed	Status	Drugs	Tags
NCT ID NCT04362839	TitleRegorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer	Phase Phase 1	Date Added 2020-04-27	Location California, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Ipilimumab, Nivolumab, Regorafenib, Opdivo, Stivarga, Yervoy	Tags MSS/ MMRp
NCT ID NCT04332653	TitleNT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors	Phase Phase 1	Date Added 2020-04-03	Location Florida, United States Michigan, United States Missouri, United States North Carolina, United States Pennsylvania, United States Tennessee, United States Texas, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Active, not recruiting	Drugs NT-I7, Pembrolizumab	Tags MSS/ MMRp
NCT ID NCT04262687	TitleChemotherapy and Immunotherapy as Treatment for MSS Metastatic Colorectal Cancer With High Immune Infiltrate	Phase Phase 2	Date Added 2020-02-10	Location France	Prior IO Allowed No	CRC-directed Yes	Status Recruiting	Drugs Bevacizumab, capecitabine, oxaliplatin, Pembrolizumab	Tags MSS/ MMRp
NCT ID NCT04185883	TitleSotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)	Phase Phase 1	Date Added 2019-12-04	Location Arizona, United States California, United States Colorado, United States Connecticut, United States Florida, United States Georgia, United States Illinois, United States Indiana, United States Iowa, United States Maryland, United States Michigan, United States Missouri, United States New York, United States North Carolina, United States Ohio, United States Oregon, United States Pennsylvania, United States South Carolina, United States South Dakota, United States Tennessee, United States Texas, United States Utah, United States Virginia, United States Washington, United States Australia Austria Belgium Canada Germany Italy Japan Korea, Republic of Netherlands Spain Taiwan United Kingdom	Prior IO Allowed Yes	CRC-directed No	Status Recruiting	Drugs afatinib, AMG 404, Atezolizumab, carboplatin, pemetrexed, docetaxel, everolimus, FOLFIRI, FOLFOX, MVASI® (bevacizumab-awwb), palbociclib, panitumumab, Pembrolizumab, RMC-4630, Sotorasib, TNO155, Trametinib	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT04130854	TitleINNATE: Immunotherapy During Neoadjuvant Therapy for Rectal Cancer	Phase Phase 2	Date Added 2019-10-18	Location Arizona, United States North Carolina, United States Oregon, United States Texas, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs APX005M, mFOLFOX, and Radiation Therapy 5Gy x 5 days, mFOLFOX and Radiation Therapy 5Gy x 5 days	Tags MSS/ MMRp
NCT ID NCT04117087	TitlePooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected MMR-p Colorectal and Pancreatic Cancer	Phase Phase 1	Date Added 2019-10-07	Location Maryland, United States	Prior IO Allowed No	CRC-directed Yes	Status Recruiting	Drugs Ipilimumab, Nivolumab, Opdivo, Yervoy	Tags MSS/ MMRp
NCT ID NCT04110093	TitleRegorafenib Plus PD-1 Inhibitor in Patients With Colorectal Cancer	Phase Phase 1/Phase 2	Date Added 2019-10-01	Location China	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs Regorafenib and PD-1 inhibitor	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT04111172	TitleA Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma	Phase Phase 2	Date Added 2019-10-01	Location Pennsylvania, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Active, not recruiting	Drugs Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT04111458	TitleA Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation)	Phase Phase 1	Date Added 2019-10-01	Location Massachusetts, United States North Carolina, United States Tennessee, United States Texas, United States Germany Netherlands	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs BI 1701963, Trametinib	Tags MSS/ MMRp
NCT ID NCT04104776	TitleA Study of CPI-0209 in Patients With Advanced Solid Tumors and Lymphomas	Phase Phase 1	Date Added 2019-09-26	Location Georgia, United States Illinois, United States Maryland, United States Massachusetts, United States Michigan, United States New Jersey, United States New York, United States Ohio, United States Texas, United States Virginia, United States Washington, United States France Italy Korea, Republic of Poland Spain United Kingdom	Prior IO Allowed No	CRC-directed No	Status Recruiting	Drugs CPI-0209, CPI-0209	Tags MSI-H/ MMRd, MSS/ MMRp

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