Clinical Trial Finder Search Results

About the Fight CRC Clinical Trial Finder

This Trial Finder is a one-stop place to find and learn more about high-impact clinical trials for colorectal cancer patients with advanced colon or rectal cancer. Originally created by the late Dr. Tom Marsilje as a curated spreadsheet of trials, the FightCRC’s Trial Finder is a resource to find research studies that are open in your geography, and for which you may be eligible. The current data is now for metastatic, stage IV patients with both MSS and MSI-H status. The list of trials here is sourced from the ClinicalTrials.gov website and curated with Comments and Helpful Links. The searches can be focused on immunotherapy-centered trials and narrowed to studies enrolling patients who already have received immunotherapies.

Medical Disclaimer

The information contained in this website is not intended to recommend the self management of health problems, medical conditions or wellness. It is not intended to endorse or recommend any particular type of medical treatment, physician or treatment facility. Should any reader have any health care related questions, promptly call or consult your physician or healthcare provider. The information contained in this website should NOT be used by any reader to disregard medical and/or health related advice or provide a basis to delay consultation with a physician or a qualified healthcare provider. Fight Colorectal Cancer disclaims any liability based on information provided in this website.

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NCT ID	Title	Phase	Date Added	Location	Prior IO Allowed	CRC-directed	Status	Drugs	Tags
NCT ID NCT06066424	TitlePhase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)	Phase Phase 1	Date Added 2023-10-04	Location Texas, United States	Prior IO Allowed Yes	CRC-directed No	Status Recruiting	Drugs Cyclophosphamide, Fludarabine Phosphate, Rimiducid, TROP2-CAR-NK Cells	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06065371	TitleSacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy	Phase Phase 1	Date Added 2023-10-03	Location Michigan, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs capecitabine, Sacituzumab govetican	Tags MSS/ MMRp
NCT ID NCT06060704	TitleEnvafolimab Combined With Trifluridine/Tipiracil and Bevacizumab in the Treatment of Refractory mCRC.	Phase Phase 2	Date Added 2023-09-29	Location China	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs Bevacizumab, Envafolimab, Trifluridine/Tipiracil, Avastin, Lonsurf	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06055439	TitleA Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy	Phase Phase 1, Phase 2	Date Added 2023-09-26	Location Georgia, United States Illinois, United States Pennsylvania, United States Tennessee, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06047015	TitleIrreversible Electroporation (NanoKnife ®) and Immunotherapy for the Treatment of Stage IV Colorectal Cancer	Phase Phase 1	Date Added 2023-09-21	Location	Prior IO Allowed Yes	CRC-directed Yes	Status Not yet recruiting	Drugs	Tags MSS/ MMRp
NCT ID NCT06043713	TitleAutologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations	Phase Phase 1	Date Added 2023-09-21	Location Washington, United States	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs Bendamustine, Cyclophosphamide, Fludarabine	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06039202	TitlePhase 2 Study of CA102N Combined With TAS-102 Compared to Bevacizumab Combined With TAS-102 in Subjects With Relapsed and/or Refractory Metastatic Colorectal Cancer	Phase Phase 2	Date Added 2023-09-15	Location	Prior IO Allowed Yes	CRC-directed Yes	Status Not yet recruiting	Drugs CA102N, TAS-102	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06039384	TitleA Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation	Phase Phase 1	Date Added 2023-09-15	Location California, United States Colorado, United States Michigan, United States Texas, United States Virginia, United States Italy Spain United Kingdom	Prior IO Allowed Yes	CRC-directed Yes	Status Active, not recruiting	Drugs Adagrasib, INCB099280	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06034860	TitleStudy of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced Solid Cancer Types	Phase Phase 1	Date Added 2023-09-13	Location California, United States Indiana, United States Missouri, United States New York, United States Virginia, United States	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs MT-8421, Nivolumab, Opdivo	Tags MSI-H/ MMRd
NCT ID NCT06026774	TitleClinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Subjects With Resected Digestive System Neoplasms	Phase Phase 1	Date Added 2023-09-07	Location China	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs	Tags MSI-H/ MMRd, MSS/ MMRp

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