Clinical Trial Finder Search Results

About the Fight CRC Clinical Trial Finder

This Trial Finder is a one-stop place to find and learn more about high-impact clinical trials for colorectal cancer patients with advanced colon or rectal cancer. Originally created by the late Dr. Tom Marsilje as a curated spreadsheet of trials, the FightCRC’s Trial Finder is a resource to find research studies that are open in your geography, and for which you may be eligible. The current data is now for metastatic, stage IV patients with both MSS and MSI-H status. The list of trials here is sourced from the ClinicalTrials.gov website and curated with Comments and Helpful Links. The searches can be focused on immunotherapy-centered trials and narrowed to studies enrolling patients who already have received immunotherapies.

Medical Disclaimer

The information contained in this website is not intended to recommend the self management of health problems, medical conditions or wellness. It is not intended to endorse or recommend any particular type of medical treatment, physician or treatment facility. Should any reader have any health care related questions, promptly call or consult your physician or healthcare provider. The information contained in this website should NOT be used by any reader to disregard medical and/or health related advice or provide a basis to delay consultation with a physician or a qualified healthcare provider. Fight Colorectal Cancer disclaims any liability based on information provided in this website.

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NCT ID	Title	Phase	Date Added	Location	Prior IO Allowed	CRC-directed	Status	Drugs	Tags
NCT ID NCT06010901	TitleA Clinical Study of TQB2618 Injection Monotherapy and Combination Regimen (With Penpulimab Injection ±Anlotinib Hydrochloride Capsules) in the Four or Later Lines of Treatment of Advanced Colorectal Cancer.	Phase Phase 1	Date Added 2023-08-25	Location China	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs Anlotinib hydrochloride capsules, Penpulimab Injection, TQB2618 injection	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06011772	TitleA Phase 0 Study of EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer	Phase Early Phase 1	Date Added 2023-08-25	Location New York, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Suspended	Drugs fluorouracil, Irinotecan, Leucovorin, oxaliplatin	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06013111	TitleAn Exploratory Clinical Study Evaluating the Safety and Efficacy of Anti-CEA-CAR-T Cells Injection in Patients With CEA+ Locally Advanced and/or Metastatic Solid Tumors	Phase Phase 1	Date Added 2023-08-28	Location China	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06099821	TitleKN046 Plus Regorafenib or Apatinib in MSI-H Digestive System Cancers Resistant to PD-1/PD-L1 Blockade	Phase Phase 2	Date Added 2023-10-25	Location China	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs apatinib, KN046, Regorafenib	Tags MSI-H/ MMRd
NCT ID NCT06102902	TitleTesting the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Refractory BRAF V600E mCRC	Phase Phase 1	Date Added 2023-10-26	Location California, United States Kansas, United States Ohio, United States Oklahoma, United States Texas, United States Virginia, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs BET Bromodomain Inhibitor ZEN-3694, encorafenib	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06105021	TitlePhase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor	Phase Phase 1, Phase 2	Date Added 2023-10-27	Location California, United States Connecticut, United States New York, United States Oregon, United States Tennessee, United States Texas, United States Washington, United States Wisconsin, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs AFNT-211	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT03223779	TitleStudy of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer	Phase Phase 1	Date Added 2017-07-21	Location Massachusetts, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06120127	TitlePostoperative Chemotherapy With/Without Radiotherapy and Immunotherapy for Colorectal Liver Metastases With High Risk of Locally Recurrence	Phase Phase 2	Date Added 2023-11-07	Location China	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs Chemotherapy, PD-1 antibody	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06253520	TitleAutologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer	Phase Phase 1	Date Added 2024-02-12	Location Maryland, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs Aldesleukin, Cyclophosphamide, Fludarabine	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06302062	TitlePhase I Clinical Study of Tumor-associated Lymph Node T Cell Therapy for Advanced Solid Tumors	Phase Phase 1	Date Added 2024-03-08	Location China	Prior IO Allowed Yes	CRC-directed No	Status Recruiting	Drugs Cyclophosphamide, IL-2, Serplulimab Injection, Tumor Associated Lymph node T cell	Tags MSI-H/ MMRd, MSS/ MMRp

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