Clinical Trial Finder Search Results

About the Fight CRC Clinical Trial Finder

This Trial Finder is a one-stop place to find and learn more about high-impact clinical trials for colorectal cancer patients with advanced colon or rectal cancer. Originally created by the late Dr. Tom Marsilje as a curated spreadsheet of trials, the FightCRC’s Trial Finder is a resource to find research studies that are open in your geography, and for which you may be eligible. The current data is now for metastatic, stage IV patients with both MSS and MSI-H status. The list of trials here is sourced from the ClinicalTrials.gov website and curated with Comments and Helpful Links. The searches can be focused on immunotherapy-centered trials and narrowed to studies enrolling patients who already have received immunotherapies.

Medical Disclaimer

The information contained in this website is not intended to recommend the self management of health problems, medical conditions or wellness. It is not intended to endorse or recommend any particular type of medical treatment, physician or treatment facility. Should any reader have any health care related questions, promptly call or consult your physician or healthcare provider. The information contained in this website should NOT be used by any reader to disregard medical and/or health related advice or provide a basis to delay consultation with a physician or a qualified healthcare provider. Fight Colorectal Cancer disclaims any liability based on information provided in this website.

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NCT ID	Title	Phase	Date Added	Location	Prior IO Allowed	CRC-directed	Status	Drugs	Tags
NCT ID NCT03940820	TitleClinical Research of ROBO1 Specific CAR-NK Cells on Patients With Solid Tumors	Phase Phase 1/Phase 2	Date Added 2019-05-07	Location China	Prior IO Allowed No	CRC-directed No	Status Recruiting	Drugs ROBO1 CAR-NK cells	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT03795311	TitleEvaluation of the Efficacy and the Safety of FOLFIRINOX3 Bevacizumab Treatment in Patients With Colorectal Cancer (FOLFIRINOX 3)	Phase Phase 1, Phase 2	Date Added 2019-01-07	Location France	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs FOLFIRINOX Bevacizumab	Tags MSS/ MMRp
NCT ID NCT03874897	TitleChimeric Antigen Receptor T Cells Targeting claudin18.2 in Solid Tumors.	Phase Phase 1	Date Added 2019-03-14	Location China	Prior IO Allowed No	CRC-directed No	Status Recruiting	Drugs CAR-CLDN18.2 T-Cells, Chemotherapy, PD-1 Monoclonal Antibody	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT04046445	TitlePhase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer	Phase Phase 1	Date Added 2019-08-06	Location Arizona, United States California, United States Colorado, United States New York, United States North Carolina, United States Texas, United States Belgium Germany Switzerland	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs ATP128, BI 754091, VSV-GP128	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT03867799	TitleiSCORE: Immunotherapy Sequencing in COlon and REctal Cancer	Phase Phase 2	Date Added 2019-03-08	Location United Kingdom	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Nivolumab	Tags MSS/ MMRp
NCT ID NCT02499328	TitleStudy to Assess MEDI4736 With Either AZD9150 or AZD5069 in Advanced Solid Tumors & Relapsed Metastatic Squamous Cell Carcinoma of Head & Neck	Phase Phase 1, Phase 2	Date Added 2015-07-16	Location Alabama, United States California, United States Colorado, United States Florida, United States Indiana, United States Massachusetts, United States Michigan, United States Montana, United States New Jersey, United States Ohio, United States Texas, United States Virginia, United States Washington, United States Belgium Germany Italy Spain United Kingdom	Prior IO Allowed No	CRC-directed No	Status Active, not recruiting	Drugs AZD5069, AZD9150, MEDI4736, tremelimumab (treme)	Tags MSS/ MMRp
NCT ID NCT04017650	TitleEncorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer	Phase Phase 1, Phase 2	Date Added 2019-07-12	Location Texas, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs cetuximab, encorafenib, Nivolumab	Tags MSS/ MMRp
NCT ID NCT03711058	TitleStudy of PI3Kinase Inhibition (Copanlisib) and Anti-PD-1 Antibody Nivolumab in Relapsed/Refractory Solid Tumors With Expansions in Mismatch-repair Proficient (MSS) Colorectal Cancer	Phase Phase 1, Phase 2	Date Added 2018-10-18	Location Maryland, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Copanlisib, Nivolumab	Tags MSS/ MMRp
NCT ID NCT05167409	TitleA Study of ALX148 With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer	Phase Phase 2	Date Added 2021-12-22	Location Arizona, United States Colorado, United States New Jersey, United States Virginia, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs ALX148, cetuximab, Evorpacept (ALX148), Pembrolizumab, Erbitux, Keytruda	Tags MSS/ MMRp
NCT ID NCT03727763	TitleCetuximab and Vemurafenib Plus FOLFIRI for BRAF V600E Mutated Advanced Colorectal Cancer (IMPROVEMENT)	Phase Phase 2	Date Added 2018-11-01	Location China	Prior IO Allowed No	CRC-directed Yes	Status Recruiting	Drugs cetuximab, Vemurafenib	Tags MSI-H/ MMRd, MSS/ MMRp

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