Clinical Trial Finder Search Results

About the Fight CRC Clinical Trial Finder

This Trial Finder is a one-stop place to find and learn more about high-impact clinical trials for colorectal cancer patients with advanced colon or rectal cancer. Originally created by the late Dr. Tom Marsilje as a curated spreadsheet of trials, the FightCRC’s Trial Finder is a resource to find research studies that are open in your geography, and for which you may be eligible. The current data is now for metastatic, stage IV patients with both MSS and MSI-H status. The list of trials here is sourced from the ClinicalTrials.gov website and curated with Comments and Helpful Links. The searches can be focused on immunotherapy-centered trials and narrowed to studies enrolling patients who already have received immunotherapies.

Medical Disclaimer

The information contained in this website is not intended to recommend the self management of health problems, medical conditions or wellness. It is not intended to endorse or recommend any particular type of medical treatment, physician or treatment facility. Should any reader have any health care related questions, promptly call or consult your physician or healthcare provider. The information contained in this website should NOT be used by any reader to disregard medical and/or health related advice or provide a basis to delay consultation with a physician or a qualified healthcare provider. Fight Colorectal Cancer disclaims any liability based on information provided in this website.

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NCT ID	Title	Phase	Date Added	Location	Prior IO Allowed	CRC-directed	Status	Drugs	Tags
NCT ID NCT03519412	TitlePembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status	Phase Phase 2	Date Added 2018-05-09	Location Italy	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs pembrolizumab (treatment), temozolomide (induction),, Keytruda, Temodar	Tags MSS/ MMRp
NCT ID NCT02886585	TitlePembrolizumab In Central Nervous System Metastases	Phase Phase 2	Date Added 2016-09-01	Location Massachusetts, United States	Prior IO Allowed No	CRC-directed No	Status Active, not recruiting	Drugs Pembrolizumab	Tags MSS/ MMRp
NCT ID NCT04963283	TitleStudy of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer	Phase Phase 2	Date Added 2021-07-15	Location Colorado, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Cabozantinib, Nivolumab	Tags MSS/ MMRp
NCT ID NCT03977090	TitleGeptanolimab(GB226) Combined With Fruquintinib in the Treatment of Metastatic Colorectal Cancer	Phase Phase 1	Date Added 2019-06-06	Location China	Prior IO Allowed No	CRC-directed Yes	Status Recruiting	Drugs Fruquintinib, Geptanolimab Injection, Elunate	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT02298959	TitleTesting the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer	Phase Phase 1	Date Added 2014-11-24	Location Florida, United States Maryland, United States Massachusetts, United States Canada	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Pembrolizumab, Ziv-Aflibercept, Keytruda, Zaltrap	Tags MSS/ MMRp
NCT ID NCT03844750	TitlePembrolizumab After Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and Who Are Undergoing Liver Surgery	Phase Phase 2	Date Added 2019-02-18	Location California, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Pembrolizumab, Vactosertib, Keytruda	Tags MSS/ MMRp
NCT ID NCT05243862	TitleSafety and Activity of PolyPEPI1018 Plus Atezolizumab in Colorectal Cancer.	Phase Phase 2	Date Added 2022-02-17	Location Arizona, United States Florida, United States Minnesota, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Atezolizumab, PolyPEPI1018, Tecentriq	Tags MSS/ MMRp
NCT ID NCT04776148	TitleStudy of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017)	Phase Phase 3	Date Added 2021-03-01	Location California, United States Georgia, United States Illinois, United States Maryland, United States Michigan, United States Montana, United States Oregon, United States Pennsylvania, United States Virginia, United States Washington, United States Argentina Australia Canada China Denmark Germany Israel Japan Korea, Republic of Russian Federation Spain Taiwan Turkey United Kingdom	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Lenvatinib, Pembrolizumab, Regorafenib, TAS-102 (trifluridine and tipiracil)	Tags MSS/ MMRp
NCT ID NCT04653480	TitleSurufatinib, Toripalimab and Chemotherapy in Second-line MT and MSS CRC	Phase Phase 2	Date Added 2020-12-04	Location China	Prior IO Allowed No	CRC-directed Yes	Status Recruiting	Drugs Chemotherapy, Surufatinib, Toripalimab	Tags MSS/ MMRp
NCT ID NCT03925662	TitleMebendazole as Adjuvant Treatment for Colon Cancer	Phase Phase 3	Date Added 2019-04-24	Location Egypt	Prior IO Allowed No	CRC-directed Yes	Status Recruiting	Drugs Folfox with avastin, Mebendazole	Tags MSI-H/ MMRd, MSS/ MMRp

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