Clinical Trial Finder Search Results

About the Fight CRC Clinical Trial Finder

This Trial Finder is a one-stop place to find and learn more about high-impact clinical trials for colorectal cancer patients with advanced colon or rectal cancer. Originally created by the late Dr. Tom Marsilje as a curated spreadsheet of trials, the FightCRC’s Trial Finder is a resource to find research studies that are open in your geography, and for which you may be eligible. The current data is now for metastatic, stage IV patients with both MSS and MSI-H status. The list of trials here is sourced from the ClinicalTrials.gov website and curated with Comments and Helpful Links. The searches can be focused on immunotherapy-centered trials and narrowed to studies enrolling patients who already have received immunotherapies.

Medical Disclaimer

The information contained in this website is not intended to recommend the self management of health problems, medical conditions or wellness. It is not intended to endorse or recommend any particular type of medical treatment, physician or treatment facility. Should any reader have any health care related questions, promptly call or consult your physician or healthcare provider. The information contained in this website should NOT be used by any reader to disregard medical and/or health related advice or provide a basis to delay consultation with a physician or a qualified healthcare provider. Fight Colorectal Cancer disclaims any liability based on information provided in this website.

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NCT ID	Title	Phase	Date Added	Location	Prior IO Allowed	CRC-directed	Status	Drugs	Tags
NCT ID NCT01351103	TitleA Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands	Phase Phase 1	Date Added 2011-05-10	Location California, United States Maryland, United States Massachusetts, United States Michigan, United States Texas, United States Canada France Germany Italy Netherlands Spain	Prior IO Allowed Yes	CRC-directed Yes	Status Completed	Drugs LGK974, PDR001	Tags MSS/ MMRp
NCT ID NCT03868228	TitlePIPAC for the Treatment of Colorectal Peritoneal Metastases	Phase Phase 1	Date Added 2019-03-11	Location United Kingdom	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT05319314	TitleGCC19CART for Patients With Metastatic Colorectal Cancer	Phase Phase 1	Date Added 2022-04-08	Location California, United States Colorado, United States Massachusetts, United States Michigan, United States Texas, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs GCC19CART	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT02869217	TitleStudy of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors	Phase Phase 1	Date Added 2016-08-16	Location Canada	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs Cyclophosphamide, Fludarabine, TBI-1301	Tags MSS/ MMRp
NCT ID NCT05194735	TitlePhase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors	Phase Phase 1, Phase 2	Date Added 2022-01-18	Location Texas, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Terminated	Drugs Aldesleukin (IL-2), Neoantigen specific TCR-T cell drug product	Tags MSS/ MMRp
NCT ID NCT02888743	TitleDurvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer	Phase Phase 2	Date Added 2016-09-05	Location Arizona, United States California, United States Connecticut, United States Florida, United States Georgia, United States Kentucky, United States Maryland, United States Massachusetts, United States Michigan, United States Minnesota, United States Missouri, United States New Jersey, United States North Carolina, United States Ohio, United States Pennsylvania, United States Tennessee, United States Virginia, United States Wisconsin, United States Canada	Prior IO Allowed Yes	CRC-directed Yes	Status Active, not recruiting	Drugs durvalumab, Tremelimumab	Tags MSS/ MMRp
NCT ID NCT03545815	TitleStudy of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Mesothelin-directed CAR-T Cells in Patients With Mesothelin Positive Multiple Solid Tumors.	Phase Phase 1	Date Added 2018-06-04	Location China	Prior IO Allowed Yes	CRC-directed No	Status Recruiting	Drugs anti-mesothelin CAR-T cells	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT03388632	TitleRecombinant Interleukin-15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in People With Refractory Cancers	Phase Phase 1	Date Added 2018-01-03	Location Maryland, United States	Prior IO Allowed Yes	CRC-directed No	Status Completed	Drugs Ipilimumab, Nivolumab, rhIL-15, Opdivo, Yervoy	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT02484404	TitlePhase I/II Study of the Anti-Programmed Death Ligand-1 Durvalumab Antibody (MEDI4736) in Combination With Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Can…	Phase Phase 1, Phase 2	Date Added 2015-06-29	Location Maryland, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Active, not recruiting	Drugs Cediranib, durvalumab, Olaparib	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT03547999	TitleA Trial of Perioperative CV301 Vaccination in Combination With Nivolumab and Systemic Chemotherapy for Metastatic CRC	Phase Phase 2	Date Added 2018-06-06	Location California, United States Florida, United States Kansas, United States New Jersey, United States Ohio, United States Oregon, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Terminated	Drugs FPV-CV301, mFOLFOX6, MVA-BN-CV301, Nivolumab	Tags MSS/ MMRp

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