Clinical Trial Finder Search Results

About the Fight CRC Clinical Trial Finder

This Trial Finder is a one-stop place to find and learn more about high-impact clinical trials for colorectal cancer patients with advanced colon or rectal cancer. Originally created by the late Dr. Tom Marsilje as a curated spreadsheet of trials, the FightCRC’s Trial Finder is a resource to find research studies that are open in your geography, and for which you may be eligible. The current data is now for metastatic, stage IV patients with both MSS and MSI-H status. The list of trials here is sourced from the ClinicalTrials.gov website and curated with Comments and Helpful Links. The searches can be focused on immunotherapy-centered trials and narrowed to studies enrolling patients who already have received immunotherapies.

Medical Disclaimer

The information contained in this website is not intended to recommend the self management of health problems, medical conditions or wellness. It is not intended to endorse or recommend any particular type of medical treatment, physician or treatment facility. Should any reader have any health care related questions, promptly call or consult your physician or healthcare provider. The information contained in this website should NOT be used by any reader to disregard medical and/or health related advice or provide a basis to delay consultation with a physician or a qualified healthcare provider. Fight Colorectal Cancer disclaims any liability based on information provided in this website.

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NCT ID	Title	Phase	Date Added	Location	Prior IO Allowed	CRC-directed	Status	Drugs	Tags
NCT ID NCT03785249	TitlePhase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1	Phase Phase 1	Date Added 2018-12-24	Location Alabama, United States Alaska, United States Arizona, United States California, United States Colorado, United States Connecticut, United States Delaware, United States Florida, United States Georgia, United States Illinois, United States Indiana, United States Iowa, United States Kansas, United States Kentucky, United States Louisiana, United States Maine, United States Maryland, United States Massachusetts, United States Michigan, United States Minnesota, United States Missouri, United States Montana, United States Nebraska, United States Nevada, United States New York, United States North Carolina, United States Ohio, United States Oklahoma, United States Oregon, United States Pennsylvania, United States South Carolina, United States Tennessee, United States Texas, United States Virginia, United States Washington, United States Wisconsin, United States Puerto Rico	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs afatinib, cetuximab, MRTX849, Pembrolizumab	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06066424	TitlePhase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)	Phase Phase 1	Date Added 2023-10-04	Location Texas, United States	Prior IO Allowed Yes	CRC-directed No	Status Recruiting	Drugs Cyclophosphamide, Fludarabine Phosphate, Rimiducid, TROP2-CAR-NK Cells	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID PG545 (pixatimod) in combination with nivolumab	TitlePG545 (pixatimod) in combination with nivolumab	Phase Phase 1	Date Added 2019-04-26	Location	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT06841159	TitlePersonalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR ) Combined With Anti-PD1，Chemotherapy and Target Therapy for Metastatic Colorectal Cancer	Phase Phase 2	Date Added 2025-03-25	Location China	Prior IO Allowed No	CRC-directed Yes	Status Recruiting	Drugs	Tags MSS/ MMRp
NCT ID NCT05349890	TitlePersonalized TCR-T: Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)	Phase Phase 1	Date Added 2022-04-27	Location Oregon, United States	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs CDX-1140, Pembrolizumab, Keytruda	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT02600949	TitlePersonalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer	Phase Phase 1	Date Added 2015-11-09	Location Texas, United States	Prior IO Allowed Yes	CRC-directed Yes	Status Recruiting	Drugs imiquimod, Pembrolizumab, Sotigalimab, Synthetic Tumor-Associated Peptide Vaccine Therapy	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT03568058	TitlePersonalized Immunotherapy in Adults With Advanced Cancers Immunotherapy in Adults With Advanced Cancers	Phase Phase 1	Date Added 2018-06-26	Location California, United States	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs Pembrolizumab, personalized vaccine, Keytruda	Tags MSS/ MMRp
NCT ID NCT04096417	TitlePemigatinib for the Treatment of Metastatic or Unresectable Colorectal Cancer Harboring FGFR Alterations	Phase Phase 2	Date Added 2019-09-19	Location Arizona, United States Georgia, United States Minnesota, United States North Carolina, United States Tennessee, United States Wisconsin, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Pemigatinib	Tags MSS/ MMRp
NCT ID NCT04014530	TitlePembrolizumab With Ataluren in Patients With Metastatic pMMR and dMMR Colorectal Carcinoma or Metastatic dMMR Endometrial Carcinoma: the ATAPEMBRO Study	Phase Phase 1	Date Added 2019-07-10	Location Netherlands	Prior IO Allowed No	CRC-directed Yes	Status Recruiting	Drugs Ataluren + Pembrolizumab, Keytruda	Tags MSS/ MMRp
NCT ID NCT03519412	TitlePembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status	Phase Phase 2	Date Added 2018-05-09	Location Italy	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs pembrolizumab (treatment), temozolomide (induction),, Keytruda, Temodar	Tags MSS/ MMRp

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