计划状态
暂停阶段
第三阶段允许先接受免疫治疗
没有CRC 指导的试验
是药物
Atezolizumab, fluorouracil, Leucovorin, oxaliplatin标签
MSI-H/ MMRd| 地点 | 位置状态 |
|---|---|
| 美国 | |
|
金曼地区医疗中心 亚利桑那州金曼 86401 |
暂停 |
|
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas 72401 |
暂停 |
|
Kaiser Permanente-Anaheim Anaheim, California 92806 |
暂停 |
|
Kaiser Permanente-Baldwin Park Baldwin Park, California 91706 |
暂停 |
|
Kaiser Permanente-Bellflower 加利福尼亚州贝尔弗洛尔 90706 |
暂停 |
|
Alta Bates Summit Medical Center-Herrick Campus Berkeley, California 94704 |
暂停 |
|
John Muir Medical Center-Concord Concord, California 94520 |
暂停 |
|
Kaiser Permanente-Fontana Fontana, California 92335 |
暂停 |
|
Kaiser Permanente South Bay 加利福尼亚州海港城 90710 |
暂停 |
|
Kaiser Permanente-Irvine Irvine, California 92618 |
暂停 |
|
Kaiser Permanente Los Angeles Medical Center 加利福尼亚州洛杉矶 90027 |
暂停 |
|
Kaiser Permanente West Los Angeles Los Angeles, California 90034 |
暂停 |
|
Fremont - Rideout Cancer Center Marysville, California 95901 |
暂停 |
|
Memorial Medical Center Modesto, California 95355 |
暂停 |
|
Kaiser Permanente-Ontario Ontario, California 91761 |
暂停 |
|
Saint Joseph Hospital - Orange 加利福尼亚州奥兰治 92868 |
暂停 |
|
加州大学尔湾分校健康/赵氏综合癌症中心 加利福尼亚州奥兰治 92868 |
暂停 |
|
Kaiser Permanente - Panorama City Panorama City, California 91402 |
暂停 |
|
Kaiser Permanente-Riverside Riverside, California 92505 |
暂停 |
|
Sutter Medical Center Sacramento Sacramento, California 95816 |
暂停 |
|
加州大学戴维斯分校综合癌症中心 加利福尼亚州萨克拉门托 95817 |
暂停 |
|
Salinas Valley Memorial Salinas, California 93901 |
暂停 |
|
Kaiser Permanente-San Diego Mission San Diego, California 92108 |
暂停 |
|
Kaiser Permanente-San Diego Zion 加利福尼亚州圣地亚哥 92120 |
暂停 |
|
Kaiser Permanente-San Marcos San Marcos, California 92078 |
暂停 |
|
John Muir Medical Center-Walnut Creek Walnut Creek, California 94598 |
暂停 |
|
Presbyterian Intercommunity Hospital Whittier, California 90602 |
暂停 |
|
Kaiser Permanente-Woodland Hills Woodland Hills, California 91367 |
暂停 |
|
Rocky Mountain Cancer Centers-Aurora 科罗拉多州奥罗拉 80012 |
暂停 |
|
科罗拉多大学医院 科罗拉多州奥罗拉 80045 |
暂停 |
|
Boulder Community Hospital Boulder, Colorado 80301 |
暂停 |
|
Rocky Mountain Cancer Centers-Boulder Boulder, Colorado 80304 |
暂停 |
|
Penrose-Saint Francis Healthcare 科罗拉多州科罗拉多斯普林斯 80907 |
暂停 |
|
UCHealth Memorial Hospital Central Colorado Springs, Colorado 80909 |
暂停 |
|
Memorial Hospital North Colorado Springs, Colorado 80920 |
暂停 |
|
Denver Health Medical Center 科罗拉多州丹佛市 80204 |
暂停 |
|
National Jewish Health-Main Campus Denver, Colorado 80206 |
暂停 |
|
AdventHealth Porter Denver, Colorado 80210 |
暂停 |
|
Rocky Mountain Cancer Centers-Midtown 科罗拉多州丹佛 80218 |
暂停 |
|
Saint Joseph Hospital - Cancer Centers of Colorado 科罗拉多州丹佛 80218 |
暂停 |
|
Rocky Mountain Cancer Centers-Rose Denver, Colorado 80220 |
暂停 |
|
Mountain Blue Cancer Care Center - Swedish Englewood, Colorado 80113 |
暂停 |
|
Swedish Medical Center Englewood, Colorado 80113 |
暂停 |
|
Poudre Valley Hospital Fort Collins, Colorado 80524 |
暂停 |
|
Cancer Care and Hematology-Fort Collins Fort Collins, Colorado 80528 |
暂停 |
|
National Jewish Health-Western Hematology Oncology Golden, Colorado 80401 |
暂停 |
|
Banner North Colorado Medical Center Greeley, Colorado 80631 |
暂停 |
|
UCHealth Greeley Hospital Greeley, Colorado 80631 |
暂停 |
|
Rocky Mountain Cancer Centers-Littleton Littleton, Colorado 80120 |
暂停 |
|
Rocky Mountain Cancer Centers-Sky Ridge 科罗拉多州孤树 80124 |
暂停 |
|
Medical Center of the Rockies Loveland, Colorado 80538 |
暂停 |
|
Banner McKee Medical Center Loveland, Colorado 80539 |
暂停 |
|
National Jewish Health-Northern Hematology Oncology 科罗拉多州桑顿 80260 |
暂停 |
|
Intermountain Health Lutheran Hospital Wheat Ridge, Colorado 80401 |
暂停 |
|
Danbury Hospital Danbury, Connecticut 06810 |
暂停 |
|
Hartford Hospital Hartford, Connecticut 06102 |
暂停 |
|
Midstate Medical Center Meriden, Connecticut 06451 |
暂停 |
|
The Hospital of Central Connecticut New Britain, Connecticut 06050 |
暂停 |
|
William Backus Hospital Norwich, Connecticut 06360 |
暂停 |
|
比伯南部海岸健康校园 特拉华州米尔维尔 19967 |
暂停 |
|
海伦-格雷厄姆癌症中心 特拉华州纽瓦克 19713 |
暂停 |
|
肿瘤内科血液学顾问 PA 特拉华州纽瓦克 19713 |
暂停 |
|
比伯健康校园 特拉华州雷霍博斯海滩 19971 |
暂停 |
|
Kaiser Permanente-Capitol Hill Medical Center Washington, District of Columbia 20002 |
暂停 |
|
Broward Health Medical Center Fort Lauderdale, Florida 33316 |
暂停 |
|
Regional Cancer Center-Lee Memorial Health System Fort Myers, Florida 33905 |
暂停 |
|
佛罗里达大学盖恩斯维尔健康科学中心 佛罗里达州盖恩斯维尔 32610 |
暂停 |
|
Baptist MD Anderson Cancer Center Jacksonville, Florida 32207 |
暂停 |
|
AdventHealth Orlando Orlando, Florida 32803 |
暂停 |
|
Phoebe Putney Memorial Hospital Albany, Georgia 31701 |
暂停 |
|
University Cancer and Blood Center LLC 佐治亚州雅典 30607 |
暂停 |
|
Augusta Oncology Associates PC-D'Antignac Augusta, Georgia 30901 |
暂停 |
|
Augusta Oncology Associates PC-Wheeler Augusta, Georgia 30909 |
暂停 |
|
Augusta University Medical Center Augusta, Georgia 30912 |
暂停 |
|
CTCA at Southeastern Regional Medical Center Newnan, Georgia 30265 |
暂停 |
|
Saint Alphonsus Cancer Care Center-Boise 爱达荷州博伊西 83706 |
暂停 |
|
圣卢克癌症研究所 - 博伊西 爱达荷州博伊西 83712 |
暂停 |
|
Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho 83605 |
暂停 |
|
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho 83814 |
暂停 |
|
圣卢克癌症研究所 - 弗里特兰 爱达荷州弗里特兰 83619 |
暂停 |
|
圣卢克癌症研究所 - 梅里迪安 爱达荷州梅里迪安 83642 |
暂停 |
|
Saint Alphonsus Cancer Care Center-Nampa 爱达荷州南帕 83687 |
暂停 |
|
圣卢克癌症研究所 - 南帕 爱达荷州南帕 83687 |
暂停 |
|
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho 83854 |
暂停 |
|
Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho 83864 |
暂停 |
|
圣卢克癌症研究所 - 双瀑布市 爱达荷州双瀑布市 83301 |
暂停 |
|
Illinois CancerCare-Bloomington Bloomington, Illinois 61704 |
暂停 |
|
Illinois CancerCare-Canton Canton, Illinois 61520 |
暂停 |
|
Illinois CancerCare-Carthage Carthage, Illinois 62321 |
暂停 |
|
Centralia Oncology Clinic Centralia, Illinois 62801 |
暂停 |
|
Rush University Medical Center 伊利诺伊州芝加哥 60612 |
暂停 |
|
伊利诺伊大学 伊利诺伊州芝加哥 60612 |
暂停 |
|
Carle at The Riverfront Danville, Illinois 61832 |
暂停 |
|
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois 62526 |
暂停 |
|
Illinois CancerCare-Dixon Dixon, Illinois 61021 |
暂停 |
|
Carle Physician Group-Effingham Effingham, Illinois 62401 |
暂停 |
|
Crossroads Cancer Center Effingham, Illinois 62401 |
暂停 |
|
Illinois CancerCare-Eureka Eureka, Illinois 61530 |
暂停 |
|
NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois 60201 |
暂停 |
|
Illinois CancerCare-Galesburg Galesburg, Illinois 61401 |
暂停 |
|
NorthShore University HealthSystem-Glenbrook Hospital Glenview, Illinois 60026 |
暂停 |
|
NorthShore University HealthSystem-Highland Park Hospital Highland Park, Illinois 60035 |
暂停 |
|
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois 61443 |
暂停 |
|
Illinois CancerCare-Macomb Macomb, Illinois 61455 |
暂停 |
|
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois 61938 |
暂停 |
|
Loyola University Medical Center Maywood, Illinois 60153 |
暂停 |
|
SSM Health Good Samaritan Mount Vernon, Illinois 62864 |
暂停 |
|
Cancer Care Center of O'Fallon O'Fallon, Illinois 62269 |
暂停 |
|
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois 61350 |
暂停 |
|
Illinois CancerCare-Pekin Pekin, Illinois 61554 |
暂停 |
|
Illinois CancerCare-Peoria 伊利诺伊州皮奥里亚 61615 |
暂停 |
|
Illinois CancerCare-Peru Peru, Illinois 61354 |
暂停 |
|
Illinois CancerCare-Princeton Princeton, Illinois 61356 |
暂停 |
|
Southern Illinois University School of Medicine Springfield, Illinois 62702 |
暂停 |
|
Springfield Clinic Springfield, Illinois 62702 |
暂停 |
|
Carle Cancer Center Urbana, Illinois 61801 |
暂停 |
|
Illinois CancerCare - Washington Washington, Illinois 61571 |
暂停 |
|
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana 46202 |
暂停 |
|
Community Cancer Center East Indianapolis, Indiana 46219 |
暂停 |
|
Community Cancer Center South Indianapolis, Indiana 46227 |
暂停 |
|
Franciscan Health Indianapolis Indianapolis, Indiana 46237 |
暂停 |
|
Community Cancer Center North Indianapolis, Indiana 46256 |
暂停 |
|
Community Howard Regional Health Kokomo, Indiana 46904 |
暂停 |
|
Franciscan Saint Elizabeth Health - Lafayette East 印第安纳州拉斐特 47905 |
暂停 |
|
Woodland Cancer Care Center Michigan City, Indiana 46360 |
暂停 |
|
Franciscan Health Mooresville Mooresville, Indiana 46158 |
暂停 |
|
Union Hospital Terre Haute, Indiana 47804 |
暂停 |
|
Mary Greeley Medical Center Ames, Iowa 50010 |
暂停 |
|
McFarland Clinic - Ames Ames, Iowa 50010 |
暂停 |
|
University of Iowa Healthcare Cancer Services Quad Cities Bettendorf, Iowa 52722 |
暂停 |
|
McFarland Clinic - Boone Boone, Iowa 50036 |
暂停 |
|
Mercy Hospital Cedar Rapids, Iowa 52403 |
暂停 |
|
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa 52403 |
暂停 |
|
西湖慈爱癌症中心 爱荷华州克莱夫 50325 |
暂停 |
|
UI Health Care Mission Cancer and Blood - West Des Moines Clinic 爱荷华州克莱夫 50325 |
暂停 |
|
UI Health Care Mission Cancer and Blood - Des Moines Clinic 爱荷华州得梅因 50309 |
暂停 |
|
Broadlawns Medical Center 爱荷华州得梅因市 50314 |
暂停 |
|
梅西医疗中心 - 得梅因 爱荷华州得梅因市 50314 |
暂停 |
|
UI Health Care Mission Cancer and Blood - Laurel Clinic 爱荷华州得梅因市 50314 |
暂停 |
|
McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa 50501 |
暂停 |
|
Trinity Regional Medical Center Fort Dodge, Iowa 50501 |
暂停 |
|
爱荷华大学/霍尔登综合癌症中心 爱荷华州爱荷华市 52242 |
暂停 |
|
McFarland Clinic - Jefferson Jefferson, Iowa 50129 |
暂停 |
|
McFarland Clinic - Marshalltown Marshalltown, Iowa 50158 |
暂停 |
|
西湖区仁慈医疗中心 爱荷华州西得梅因 50266 |
暂停 |
|
HaysMed Hays, Kansas 67601 |
暂停 |
|
Lawrence Memorial Hospital Lawrence, Kansas 66044 |
暂停 |
|
The University of Kansas Cancer Center - Olathe Olathe, Kansas 66061 |
暂停 |
|
Salina Regional Health Center Salina, Kansas 67401 |
暂停 |
|
University of Kansas Health System Saint Francis Campus Topeka, Kansas 66606 |
暂停 |
|
University of Kansas Hospital-Westwood Cancer Center 堪萨斯州韦斯特伍德 66205 |
暂停 |
|
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas 67208 |
暂停 |
|
Cancer Center of Kansas - Wichita Wichita, Kansas 67214 |
暂停 |
|
Flaget Memorial Hospital Bardstown, Kentucky 40004 |
暂停 |
|
Baptist Health Lexington Lexington, Kentucky 40503 |
暂停 |
|
Saint Joseph Hospital East Lexington, Kentucky 40509 |
暂停 |
|
肯塔基大学/马基癌症中心 肯塔基州列克星敦 40536 |
暂停 |
|
Norton Hospital Pavilion and Medical Campus 肯塔基州路易斯维尔 40202 |
暂停 |
|
Norton Audubon Hospital and Medical Campus Louisville, Kentucky 40217 |
暂停 |
|
Norton Brownsboro Hospital and Medical Campus Louisville, Kentucky 40241 |
暂停 |
|
Ochsner Medical Center Kenner Kenner, Louisiana 70065 |
暂停 |
|
Ochsner Medical Center Jefferson New Orleans, Louisiana 70121 |
暂停 |
|
Harold Alfond Center for Cancer Care Augusta, Maine 04330 |
暂停 |
|
Eastern Maine Medical Center Bangor, Maine 04401 |
暂停 |
|
MaineHealth Waldo Hospital Belfast, Maine 04915 |
暂停 |
|
MaineHealth Maine Medical Center - Biddeford 缅因州比迪福德 04005 |
暂停 |
|
Lafayette Family Cancer Center-EMMC Brewer, Maine 04412 |
暂停 |
|
Penobscot Bay Medical Center Rockport, Maine 04856 |
暂停 |
|
MaineHealth Cancer Care and IV Therapy - Sanford Sanford, Maine 04073 |
暂停 |
|
MaineHealth Cancer Care and IV Therapy - South Portland South Portland, Maine 04106 |
暂停 |
|
Kaiser Permanente-Woodlawn Medical Center Baltimore, Maryland 21244 |
暂停 |
|
University of Maryland Shore Medical Center at Easton Easton, Maryland 21601 |
暂停 |
|
Kaiser Permanente-Gaithersburg Medical Center Gaithersburg, Maryland 20879 |
暂停 |
|
Kaiser Permanente - Largo Medical Center Largo, Maryland 20774 |
暂停 |
|
Kaiser Permanente Lutherville - Timonium Medical Center 马里兰州卢瑟维尔 21093 |
暂停 |
|
丹娜法伯癌症研究所 马萨诸塞州波士顿 02215 |
暂停 |
|
Lowell General Hospital Lowell, Massachusetts 01854 |
暂停 |
|
三一健康圣约瑟夫慈善医院安娜堡分院 密歇根州安阿伯市 48106 |
暂停 |
|
McLaren Cancer Institute-Bay City Bay City, Michigan 48706 |
暂停 |
|
McLaren Cancer Institute-Bloomfield Bloomfield, Michigan 48302 |
暂停 |
|
三一健康 IHA 医疗集团血液肿瘤科 - 布莱顿 密歇根州布莱顿 48114 |
暂停 |
|
布莱顿三一健康医疗中心 密歇根州布莱顿 48114 |
暂停 |
|
Henry Ford Cancer Institute-Downriver Brownstown, Michigan 48183 |
暂停 |
|
三一健康 IHA 医疗集团血液肿瘤科 - 广州 密歇根州坎顿 48188 |
暂停 |
|
三一健康医疗中心 - 广州 密歇根州坎顿 48188 |
暂停 |
|
切尔西医院 密歇根州切尔西 48118 |
暂停 |
|
三一健康 IHA 医疗集团血液肿瘤科 - 切尔西医院 密歇根州切尔西 48118 |
暂停 |
|
Hematology Oncology Consultants-Clarkston Clarkston, Michigan 48346 |
暂停 |
|
McLaren Cancer Institute-Clarkston Clarkston, Michigan 48346 |
暂停 |
|
Newland Medical Associates-Clarkston Clarkston, Michigan 48346 |
暂停 |
|
Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan 48038 |
暂停 |
|
Henry Ford Medical Center-Fairlane Dearborn, Michigan 48126 |
暂停 |
|
Wayne State University/Karmanos Cancer Institute 密歇根州底特律 48201 |
暂停 |
|
亨利福特医院 密歇根州底特律 48202 |
暂停 |
|
Weisberg Cancer Treatment Center 密歇根州法明顿希尔斯 48334 |
暂停 |
|
McLaren Cancer Institute-Flint Flint, Michigan 48532 |
暂停 |
|
Singh and Arora Hematology Oncology PC Flint, Michigan 48532 |
暂停 |
|
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan 49503 |
暂停 |
|
Allegiance Health Jackson, Michigan 49201 |
暂停 |
|
West Michigan Cancer Center Kalamazoo, Michigan 49007 |
暂停 |
|
Karmanos Cancer Institute at McLaren Greater Lansing Lansing, Michigan 48910 |
暂停 |
|
密歇根大学健康中心 - 斯帕罗-兰辛 密歇根州兰辛 48912 |
暂停 |
|
McLaren Cancer Institute-Lapeer Region Lapeer, Michigan 48446 |
暂停 |
|
Hope Cancer Clinic 密歇根州利沃尼亚 48154 |
暂停 |
|
三一健康圣玛丽慈悲利沃尼亚医院 密歇根州利沃尼亚 48154 |
暂停 |
|
McLaren Cancer Institute-Macomb Mount Clemens, Michigan 48043 |
暂停 |
|
McLaren Cancer Institute-Central Michigan Mount Pleasant, Michigan 48858 |
暂停 |
|
Henry Ford Medical Center-Columbus Novi, Michigan 48377 |
暂停 |
|
McLaren Cancer Institute-Northern Michigan Petoskey, Michigan 49770 |
暂停 |
|
Newland Medical Associates-Pontiac Pontiac, Michigan 48341 |
暂停 |
|
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan 48341 |
暂停 |
|
McLaren-Port Huron Port Huron, Michigan 48060 |
暂停 |
|
MyMichigan Medical Center Saginaw Saginaw, Michigan 48601 |
暂停 |
|
Oncology Hematology Associates of Saginaw Valley PC Saginaw, Michigan 48604 |
暂停 |
|
MyMichigan Medical Center Tawas Tawas City, Michigan 48764 |
暂停 |
|
Munson Medical Center Traverse City, Michigan 49684 |
暂停 |
|
Henry Ford West Bloomfield Hospital West Bloomfield, Michigan 48322 |
暂停 |
|
Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan 48661 |
暂停 |
|
三一健康 IHA 医疗集团血液肿瘤学安阿伯校区 密歇根州伊普西兰蒂 48197 |
暂停 |
|
桑福德-乔-卢肯癌症中心 明尼苏达州贝米吉 56601 |
暂停 |
|
Minnesota Oncology - Burnsville Burnsville, Minnesota 55337 |
暂停 |
|
Essentia Health - Deer River Clinic Deer River, Minnesota 56636 |
暂停 |
|
Essentia Health Cancer Center Duluth, Minnesota 55805 |
暂停 |
|
Essentia Health Hibbing Clinic Hibbing, Minnesota 55746 |
暂停 |
|
Minnesota Oncology Hematology PA-Maplewood 明尼苏达州枫林市 55109 |
暂停 |
|
Saint John's Hospital - Healtheast 明尼苏达州枫林市 55109 |
暂停 |
|
Hennepin County Medical Center 明尼苏达州明尼阿波利斯市 55415 |
暂停 |
|
Health Partners Inc Minneapolis, Minnesota 55454 |
暂停 |
|
Regions Hospital 明尼苏达州圣保罗 55101 |
暂停 |
|
United Hospital 明尼苏达州圣保罗 55102 |
暂停 |
|
Essentia Health Sandstone Sandstone, Minnesota 55072 |
暂停 |
|
Essentia Health Virginia Clinic Virginia, Minnesota 55792 |
暂停 |
|
浸信会癌症中心-格林纳达 密西西比州格林纳达 38901 |
暂停 |
|
浸信会纪念医院和癌症中心--尤尼恩县 密西西比州新奥尔巴尼 38652 |
暂停 |
|
浸信会纪念医院和癌症中心-牛津 密西西比州牛津 38655 |
暂停 |
|
浸信会纪念医院和癌症中心-德索托 密西西比州南黑文 38671 |
暂停 |
|
Saint Louis Cancer and Breast Institute-Ballwin Ballwin, Missouri 63011 |
暂停 |
|
Saint Francis Medical Center Cape Girardeau, Missouri 63703 |
暂停 |
|
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia, Missouri 65212 |
暂停 |
|
Freeman Health System Joplin, Missouri 64804 |
暂停 |
|
Mercy Hospital Joplin Joplin, Missouri 64804 |
暂停 |
|
University Health Truman Medical Center Kansas City, Missouri 64108 |
暂停 |
|
Saint Louis Cancer and Breast Institute-South City Saint Louis, Missouri 63109 |
暂停 |
|
圣路易斯仁慈医院 密苏里州圣路易斯 63141 |
暂停 |
|
Community Hospital of Anaconda Anaconda, Montana 59711 |
暂停 |
|
比林斯诊所癌症中心 蒙大拿州比林斯 59101 |
暂停 |
|
Bozeman Health Deaconess Hospital Bozeman, Montana 59715 |
暂停 |
|
Benefis Sletten 癌症研究所 蒙大拿州大瀑布 59405 |
暂停 |
|
Great Falls Clinic 蒙大拿州大瀑布 59405 |
暂停 |
|
Saint Peter's Community Hospital Helena, Montana 59601 |
暂停 |
|
Logan Health Medical Center Kalispell, Montana 59901 |
暂停 |
|
Community Medical Center Missoula, Montana 59804 |
暂停 |
|
内布拉斯加卫理公会医院 内布拉斯加州奥马哈 68114 |
暂停 |
|
OptumCare Cancer Care at Seven Hills 内华达州亨德森 89052 |
暂停 |
|
OptumCare Cancer Care at Charleston Las Vegas, Nevada 89102 |
暂停 |
|
OptumCare Cancer Care at MountainView 内华达州拉斯维加斯 89128 |
暂停 |
|
OptumCare Cancer Care at Fort Apache 内华达州拉斯维加斯 89148 |
暂停 |
|
仁爱地区医疗中心 内华达州雷诺 89502 |
暂停 |
|
达特茅斯希区柯克医疗中心/达特茅斯癌症中心 新罕布什尔州黎巴嫩 03756 |
暂停 |
|
Dartmouth Cancer Center - Manchester Manchester, New Hampshire 03102 |
暂停 |
|
Dartmouth Cancer Center - Nashua Nashua, New Hampshire 03063 |
暂停 |
|
The Cancer Institute of New Jersey Hamilton Hamilton, New Jersey 08690 |
暂停 |
|
Morristown Medical Center Morristown, New Jersey 07960 |
暂停 |
|
新泽西州拉特格斯癌症研究所 新泽西州新不伦瑞克 08903 |
暂停 |
|
The Valley Hospital - Luckow Pavilion Paramus, New Jersey 07652 |
暂停 |
|
Valley Health System Ridgewood Campus Ridgewood, New Jersey 07450 |
暂停 |
|
Robert Wood Johnson University Hospital Somerset Somerville, New Jersey 08876 |
暂停 |
|
Overlook Hospital Summit, New Jersey 07902 |
暂停 |
|
新墨西哥大学癌症中心 新墨西哥州阿尔伯克基 87106 |
暂停 |
|
Presbyterian Kaseman Hospital Albuquerque, New Mexico 87110 |
暂停 |
|
Memorial Medical Center-Las Cruces Las Cruces, New Mexico 88011 |
暂停 |
|
Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho, New Mexico 87124 |
暂停 |
|
Roswell Park Cancer Institute Buffalo, New York 14263 |
暂停 |
|
Arnot Ogden Medical Center/Falck Cancer Center Elmira, New York 14905 |
暂停 |
|
诺斯韦尔健康/高级医学中心 纽约州成功湖 11042 |
暂停 |
|
Laura and Isaac Perlmutter Cancer Center at NYU Langone 纽约州纽约市 10016 |
暂停 |
|
罗切斯特大学 纽约州罗切斯特 14642 |
暂停 |
|
Dickstein Cancer Treatment Center 纽约州怀特普莱恩斯 10601 |
暂停 |
|
UNC 莱恩伯格综合癌症中心 北卡罗来纳州教堂山 27599 |
暂停 |
|
Southeastern Medical Oncology Center-Clinton Clinton, North Carolina 28328 |
暂停 |
|
Southeastern Medical Oncology Center-Goldsboro 北卡罗来纳州戈兹伯勒 27534 |
暂停 |
|
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina 28791 |
暂停 |
|
Southeastern Medical Oncology Center-Jacksonville Jacksonville, North Carolina 28546 |
暂停 |
|
ECU Health Oncology Kenansville Kenansville, North Carolina 28349 |
暂停 |
|
ECU Health Oncology Kinston Kinston, North Carolina 28501 |
暂停 |
|
FirstHealth of the Carolinas-Moore Regional Hospital 北卡罗来纳州松赫斯特 28374 |
暂停 |
|
ECU Health Oncology Richlands Richlands, North Carolina 28574 |
暂停 |
|
Wake Forest University Health Sciences Winston-Salem, North Carolina 27157 |
暂停 |
|
桑福德俾斯麦医疗中心 北达科他州俾斯麦 58501 |
暂停 |
|
桑福德百老汇医疗中心 北达科他州法戈 58122 |
暂停 |
|
桑福德罗杰-马里斯癌症中心 北达科他州法戈 58122 |
暂停 |
|
Altru Cancer Center Grand Forks, North Dakota 58201 |
暂停 |
|
Cleveland Clinic Akron General Akron, Ohio 44307 |
暂停 |
|
Strecker Cancer Center-Belpre Belpre, Ohio 45714 |
暂停 |
|
代顿医生有限责任公司-迈阿密谷南部 俄亥俄州森特维尔 45459 |
暂停 |
|
迈阿密谷医院南院 俄亥俄州森特维尔 45459 |
暂停 |
|
Adena Regional Medical Center Chillicothe, Ohio 45601 |
暂停 |
|
University of Cincinnati Cancer Center-UC Medical Center 俄亥俄州辛辛那提 45219 |
暂停 |
|
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland, Ohio 44111 |
暂停 |
|
俄亥俄州立大学综合癌症中心 俄亥俄州哥伦布市 43210 |
暂停 |
|
Mount Carmel East Hospital Columbus, Ohio 43213 |
暂停 |
|
Columbus Oncology and Hematology Associates Inc Columbus, Ohio 43214 |
暂停 |
|
Riverside Methodist Hospital Columbus, Ohio 43214 |
暂停 |
|
Grant Medical Center Columbus, Ohio 43215 |
暂停 |
|
马克-H-赞美诗中心 俄亥俄州哥伦布市 43219 |
暂停 |
|
Mount Carmel Health Center West Columbus, Ohio 43222 |
暂停 |
|
Doctors Hospital Columbus, Ohio 43228 |
暂停 |
|
迈阿密谷医院 俄亥俄州代顿 45409 |
暂停 |
|
Delaware Health Center-Grady Cancer Center Delaware, Ohio 43015 |
暂停 |
|
Grady Memorial Hospital Delaware, Ohio 43015 |
暂停 |
|
Greater Dayton Cancer Center Kettering, Ohio 45409 |
暂停 |
|
Fairfield Medical Center Lancaster, Ohio 43130 |
暂停 |
|
俄亥俄健康曼斯菲尔德医院 俄亥俄州曼斯菲尔德 44903 |
暂停 |
|
Cleveland Clinic Cancer Center Mansfield Mansfield, Ohio 44906 |
暂停 |
|
Marietta Memorial Hospital Marietta, Ohio 45750 |
暂停 |
|
OhioHealth Marion General Hospital Marion, Ohio 43302 |
暂停 |
|
Hillcrest Hospital Cancer Center Mayfield Heights, Ohio 44124 |
暂停 |
|
Knox Community Hospital Mount Vernon, Ohio 43050 |
暂停 |
|
Licking Memorial Hospital Newark, Ohio 43055 |
暂停 |
|
Southern Ohio Medical Center Portsmouth, Ohio 45662 |
暂停 |
|
North Coast Cancer Care Sandusky, Ohio 44870 |
暂停 |
|
ProMedica Flower Hospital Sylvania, Ohio 43560 |
暂停 |
|
South Pointe Hospital Warrensville Heights, Ohio 44122 |
暂停 |
|
University of Cincinnati Cancer Center-West Chester West Chester, Ohio 45069 |
暂停 |
|
Saint Ann's Hospital Westerville, Ohio 43081 |
暂停 |
|
Genesis Healthcare System Cancer Care Center Zanesville, Ohio 43701 |
暂停 |
|
Cancer Centers of Southwest Oklahoma Research 俄克拉荷马州劳顿 73505 |
暂停 |
|
俄克拉荷马大学健康科学中心 俄克拉荷马州俄克拉荷马城 73104 |
暂停 |
|
美国癌症治疗中心 Tulsa, Oklahoma 74133 |
暂停 |
|
Oklahoma Cancer Specialists and Research Institute-Tulsa 俄克拉荷马州塔尔萨 74146 |
暂停 |
|
Saint Charles Health System 俄勒冈州本德 97701 |
暂停 |
|
Clackamas Radiation Oncology Center Clackamas, Oregon 97015 |
暂停 |
|
Providence Cancer Institute Clackamas Clinic Clackamas, Oregon 97015 |
暂停 |
|
Providence Newberg Medical Center Newberg, Oregon 97132 |
暂停 |
|
Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon 97914 |
暂停 |
|
Providence Willamette Falls Medical Center Oregon City, Oregon 97045 |
暂停 |
|
普罗维登斯波特兰医疗中心 俄勒冈州波特兰 97213 |
暂停 |
|
Providence Saint Vincent Medical Center Portland, Oregon 97225 |
暂停 |
|
Lehigh Valley Hospital-Cedar Crest 宾夕法尼亚州阿伦敦 18103 |
暂停 |
|
Saint Luke's Cancer Center - Allentown Allentown, Pennsylvania 18104 |
暂停 |
|
Saint Luke's University Hospital-Bethlehem Campus Bethlehem, Pennsylvania 18015 |
暂停 |
|
Lehigh Valley Hospital - Muhlenberg 宾夕法尼亚州伯利恒 18017 |
暂停 |
|
Saint Luke's Hospital-Anderson Campus Easton, Pennsylvania 18045 |
暂停 |
|
Saint Vincent Hospital Erie, Pennsylvania 16544 |
暂停 |
|
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg, Pennsylvania 17109 |
暂停 |
|
Jefferson Hospital Jefferson Hills, Pennsylvania 15025 |
暂停 |
|
Forbes Hospital Monroeville, Pennsylvania 15146 |
暂停 |
|
Allegheny Valley Hospital Natrona Heights, Pennsylvania 15065 |
暂停 |
|
阿勒格尼综合医院 宾夕法尼亚州匹兹堡 15212 |
暂停 |
|
西宾医院 宾夕法尼亚州匹兹堡 15224 |
暂停 |
|
匹兹堡大学癌症研究所（UPCI） 宾夕法尼亚州匹兹堡 15232 |
暂停 |
|
Saint Luke's Hospital-Quakertown Campus Quakertown, Pennsylvania 18951 |
暂停 |
|
Reading Hospital West Reading, Pennsylvania 19611 |
暂停 |
|
Wexford Health and Wellness Pavilion Wexford, Pennsylvania 15090 |
暂停 |
|
Asplundh Cancer Pavilion Willow Grove, Pennsylvania 19090 |
暂停 |
|
AnMed Health Cancer Center Anderson, South Carolina 29621 |
暂停 |
|
Beaufort Memorial Hospital Beaufort, South Carolina 29902 |
暂停 |
|
Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina 29316 |
暂停 |
|
Prisma Health Cancer Institute - Easley Easley, South Carolina 29640 |
暂停 |
|
Saint Francis Hospital Greenville, South Carolina 29601 |
暂停 |
|
Prisma Health Cancer Institute - Butternut 南卡罗来纳州格林维尔 29605 |
暂停 |
|
Prisma Health Cancer Institute - Faris 南卡罗来纳州格林维尔 29605 |
暂停 |
|
Saint Francis Cancer Center Greenville, South Carolina 29607 |
暂停 |
|
Prisma Health Cancer Institute - Eastside 南卡罗来纳州格林维尔 29615 |
暂停 |
|
Prisma Health Cancer Institute - Greer Greer, South Carolina 29650 |
暂停 |
|
Prisma Health Cancer Institute - Seneca Seneca, South Carolina 29672 |
暂停 |
|
Spartanburg Medical Center Spartanburg, South Carolina 29303 |
暂停 |
|
Avera Cancer Institute-Aberdeen Aberdeen, South Dakota 57401 |
暂停 |
|
桑福德癌症中心肿瘤诊所 南达科他州苏福尔斯 57104 |
暂停 |
|
Avera Cancer Institute Sioux Falls, South Dakota 57105 |
暂停 |
|
苏福尔斯桑福德医疗中心 南达科他州苏福尔斯 57117-5134 |
暂停 |
|
Bristol Regional Medical Center Bristol, Tennessee 37620 |
暂停 |
|
Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee 38017 |
暂停 |
|
Cookeville Regional Medical Center Cookeville, Tennessee 38501 |
暂停 |
|
Wellmont Medical Associates Oncology and Hematology-Johnson City Johnson City, Tennessee 37604 |
暂停 |
|
Ballad Health Cancer Care - Kingsport Kingsport, Tennessee 37660 |
暂停 |
|
Wellmont Holston Valley Hospital and Medical Center Kingsport, Tennessee 37660 |
暂停 |
|
孟菲斯浸信会纪念医院和癌症中心 田纳西州孟菲斯 38120 |
暂停 |
|
The Don and Sybil Harrington Cancer Center Amarillo, Texas 79106 |
暂停 |
|
Baptist Hospitals of Southeast Texas Cancer Center Beaumont, Texas 77701 |
暂停 |
|
伍德兰兹的 MD 安德森 德克萨斯州康罗 77384 |
暂停 |
|
Parkland Memorial Hospital Dallas, Texas 75235 |
暂停 |
|
UT Southwestern/Simmons Cancer Center-Dallas 德克萨斯州达拉斯 75390 |
暂停 |
|
STCC at DHR Health Institute for Research and Development Edinburg, Texas 78539 |
暂停 |
|
Lyndon Baines Johnson General Hospital Houston, Texas 77026-1967 |
暂停 |
|
Houston Methodist Hospital 德克萨斯州休斯顿 77030 |
暂停 |
|
安德森癌症中心 德克萨斯州休斯顿 77030 |
暂停 |
|
MD Anderson West Houston Houston, Texas 77079 |
暂停 |
|
MD 安德森联盟城 League City, Texas 77573 |
暂停 |
|
Baptist Regional Cancer Network-Cancer Center of Southeast Texas Port Arthur, Texas 77642 |
暂停 |
|
糖城的 MD 安德森 德克萨斯州糖城 77478 |
暂停 |
|
Scott and White Memorial Hospital Temple, Texas 76508 |
暂停 |
|
亨茨曼癌症研究所/犹他大学 犹他州盐湖城 84112 |
暂停 |
|
Dartmouth Cancer Center - North Saint Johnsbury, Vermont 05819 |
暂停 |
|
Ballad Health Cancer Care - Bristol Bristol, Virginia 24201 |
暂停 |
|
Kaiser Permanente-Burke Medical Center Burke, Virginia 22015 |
暂停 |
|
Augusta Health Center for Cancer and Blood Disorders Fishersville, Virginia 22939 |
暂停 |
|
Centra Alan B Pearson Regional Cancer Center Lynchburg, Virginia 24501 |
暂停 |
|
Kaiser Permanente Tysons Corner Medical Center McLean, Virginia 22102 |
暂停 |
|
Ballad Health Cancer Care - Norton Norton, Virginia 24273 |
暂停 |
|
Virginia Cancer Institute 弗吉尼亚州里士满 23229 |
暂停 |
|
VCU Massey Cancer Center at Stony Point Richmond, Virginia 23235 |
暂停 |
|
弗吉尼亚联邦大学/马西癌症中心 弗吉尼亚州里士满 23298 |
暂停 |
|
VCU Community Memorial Health Center South Hill, Virginia 23970 |
暂停 |
|
Kaiser Permanente-Caton Hill Medical Center Woodbridge, Virginia 22192 |
暂停 |
|
Swedish Cancer Institute-Edmonds Edmonds, Washington 98026 |
暂停 |
|
Swedish Cancer Institute-Issaquah Issaquah, Washington 98029 |
暂停 |
|
Jefferson Healthcare Port Townsend, Washington 98368 |
暂停 |
|
Swedish Medical Center-First Hill Seattle, Washington 98122 |
暂停 |
|
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane, Washington 99204 |
暂停 |
|
MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane, Washington 99218 |
暂停 |
|
West Virginia University Charleston Division Charleston, West Virginia 25304 |
暂停 |
|
West Virginia University Healthcare Morgantown, West Virginia 26506 |
暂停 |
|
Camden Clark Medical Center Parkersburg, West Virginia 26101 |
暂停 |
|
兰拉德医院和癌症中心 威斯康星州安蒂戈 54409 |
暂停 |
|
ThedaCare Regional Cancer Center 威斯康星州阿普尔顿 54911 |
暂停 |
|
Ascension Saint Elizabeth Hospital Appleton, Wisconsin 54915 |
暂停 |
|
Duluth Clinic Ashland Ashland, Wisconsin 54806 |
暂停 |
|
Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin 53045 |
暂停 |
|
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin 54701 |
暂停 |
|
Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin 53132 |
暂停 |
|
Bellin Memorial Hospital Green Bay, Wisconsin 54301 |
暂停 |
|
Mercyhealth Hospital and Cancer Center - Janesville Janesville, Wisconsin 53548 |
暂停 |
|
University of Wisconsin Carbone Cancer Center - Johnson Creek Johnson Creek, Wisconsin 53038 |
暂停 |
|
Gundersen Lutheran Medical Center La Crosse, Wisconsin 54601 |
暂停 |
|
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison, Wisconsin 53718 |
暂停 |
|
University of Wisconsin Carbone Cancer Center - University Hospital 威斯康星州麦迪逊 53792 |
暂停 |
|
Marshfield Medical Center-Marshfield Marshfield, Wisconsin 54449 |
暂停 |
|
Aspirus Medford Hospital Medford, Wisconsin 54451 |
暂停 |
|
Marshfield Medical Center - Minocqua Minocqua, Wisconsin 54548 |
暂停 |
|
ProHealth D N Greenwald Center Mukwonago, Wisconsin 53149 |
暂停 |
|
Cancer Center of Western Wisconsin New Richmond, Wisconsin 54017 |
暂停 |
|
ProHealth Oconomowoc Memorial Hospital Oconomowoc, Wisconsin 53066 |
暂停 |
|
Ascension Mercy Hospital Oshkosh, Wisconsin 54904 |
暂停 |
|
Ascension All Saints Hospital Racine, Wisconsin 53405 |
暂停 |
|
阿斯皮鲁斯癌症护理--詹姆斯-贝克癌症中心 威斯康星州莱茵兰德 54501 |
暂停 |
|
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin 54868 |
暂停 |
|
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin 54482 |
暂停 |
|
ProHealth Waukesha Memorial Hospital Waukesha, Wisconsin 53188 |
暂停 |
|
UW Cancer Center at ProHealth Care Waukesha, Wisconsin 53188 |
暂停 |
|
Aspirus Regional Cancer Center Wausau, Wisconsin 54401 |
暂停 |
|
Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin 53226 |
暂停 |
|
Marshfield Medical Center - Weston Weston, Wisconsin 54476 |
暂停 |
|
威斯康星急流区阿斯皮鲁斯癌症护理中心 威斯康星州威斯康星拉皮兹 54494 |
暂停 |
|
Cheyenne Regional Medical Center-West Cheyenne, Wyoming 82001 |
暂停 |
|
Billings Clinic-Cody Cody, Wyoming 82414 |
暂停 |
纳入标准
纳入标准
* The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
* 年龄 >= 18 岁
* Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
* Diagnosis of metastatic adenocarcinoma of colon or rectum without previous chemotherapy or any other systemic therapy for metastatic colorectal cancer except for one cycle of FOLFOX or capecitabine and oxaliplatin (CAPOX), either with or without bevacizumab prior to enrollment. Upon enrollment, the preceding single cycle of FOLFOX or FOLFOX + bevacizumab, if the patient received one, will not count towards patients' assessments per protocol. Cycle 1 day 1 (C1D1) of atezolizumab or C1D1 of mFOLFOX6/bevacizumab + atezolizumab will correspond to the first day the patient received therapy on trial
* Tumor determined to be mismatch-repair deficient (dMMR) by Clinical Laboratory Improvement Act (CLIA)-certified immunohistochemical (IHC) assay with a panel of all four IHC markers, including MLH1, MSH2, PMS2, and MSH6; alternatively, MSI-H diagnosed by polymerase chain reaction (PCR)-based assessment of microsatellite alterations (either Bethesda markers or Pentaplex panel) or by next-generation sequencing (NGS) are eligible
* Documentation by PET/CT scan, CT scan, or MRI that the patient has measurable metastatic disease per RECIST 1.1
* No immediate need for surgical intervention for the primary tumor or palliative diversion/bypass
* Absolute neutrophil count (ANC) must be >= 1500/mm^3 (obtained within 28 days prior randomization)
* Platelet count must be >= 100,000/mm^3 (obtained within 28 days prior randomization)
* Hemoglobin must be >= 8 g/dL (obtained within 28 days prior randomization)
* Total bilirubin must be =< 4 x ULN (upper limit of normal) (obtained within 28 days prior randomization); and
* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be =< 3 x ULN for the lab with the following exception: for patients with documented liver metastases, AST and ALT must be =< 5 x ULN (obtained within 28 days prior randomization)
* Calculated creatinine clearance >= 30 mL/min (obtained within 28 days prior randomization)
* A urine sample tested for proteinuria by either the dipstick method, urinalysis (UA), or a urine protein creatinine (UPC) ratio:
* The dipstick method must indicate 0-1+ protein; if dipstick reading is >= 2+, a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours or a UPC ratio < 1.0
* A urine protein creatinine (UPC) ratio must be < 1.0; if the UPC ratio is >= 1.0 a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours
* Urinalysis must indicate < 30 mg/dl. If urinalysis >= 30 mg/dl, a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours or a UPC ratio < 1.0
* International normalized ratio of prothrombin time (INR) and prothrombin time (PT) must be =< 1.5 x ULN for the lab within 28 days before randomization; patients who are therapeutically treated with an agent such as warfarin may participate if they are on a stable dose and no underlying abnormality in coagulation parameters exists per medical history, regardless of PT/INR results
* Pregnancy test done within 28 days prior randomization must be negative (for women of childbearing potential only); pregnancy testing should be performed according to institutional standards; administration of atezolizumab or mFOLFOX6/bevacizumab/atezolizumab may have an adverse effect on pregnancy and poses a risk to the human fetus, including embryo-lethality; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
* Women of child-bearing potential and men must agree to use adequate contraception methods that result in a failure rate of < 1% per year during the treatment period (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 5 months (150 days) after the last dose of atezolizumab, 6 months after the last dose of bevacizumab, and 6 months after the last dose of mFOLFOX6; a woman is considered to be of childbearing potential if she is not postmenopausal, has not reached a postmenopausal state (>= 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries and/or uterus); examples of contraceptive methods with a failure rate of < 1% per year include: bilateral tubal ligation; male partner sterilization; intrauterine devices; the reliability of sexual abstinence should be evaluated in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient; periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception; men must refrain from donating sperm during this same period
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* Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies, fluoropyrimidines, folic acid derivatives or oxaliplatin
* Uncontrolled high blood pressure defined as systolic blood pressure (BP) > 150 mmHg or diastolic BP > 100 mmHg with or without anti-hypertensive medication; patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria
* Documented New York Heart Association (NYHA) class III or IV congestive heart failure
* Serious or non-healing wound, skin ulcer, or bone fracture
* History of inherited bleeding diathesis, gastrointestinal (GI) perforation, significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent arterial thrombosis or symptomatic peripheral ischemia, transient ischemic attack [TIA], cerebrovascular accident [CVA] or arterial thrombotic event), abdominal fistula, intra-abdominal abscess, or active GI bleeding (with cause not addressed) within 6 months prior to randomization, or other medical condition in the opinion of the treating oncologist that makes the risk of cardiovascular or bleeding complications with bevacizumab use unacceptably high
* Other malignancies are excluded unless the patient has completed therapy for the malignancy >= 12 months prior to randomization and is considered disease-free; patients with the following cancers are eligible if diagnosed and treated within the past 12 months: in situ carcinomas or basal cell and squamous cell carcinoma of the skin
* Known DPD (dihydro pyrimidine dehydrogenase) deficiency
* Symptomatic peripheral sensory neuropathy >= grade 2 (Common Terminology Criteria for Adverse Events [CTCAE] version [v] 5.0)
* Prior treatment with oxaliplatin chemotherapy within 6 months prior to randomization
* History of grade 2 hemoptysis (defined as 2.5 mL of bright red blood per episode) within 1 month prior to screening
* Prior treatment with anti-PD-1, or anti-PD-L1 therapeutic antibody or pathway-targeting agents; patients who have received prior treatment with anti-CTLA-4 may be enrolled provided the following requirements are met:
* Minimum of 12 weeks from the first dose of anti-CTLA-4 and > 6 weeks from the last dose to randomization
* No history of severe immune-related adverse effects (CTCAE grade 3 and 4) from anti-CTLA-4
* Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF] agents) within 14 days prior to randomization; however,
* Patients who have received acute, low dose, systemic immunosuppressant medications (e.g., a one-time dose of dexamethasone for nausea; or chronic daily treatment with corticosteroids with a dose of =< 10 mg/day methylprednisolone equivalent) may be enrolled
* The use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) for patients with orthostatic hypotension or adrenocortical insufficiency is allowed
* Known clinically significant liver disease, including active viral, alcoholic, or other hepatitis; cirrhosis; fatty liver; and inherited liver disease; however,
* Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen [HbsAg] test and a positive anti-HBc [antibody to hepatitis B core antigen] antibody test) are eligible if polymerase chain reaction (PCR) for hepatits B virus (HBV) ribonucleic acid (RNA) is negative per local guidelines
* Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV RNA per local guidelines
* History or risk of autoimmune disease, including, but not limited to, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis; however,
* Patients with a history of autoimmune hypothyroidism on a stable dose of thyroid replacement hormone may be eligible
* Patients with controlled type 1 diabetes mellitus on a stable insulin regimen may be eligible
* Patients with eczema, psoriasis, lichen simplex chronicus or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis would be excluded) are permitted provided that they meet the following conditions:
* Patients with psoriasis must have a baseline ophthalmologic exam to rule out ocular manifestations
* Rash must cover less than 10% of body surface area (BSA)
* Disease is well controlled at baseline and only requiring low potency topical steroids (e.g., hydrocortisone 2.5%, hydrocortisone butyrate 0.1%, fluocinolone 0.01%, desonide 0.05%, alclometasone dipropionate 0.05%)
* No acute exacerbations of underlying condition within the last 12 months (not requiring psoralen plus ultraviolet A radiation [PUVA], methotrexate, retinoids, biologic agents, oral calcineurin inhibitors; high potency or oral steroids)
* History of idiopathic pulmonary fibrosis, organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or active or recently active (within 90 days of randomization) pneumonitis (including drug induced) that required systemic immunosuppressive therapy (i.e. corticosteroids, etc.). History of radiation pneumonitis in the radiation field (fibrosis) is permitted
* History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
* Patients with known active tuberculosis (TB) are excluded
* Severe infections within 28 days prior to randomization, including but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia
* Signs or symptoms of infection within 14 days prior to randomization
* Received oral or intravenous (IV) antibiotics within 14 days prior to randomization; patients receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are eligible
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to randomization or anticipation of need for a major surgical procedure during the course of the study
* The administration of a live, attenuated vaccine within 28 days prior to randomization
* Pregnant women are excluded from this study because atezolizumab is an agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with atezolizumab, breastfeeding should be discontinued if the mother is treated with atezolizumab; these potential risks may also apply to other agents used in this study; (Note: pregnancy testing should be performed within 28 days prior to randomization according to institutional standards for women of childbearing potential)
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
* Patients with prior allogeneic bone marrow transplantation or prior solid organ transplantation
