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Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer, the COMMIT Study

Program Status

Active, not recruiting

Phase

Phase 3

Prior Immunotherapy Allowed

CRC-directed Trial

Yes

Drugs

Atezolizumab, fluorouracil, Leucovorin, oxaliplatin

Tags

MSI-H/ MMRd

Location	Location Status
United States
Kingman Regional Medical Center Kingman, Arizona 86401	Active, not recruiting
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro, Arkansas 72401	Active, not recruiting
Kaiser Permanente-Anaheim Anaheim, California 92806	Active, not recruiting
Kaiser Permanente-Baldwin Park Baldwin Park, California 91706	Active, not recruiting
Kaiser Permanente-Bellflower Bellflower, California 90706	Active, not recruiting
Alta Bates Summit Medical Center-Herrick Campus Berkeley, California 94704	Active, not recruiting
John Muir Medical Center-Concord Concord, California 94520	Active, not recruiting
Kaiser Permanente-Fontana Fontana, California 92335	Active, not recruiting
Kaiser Permanente South Bay Harbor City, California 90710	Active, not recruiting
Kaiser Permanente-Irvine Irvine, California 92618	Active, not recruiting
Kaiser Permanente Los Angeles Medical Center Los Angeles, California 90027	Active, not recruiting
Kaiser Permanente West Los Angeles Los Angeles, California 90034	Active, not recruiting
Fremont - Rideout Cancer Center Marysville, California 95901	Active, not recruiting
Memorial Medical Center Modesto, California 95355	Active, not recruiting
Kaiser Permanente-Ontario Ontario, California 91761	Active, not recruiting
Saint Joseph Hospital - Orange Orange, California 92868	Active, not recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange, California 92868	Active, not recruiting
Kaiser Permanente - Panorama City Panorama City, California 91402	Active, not recruiting
Kaiser Permanente-Riverside Riverside, California 92505	Active, not recruiting
Sutter Medical Center Sacramento Sacramento, California 95816	Active, not recruiting
University of California Davis Comprehensive Cancer Center Sacramento, California 95817	Active, not recruiting
Salinas Valley Memorial Salinas, California 93901	Active, not recruiting
Kaiser Permanente-San Diego Mission San Diego, California 92108	Active, not recruiting
Kaiser Permanente-San Diego Zion San Diego, California 92120	Active, not recruiting
Kaiser Permanente-San Marcos San Marcos, California 92078	Active, not recruiting
John Muir Medical Center-Walnut Creek Walnut Creek, California 94598	Active, not recruiting
Presbyterian Intercommunity Hospital Whittier, California 90602	Active, not recruiting
Kaiser Permanente-Woodland Hills Woodland Hills, California 91367	Active, not recruiting
Rocky Mountain Cancer Centers-Aurora Aurora, Colorado 80012	Active, not recruiting
UCHealth University of Colorado Hospital Aurora, Colorado 80045	Active, not recruiting
Boulder Community Foothills Hospital Boulder, Colorado 80303	Active, not recruiting
Rocky Mountain Cancer Centers-Boulder Boulder, Colorado 80304	Active, not recruiting
Penrose-Saint Francis Healthcare Colorado Springs, Colorado 80907	Active, not recruiting
UCHealth Memorial Hospital Central Colorado Springs, Colorado 80909	Active, not recruiting
Memorial Hospital North Colorado Springs, Colorado 80920	Active, not recruiting
Denver Health Medical Center Denver, Colorado 80204	Active, not recruiting
National Jewish Health-Main Campus Denver, Colorado 80206	Active, not recruiting
AdventHealth Porter Denver, Colorado 80210	Active, not recruiting
Rocky Mountain Cancer Centers-Midtown Denver, Colorado 80218	Active, not recruiting
Saint Joseph Hospital - Cancer Centers of Colorado Denver, Colorado 80218	Active, not recruiting
Rocky Mountain Cancer Centers-Rose Denver, Colorado 80220	Active, not recruiting
Mountain Blue Cancer Care Center - Swedish Englewood, Colorado 80113	Active, not recruiting
Swedish Medical Center Englewood, Colorado 80113	Active, not recruiting
Poudre Valley Hospital Fort Collins, Colorado 80524	Active, not recruiting
Cancer Care and Hematology-Fort Collins Fort Collins, Colorado 80528	Active, not recruiting
National Jewish Health-Western Hematology Oncology Golden, Colorado 80401	Active, not recruiting
Banner North Colorado Medical Center Greeley, Colorado 80631	Active, not recruiting
UCHealth Greeley Hospital Greeley, Colorado 80631	Active, not recruiting
Rocky Mountain Cancer Centers-Littleton Littleton, Colorado 80120	Active, not recruiting
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree, Colorado 80124	Active, not recruiting
Medical Center of the Rockies Loveland, Colorado 80538	Active, not recruiting
Banner McKee Medical Center Loveland, Colorado 80539	Active, not recruiting
National Jewish Health-Northern Hematology Oncology Thornton, Colorado 80260	Active, not recruiting
Intermountain Health Lutheran Hospital Wheat Ridge, Colorado 80401	Active, not recruiting
Danbury Hospital Danbury, Connecticut 06810	Active, not recruiting
Hartford Hospital Hartford, Connecticut 06102	Active, not recruiting
Midstate Medical Center Meriden, Connecticut 06451	Active, not recruiting
The Hospital of Central Connecticut New Britain, Connecticut 06050	Active, not recruiting
William Backus Hospital Norwich, Connecticut 06360	Active, not recruiting
Beebe South Coastal Health Campus Millville, Delaware 19967	Active, not recruiting
Helen F Graham Cancer Center Newark, Delaware 19713	Active, not recruiting
Medical Oncology Hematology Consultants PA Newark, Delaware 19713	Active, not recruiting
Beebe Health Campus Rehoboth Beach, Delaware 19971	Active, not recruiting
Kaiser Permanente-Capitol Hill Medical Center Washington D.C., District of Columbia 20002	Active, not recruiting
Broward Health Medical Center Fort Lauderdale, Florida 33316	Active, not recruiting
Regional Cancer Center-Lee Memorial Health System Fort Myers, Florida 33905	Active, not recruiting
University of Florida Health Science Center - Gainesville Gainesville, Florida 32610	Active, not recruiting
Baptist MD Anderson Cancer Center Jacksonville, Florida 32207	Active, not recruiting
AdventHealth Orlando Orlando, Florida 32803	Active, not recruiting
Phoebe Putney Memorial Hospital Albany, Georgia 31701	Active, not recruiting
University Cancer and Blood Center LLC Athens, Georgia 30607	Active, not recruiting
Augusta Oncology Associates PC-D'Antignac Augusta, Georgia 30901	Active, not recruiting
Augusta Oncology Associates PC-Wheeler Augusta, Georgia 30909	Active, not recruiting
Augusta University Medical Center Augusta, Georgia 30912	Active, not recruiting
CTCA at Southeastern Regional Medical Center Newnan, Georgia 30265	Active, not recruiting
Saint Alphonsus Cancer Care Center-Boise Boise, Idaho 83706	Active, not recruiting
Saint Luke's Cancer Institute - Boise Boise, Idaho 83712	Active, not recruiting
Saint Alphonsus Cancer Care Center-Caldwell Caldwell, Idaho 83605	Active, not recruiting
Kootenai Health - Coeur d'Alene Coeur d'Alene, Idaho 83814	Active, not recruiting
Saint Luke's Cancer Institute - Fruitland Fruitland, Idaho 83619	Active, not recruiting
Saint Luke's Cancer Institute - Meridian Meridian, Idaho 83642	Active, not recruiting
Saint Alphonsus Cancer Care Center-Nampa Nampa, Idaho 83687	Active, not recruiting
Saint Luke's Cancer Institute - Nampa Nampa, Idaho 83687	Active, not recruiting
Kootenai Clinic Cancer Services - Post Falls Post Falls, Idaho 83854	Active, not recruiting
Kootenai Clinic Cancer Services - Sandpoint Sandpoint, Idaho 83864	Active, not recruiting
Saint Luke's Cancer Institute - Twin Falls Twin Falls, Idaho 83301	Active, not recruiting
Illinois CancerCare-Bloomington Bloomington, Illinois 61704	Active, not recruiting
Illinois CancerCare-Canton Canton, Illinois 61520	Active, not recruiting
Illinois CancerCare-Carthage Carthage, Illinois 62321	Active, not recruiting
Centralia Oncology Clinic Centralia, Illinois 62801	Active, not recruiting
Rush University Medical Center Chicago, Illinois 60612	Active, not recruiting
University of Illinois Chicago, Illinois 60612	Active, not recruiting
Carle at The Riverfront Danville, Illinois 61832	Active, not recruiting
Cancer Care Specialists of Illinois - Decatur Decatur, Illinois 62526	Active, not recruiting
Illinois CancerCare-Dixon Dixon, Illinois 61021	Active, not recruiting
Carle Physician Group-Effingham Effingham, Illinois 62401	Active, not recruiting
Crossroads Cancer Center Effingham, Illinois 62401	Active, not recruiting
Illinois CancerCare-Eureka Eureka, Illinois 61530	Active, not recruiting
NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois 60201	Active, not recruiting
Illinois CancerCare-Galesburg Galesburg, Illinois 61401	Active, not recruiting
NorthShore University HealthSystem-Glenbrook Hospital Glenview, Illinois 60026	Active, not recruiting
NorthShore University HealthSystem-Highland Park Hospital Highland Park, Illinois 60035	Active, not recruiting
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois 61443	Active, not recruiting
Illinois CancerCare-Macomb Macomb, Illinois 61455	Active, not recruiting
Carle Physician Group-Mattoon/Charleston Mattoon, Illinois 61938	Active, not recruiting
Loyola University Medical Center Maywood, Illinois 60153	Active, not recruiting
SSM Health Good Samaritan Mount Vernon, Illinois 62864	Active, not recruiting
Cancer Care Center of O'Fallon O'Fallon, Illinois 62269	Active, not recruiting
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois 61350	Active, not recruiting
Illinois CancerCare-Pekin Pekin, Illinois 61554	Active, not recruiting
Illinois CancerCare-Peoria Peoria, Illinois 61615	Active, not recruiting
Illinois CancerCare-Peru Peru, Illinois 61354	Active, not recruiting
Illinois CancerCare-Princeton Princeton, Illinois 61356	Active, not recruiting
Southern Illinois University School of Medicine Springfield, Illinois 62702	Active, not recruiting
Springfield Clinic Springfield, Illinois 62702	Active, not recruiting
Carle Cancer Center Urbana, Illinois 61801	Active, not recruiting
Illinois CancerCare - Washington Washington, Illinois 61571	Active, not recruiting
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana 46202	Active, not recruiting
Community Cancer Center East Indianapolis, Indiana 46219	Active, not recruiting
Community Cancer Center South Indianapolis, Indiana 46227	Active, not recruiting
Franciscan Health Indianapolis Indianapolis, Indiana 46237	Active, not recruiting
Community Cancer Center North Indianapolis, Indiana 46256	Active, not recruiting
Community Howard Regional Health Kokomo, Indiana 46904	Active, not recruiting
Franciscan Saint Elizabeth Health - Lafayette East Lafayette, Indiana 47905	Active, not recruiting
Woodland Cancer Care Center Michigan City, Indiana 46360	Active, not recruiting
Franciscan Health Mooresville Mooresville, Indiana 46158	Active, not recruiting
Union Hospital Terre Haute, Indiana 47804	Active, not recruiting
Mary Greeley Medical Center Ames, Iowa 50010	Active, not recruiting
McFarland Clinic - Ames Ames, Iowa 50010	Active, not recruiting
University of Iowa Healthcare Cancer Services Quad Cities Bettendorf, Iowa 52722	Active, not recruiting
McFarland Clinic - Boone Boone, Iowa 50036	Active, not recruiting
Mercy Hospital Cedar Rapids, Iowa 52403	Active, not recruiting
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa 52403	Active, not recruiting
Mercy Cancer Center-West Lakes Clive, Iowa 50325	Active, not recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive, Iowa 50325	Active, not recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines, Iowa 50309	Active, not recruiting
Broadlawns Medical Center Des Moines, Iowa 50314	Active, not recruiting
Mercy Medical Center - Des Moines Des Moines, Iowa 50314	Active, not recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines, Iowa 50314	Active, not recruiting
McFarland Clinic - Trinity Cancer Center Fort Dodge, Iowa 50501	Active, not recruiting
UI Healthcare Mission Cancer and Blood - Fort Dodge Fort Dodge, Iowa 50501	Active, not recruiting
University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa 52242	Active, not recruiting
McFarland Clinic - Jefferson Jefferson, Iowa 50129	Active, not recruiting
McFarland Clinic - Marshalltown Marshalltown, Iowa 50158	Active, not recruiting
Mercy Medical Center-West Lakes West Des Moines, Iowa 50266	Active, not recruiting
HaysMed Hays, Kansas 67601	Active, not recruiting
Lawrence Memorial Hospital Lawrence, Kansas 66044	Active, not recruiting
The University of Kansas Cancer Center - Olathe Olathe, Kansas 66061	Active, not recruiting
Salina Regional Health Center Salina, Kansas 67401	Active, not recruiting
University of Kansas Health System Saint Francis Campus Topeka, Kansas 66606	Active, not recruiting
University of Kansas Hospital-Westwood Cancer Center Westwood, Kansas 66205	Active, not recruiting
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas 67208	Active, not recruiting
Cancer Center of Kansas - Wichita Wichita, Kansas 67214	Active, not recruiting
Flaget Memorial Hospital Bardstown, Kentucky 40004	Active, not recruiting
Baptist Health Lexington Lexington, Kentucky 40503	Active, not recruiting
Saint Joseph Hospital East Lexington, Kentucky 40509	Active, not recruiting
University of Kentucky/Markey Cancer Center Lexington, Kentucky 40536	Active, not recruiting
Norton Hospital Pavilion and Medical Campus Louisville, Kentucky 40202	Active, not recruiting
Norton Audubon Hospital and Medical Campus Louisville, Kentucky 40217	Active, not recruiting
Norton Brownsboro Hospital and Medical Campus Louisville, Kentucky 40241	Active, not recruiting
Ochsner Medical Center Kenner Kenner, Louisiana 70065	Active, not recruiting
Ochsner Medical Center Jefferson New Orleans, Louisiana 70121	Active, not recruiting
Harold Alfond Center for Cancer Care Augusta, Maine 04330	Active, not recruiting
Eastern Maine Medical Center Bangor, Maine 04401	Active, not recruiting
MaineHealth Waldo Hospital Belfast, Maine 04915	Active, not recruiting
MaineHealth Maine Medical Center - Biddeford Biddeford, Maine 04005	Active, not recruiting
Lafayette Family Cancer Center-EMMC Brewer, Maine 04412	Active, not recruiting
Penobscot Bay Medical Center Rockport, Maine 04856	Active, not recruiting
MaineHealth Cancer Care and IV Therapy - Sanford Sanford, Maine 04073	Active, not recruiting
MaineHealth Cancer Care and IV Therapy - South Portland South Portland, Maine 04106	Active, not recruiting
Kaiser Permanente-Woodlawn Medical Center Baltimore, Maryland 21244	Active, not recruiting
University of Maryland Shore Medical Center at Easton Easton, Maryland 21601	Active, not recruiting
Kaiser Permanente-Gaithersburg Medical Center Gaithersburg, Maryland 20879	Active, not recruiting
Kaiser Permanente - Largo Medical Center Largo, Maryland 20774	Active, not recruiting
Kaiser Permanente Lutherville - Timonium Medical Center Lutherville, Maryland 21093	Active, not recruiting
Dana-Farber Cancer Institute Boston, Massachusetts 02215	Active, not recruiting
Lowell General Hospital Lowell, Massachusetts 01854	Active, not recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor, Michigan 48106	Active, not recruiting
McLaren Cancer Institute-Bay City Bay City, Michigan 48706	Active, not recruiting
McLaren Cancer Institute-Bloomfield Bloomfield, Michigan 48302	Active, not recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton, Michigan 48114	Active, not recruiting
Trinity Health Medical Center - Brighton Brighton, Michigan 48114	Active, not recruiting
Henry Ford Cancer Institute-Downriver Brownstown, Michigan 48183	Active, not recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton, Michigan 48188	Active, not recruiting
Trinity Health Medical Center - Canton Canton, Michigan 48188	Active, not recruiting
Chelsea Hospital Chelsea, Michigan 48118	Active, not recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea, Michigan 48118	Active, not recruiting
Hematology Oncology Consultants-Clarkston Clarkston, Michigan 48346	Active, not recruiting
McLaren Cancer Institute-Clarkston Clarkston, Michigan 48346	Active, not recruiting
Newland Medical Associates-Clarkston Clarkston, Michigan 48346	Active, not recruiting
Henry Ford Macomb Hospital-Clinton Township Clinton Township, Michigan 48038	Active, not recruiting
Henry Ford Medical Center-Fairlane Dearborn, Michigan 48126	Active, not recruiting
Wayne State University/Karmanos Cancer Institute Detroit, Michigan 48201	Active, not recruiting
Henry Ford Hospital Detroit, Michigan 48202	Active, not recruiting
Weisberg Cancer Treatment Center Farmington Hills, Michigan 48334	Active, not recruiting
McLaren Cancer Institute-Flint Flint, Michigan 48532	Active, not recruiting
Singh and Arora Hematology Oncology PC Flint, Michigan 48532	Active, not recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids, Michigan 49503	Active, not recruiting
Allegiance Health Jackson, Michigan 49201	Active, not recruiting
West Michigan Cancer Center Kalamazoo, Michigan 49007	Active, not recruiting
Karmanos Cancer Institute at McLaren Greater Lansing Lansing, Michigan 48910	Active, not recruiting
University of Michigan Health - Sparrow Lansing Lansing, Michigan 48912	Active, not recruiting
McLaren Cancer Institute-Lapeer Region Lapeer, Michigan 48446	Active, not recruiting
Hope Cancer Clinic Livonia, Michigan 48154	Active, not recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia, Michigan 48154	Active, not recruiting
McLaren Cancer Institute-Macomb Mount Clemens, Michigan 48043	Active, not recruiting
McLaren Cancer Institute-Central Michigan Mount Pleasant, Michigan 48858	Active, not recruiting
Henry Ford Medical Center-Columbus Novi, Michigan 48377	Active, not recruiting
McLaren Cancer Institute-Northern Michigan Petoskey, Michigan 49770	Active, not recruiting
Newland Medical Associates-Pontiac Pontiac, Michigan 48341	Active, not recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac, Michigan 48341	Active, not recruiting
McLaren-Port Huron Port Huron, Michigan 48060	Active, not recruiting
MyMichigan Medical Center Saginaw Saginaw, Michigan 48601	Active, not recruiting
Oncology Hematology Associates of Saginaw Valley PC Saginaw, Michigan 48604	Active, not recruiting
MyMichigan Medical Center Tawas Tawas City, Michigan 48764	Active, not recruiting
Munson Medical Center Traverse City, Michigan 49684	Active, not recruiting
Henry Ford West Bloomfield Hospital West Bloomfield, Michigan 48322	Active, not recruiting
Saint Mary's Oncology/Hematology Associates of West Branch West Branch, Michigan 48661	Active, not recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti, Michigan 48197	Active, not recruiting
Sanford Joe Lueken Cancer Center Bemidji, Minnesota 56601	Active, not recruiting
Minnesota Oncology - Burnsville Burnsville, Minnesota 55337	Active, not recruiting
Essentia Health - Deer River Clinic Deer River, Minnesota 56636	Active, not recruiting
Essentia Health Cancer Center Duluth, Minnesota 55805	Active, not recruiting
Essentia Health Hibbing Clinic Hibbing, Minnesota 55746	Active, not recruiting
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota 55109	Active, not recruiting
Saint John's Hospital - Healtheast Maplewood, Minnesota 55109	Active, not recruiting
Hennepin County Medical Center Minneapolis, Minnesota 55415	Active, not recruiting
Health Partners Inc Minneapolis, Minnesota 55454	Active, not recruiting
Regions Hospital Saint Paul, Minnesota 55101	Active, not recruiting
United Hospital Saint Paul, Minnesota 55102	Active, not recruiting
Essentia Health Sandstone Sandstone, Minnesota 55072	Active, not recruiting
Essentia Health Virginia Clinic Virginia, Minnesota 55792	Active, not recruiting
Baptist Cancer Center-Grenada Grenada, Mississippi 38901	Active, not recruiting
Baptist Memorial Hospital and Cancer Center-Union County New Albany, Mississippi 38652	Active, not recruiting
Baptist Memorial Hospital and Cancer Center-Oxford Oxford, Mississippi 38655	Active, not recruiting
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven, Mississippi 38671	Active, not recruiting
Mercy Oncology and Hematology - Clayton-Clarkson Ballwin, Missouri 63011	Active, not recruiting
Saint Francis Medical Center Cape Girardeau, Missouri 63703	Active, not recruiting
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia, Missouri 65212	Active, not recruiting
Freeman Health System Joplin, Missouri 64804	Active, not recruiting
Mercy Hospital Joplin Joplin, Missouri 64804	Active, not recruiting
University Health Truman Medical Center Kansas City, Missouri 64108	Active, not recruiting
Mercy Infusion Center - Chippewa St Louis, Missouri 63109	Active, not recruiting
Mercy Hospital Saint Louis St Louis, Missouri 63141	Active, not recruiting
Community Hospital of Anaconda Anaconda, Montana 59711	Active, not recruiting
Billings Clinic Cancer Center Billings, Montana 59101	Active, not recruiting
Bozeman Health Deaconess Hospital Bozeman, Montana 59715	Active, not recruiting
Benefis Sletten Cancer Institute Great Falls, Montana 59405	Active, not recruiting
Great Falls Clinic Great Falls, Montana 59405	Active, not recruiting
Saint Peter's Community Hospital Helena, Montana 59601	Active, not recruiting
Logan Health Medical Center Kalispell, Montana 59901	Active, not recruiting
Community Medical Center Missoula, Montana 59804	Active, not recruiting
Nebraska Methodist Hospital Omaha, Nebraska 68114	Active, not recruiting
OptumCare Cancer Care at Seven Hills Henderson, Nevada 89052	Active, not recruiting
OptumCare Cancer Care at Charleston Las Vegas, Nevada 89102	Active, not recruiting
OptumCare Cancer Care at MountainView Las Vegas, Nevada 89128	Active, not recruiting
OptumCare Cancer Care at Fort Apache Las Vegas, Nevada 89148	Active, not recruiting
Renown Regional Medical Center Reno, Nevada 89502	Active, not recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon, New Hampshire 03756	Active, not recruiting
Dartmouth Cancer Center - Manchester Manchester, New Hampshire 03102	Active, not recruiting
Dartmouth Cancer Center - Nashua Nashua, New Hampshire 03063	Active, not recruiting
The Cancer Institute of New Jersey Hamilton Hamilton, New Jersey 08690	Active, not recruiting
Morristown Medical Center Morristown, New Jersey 07960	Active, not recruiting
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey 08903	Active, not recruiting
The Valley Hospital - Luckow Pavilion Paramus, New Jersey 07652	Active, not recruiting
Valley Health System Ridgewood Campus Ridgewood, New Jersey 07450	Active, not recruiting
Robert Wood Johnson University Hospital Somerset Somerville, New Jersey 08876	Active, not recruiting
Overlook Hospital Summit, New Jersey 07902	Active, not recruiting
University of New Mexico Cancer Center Albuquerque, New Mexico 87106	Active, not recruiting
Presbyterian Kaseman Hospital Albuquerque, New Mexico 87110	Active, not recruiting
Memorial Medical Center-Las Cruces Las Cruces, New Mexico 88011	Active, not recruiting
Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho, New Mexico 87124	Active, not recruiting
Roswell Park Cancer Institute Buffalo, New York 14263	Active, not recruiting
Arnot Ogden Medical Center/Falck Cancer Center Elmira, New York 14905	Active, not recruiting
Northwell Health/Center for Advanced Medicine Lake Success, New York 11042	Active, not recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York 10016	Active, not recruiting
University of Rochester Rochester, New York 14642	Active, not recruiting
Dickstein Cancer Treatment Center White Plains, New York 10601	Active, not recruiting
UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina 27599	Active, not recruiting
Southeastern Medical Oncology Center-Clinton Clinton, North Carolina 28328	Active, not recruiting
Southeastern Medical Oncology Center-Goldsboro Goldsboro, North Carolina 27534	Active, not recruiting
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina 28791	Active, not recruiting
Southeastern Medical Oncology Center-Jacksonville Jacksonville, North Carolina 28546	Active, not recruiting
ECU Health Oncology Kenansville Kenansville, North Carolina 28349	Active, not recruiting
ECU Health Oncology Kinston Kinston, North Carolina 28501	Active, not recruiting
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst, North Carolina 28374	Active, not recruiting
ECU Health Oncology Richlands Richlands, North Carolina 28574	Active, not recruiting
Wake Forest University Health Sciences Winston-Salem, North Carolina 27157	Active, not recruiting
Sanford Bismarck Medical Center Bismarck, North Dakota 58501	Active, not recruiting
Sanford Broadway Medical Center Fargo, North Dakota 58122	Active, not recruiting
Sanford Roger Maris Cancer Center Fargo, North Dakota 58122	Active, not recruiting
Altru Cancer Center Grand Forks, North Dakota 58201	Active, not recruiting
Cleveland Clinic Akron General Akron, Ohio 44307	Active, not recruiting
Strecker Cancer Center-Belpre Belpre, Ohio 45714	Active, not recruiting
Dayton Physicians LLC-Miami Valley South Centerville, Ohio 45459	Active, not recruiting
Miami Valley Hospital South Centerville, Ohio 45459	Active, not recruiting
Adena Regional Medical Center Chillicothe, Ohio 45601	Active, not recruiting
University of Cincinnati Cancer Center-UC Medical Center Cincinnati, Ohio 45219	Active, not recruiting
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland, Ohio 44111	Active, not recruiting
Ohio State University Comprehensive Cancer Center Columbus, Ohio 43210	Active, not recruiting
Mount Carmel East Hospital Columbus, Ohio 43213	Active, not recruiting
Columbus Oncology and Hematology Associates Inc Columbus, Ohio 43214	Active, not recruiting
Riverside Methodist Hospital Columbus, Ohio 43214	Active, not recruiting
Grant Medical Center Columbus, Ohio 43215	Active, not recruiting
The Mark H Zangmeister Center Columbus, Ohio 43219	Active, not recruiting
Mount Carmel Health Center West Columbus, Ohio 43222	Active, not recruiting
Doctors Hospital Columbus, Ohio 43228	Active, not recruiting
Miami Valley Hospital Dayton, Ohio 45409	Active, not recruiting
Delaware Health Center-Grady Cancer Center Delaware, Ohio 43015	Active, not recruiting
Grady Memorial Hospital Delaware, Ohio 43015	Active, not recruiting
Greater Dayton Cancer Center Kettering, Ohio 45409	Active, not recruiting
Fairfield Medical Center Lancaster, Ohio 43130	Active, not recruiting
OhioHealth Mansfield Hospital Mansfield, Ohio 44903	Active, not recruiting
Cleveland Clinic Cancer Center Mansfield Mansfield, Ohio 44906	Active, not recruiting
Marietta Memorial Hospital Marietta, Ohio 45750	Active, not recruiting
OhioHealth Marion General Hospital Marion, Ohio 43302	Active, not recruiting
Hillcrest Hospital Cancer Center Mayfield Heights, Ohio 44124	Active, not recruiting
Knox Community Hospital Mount Vernon, Ohio 43050	Active, not recruiting
Licking Memorial Hospital Newark, Ohio 43055	Active, not recruiting
Southern Ohio Medical Center Portsmouth, Ohio 45662	Active, not recruiting
North Coast Cancer Care Sandusky, Ohio 44870	Active, not recruiting
ProMedica Flower Hospital Sylvania, Ohio 43560	Active, not recruiting
South Pointe Hospital Warrensville Heights, Ohio 44122	Active, not recruiting
University of Cincinnati Cancer Center-West Chester West Chester, Ohio 45069	Active, not recruiting
Saint Ann's Hospital Westerville, Ohio 43081	Active, not recruiting
Genesis Healthcare System Cancer Care Center Zanesville, Ohio 43701	Active, not recruiting
Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma 73505	Active, not recruiting
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma 73104	Active, not recruiting
Cancer Treatment Centers of America Tulsa, Oklahoma 74133	Active, not recruiting
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa, Oklahoma 74146	Active, not recruiting
Saint Charles Health System Bend, Oregon 97701	Active, not recruiting
Clackamas Radiation Oncology Center Clackamas, Oregon 97015	Active, not recruiting
Providence Cancer Institute Clackamas Clinic Clackamas, Oregon 97015	Active, not recruiting
Providence Newberg Medical Center Newberg, Oregon 97132	Active, not recruiting
Saint Alphonsus Cancer Care Center-Ontario Ontario, Oregon 97914	Active, not recruiting
Providence Willamette Falls Medical Center Oregon City, Oregon 97045	Active, not recruiting
Providence Portland Medical Center Portland, Oregon 97213	Active, not recruiting
Providence Saint Vincent Medical Center Portland, Oregon 97225	Active, not recruiting
Lehigh Valley Hospital-Cedar Crest Allentown, Pennsylvania 18103	Active, not recruiting
Saint Luke's Cancer Center - Allentown Allentown, Pennsylvania 18104	Active, not recruiting
Saint Luke's University Hospital-Bethlehem Campus Bethlehem, Pennsylvania 18015	Active, not recruiting
Lehigh Valley Hospital - Muhlenberg Bethlehem, Pennsylvania 18017	Active, not recruiting
Saint Luke's Hospital-Anderson Campus Easton, Pennsylvania 18045	Active, not recruiting
Saint Vincent Hospital Erie, Pennsylvania 16544	Active, not recruiting
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg, Pennsylvania 17109	Active, not recruiting
Jefferson Hospital Jefferson Hills, Pennsylvania 15025	Active, not recruiting
Forbes Hospital Monroeville, Pennsylvania 15146	Active, not recruiting
Allegheny Valley Hospital Natrona Heights, Pennsylvania 15065	Active, not recruiting
Allegheny General Hospital Pittsburgh, Pennsylvania 15212	Active, not recruiting
West Penn Hospital Pittsburgh, Pennsylvania 15224	Active, not recruiting
University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania 15232	Active, not recruiting
Saint Luke's Hospital-Quakertown Campus Quakertown, Pennsylvania 18951	Active, not recruiting
Reading Hospital West Reading, Pennsylvania 19611	Active, not recruiting
Wexford Health and Wellness Pavilion Wexford, Pennsylvania 15090	Active, not recruiting
Asplundh Cancer Pavilion Willow Grove, Pennsylvania 19090	Active, not recruiting
AnMed Health Cancer Center Anderson, South Carolina 29621	Active, not recruiting
Beaufort Memorial Hospital Beaufort, South Carolina 29902	Active, not recruiting
Prisma Health Cancer Institute - Spartanburg Boiling Springs, South Carolina 29316	Active, not recruiting
Prisma Health Cancer Institute - Easley Easley, South Carolina 29640	Active, not recruiting
Saint Francis Hospital Greenville, South Carolina 29601	Active, not recruiting
Prisma Health Cancer Institute - Butternut Greenville, South Carolina 29605	Active, not recruiting
Prisma Health Cancer Institute - Faris Greenville, South Carolina 29605	Active, not recruiting
Saint Francis Cancer Center Greenville, South Carolina 29607	Active, not recruiting
Prisma Health Cancer Institute - Eastside Greenville, South Carolina 29615	Active, not recruiting
Prisma Health Cancer Institute - Greer Greer, South Carolina 29650	Active, not recruiting
Prisma Health Cancer Institute - Seneca Seneca, South Carolina 29672	Active, not recruiting
Spartanburg Medical Center Spartanburg, South Carolina 29303	Active, not recruiting
Avera Cancer Institute-Aberdeen Aberdeen, South Dakota 57401	Active, not recruiting
Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota 57104	Active, not recruiting
Avera Cancer Institute Sioux Falls, South Dakota 57105	Active, not recruiting
Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota 57117-5134	Active, not recruiting
Bristol Regional Medical Center Bristol, Tennessee 37620	Active, not recruiting
Baptist Memorial Hospital and Cancer Center-Collierville Collierville, Tennessee 38017	Active, not recruiting
Cookeville Regional Medical Center Cookeville, Tennessee 38501	Active, not recruiting
Wellmont Medical Associates Oncology and Hematology-Johnson City Johnson City, Tennessee 37604	Active, not recruiting
Ballad Health Cancer Care - Kingsport Kingsport, Tennessee 37660	Active, not recruiting
Wellmont Holston Valley Hospital and Medical Center Kingsport, Tennessee 37660	Active, not recruiting
Baptist Memorial Hospital and Cancer Center-Memphis Memphis, Tennessee 38120	Active, not recruiting
The Don and Sybil Harrington Cancer Center Amarillo, Texas 79106	Active, not recruiting
Baptist Hospitals of Southeast Texas Cancer Center Beaumont, Texas 77701	Active, not recruiting
MD Anderson in The Woodlands Conroe, Texas 77384	Active, not recruiting
Parkland Memorial Hospital Dallas, Texas 75235	Active, not recruiting
UT Southwestern/Simmons Cancer Center-Dallas Dallas, Texas 75390	Active, not recruiting
STCC at DHR Health Institute for Research and Development Edinburg, Texas 78539	Active, not recruiting
Lyndon Baines Johnson General Hospital Houston, Texas 77026-1967	Active, not recruiting
Houston Methodist Hospital Houston, Texas 77030	Active, not recruiting
M D Anderson Cancer Center Houston, Texas 77030	Active, not recruiting
MD Anderson West Houston Houston, Texas 77079	Active, not recruiting
MD Anderson League City League City, Texas 77573	Active, not recruiting
Baptist Regional Cancer Network-Cancer Center of Southeast Texas Port Arthur, Texas 77642	Active, not recruiting
MD Anderson in Sugar Land Sugar Land, Texas 77478	Active, not recruiting
Scott and White Memorial Hospital Temple, Texas 76508	Active, not recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City, Utah 84112	Active, not recruiting
Dartmouth Cancer Center - North Saint Johnsbury, Vermont 05819	Active, not recruiting
Ballad Health Cancer Care - Bristol Bristol, Virginia 24201	Active, not recruiting
Kaiser Permanente-Burke Medical Center Burke, Virginia 22015	Active, not recruiting
Augusta Health Center for Cancer and Blood Disorders Fishersville, Virginia 22939	Active, not recruiting
Centra Alan B Pearson Regional Cancer Center Lynchburg, Virginia 24501	Active, not recruiting
Kaiser Permanente Tysons Corner Medical Center McLean, Virginia 22102	Active, not recruiting
Ballad Health Cancer Care - Norton Norton, Virginia 24273	Active, not recruiting
Virginia Cancer Institute Richmond, Virginia 23229	Active, not recruiting
VCU Massey Cancer Center at Stony Point Richmond, Virginia 23235	Active, not recruiting
VCU Massey Comprehensive Cancer Center Richmond, Virginia 23298	Active, not recruiting
VCU Community Memorial Health Center South Hill, Virginia 23970	Active, not recruiting
Kaiser Permanente-Caton Hill Medical Center Woodbridge, Virginia 22192	Active, not recruiting
Swedish Cancer Institute-Edmonds Edmonds, Washington 98026	Active, not recruiting
Swedish Cancer Institute-Issaquah Issaquah, Washington 98029	Active, not recruiting
Jefferson Healthcare Port Townsend, Washington 98368	Active, not recruiting
Swedish Medical Center-First Hill Seattle, Washington 98122	Active, not recruiting
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane, Washington 99204	Active, not recruiting
MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane, Washington 99218	Active, not recruiting
West Virginia University Charleston Division Charleston, West Virginia 25304	Active, not recruiting
West Virginia University Healthcare Morgantown, West Virginia 26506	Active, not recruiting
Camden Clark Medical Center Parkersburg, West Virginia 26101	Active, not recruiting
Langlade Hospital and Cancer Center Antigo, Wisconsin 54409	Active, not recruiting
ThedaCare Regional Cancer Center Appleton, Wisconsin 54911	Active, not recruiting
Ascension Saint Elizabeth Hospital Appleton, Wisconsin 54915	Active, not recruiting
Duluth Clinic Ashland Ashland, Wisconsin 54806	Active, not recruiting
Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield, Wisconsin 53045	Active, not recruiting
Marshfield Medical Center-EC Cancer Center Eau Claire, Wisconsin 54701	Active, not recruiting
Ascension Saint Francis - Reiman Cancer Center Franklin, Wisconsin 53132	Active, not recruiting
Bellin Memorial Hospital Green Bay, Wisconsin 54301	Active, not recruiting
Mercyhealth Hospital and Cancer Center - Janesville Janesville, Wisconsin 53548	Active, not recruiting
University of Wisconsin Carbone Cancer Center - Johnson Creek Johnson Creek, Wisconsin 53038	Active, not recruiting
Gundersen Lutheran Medical Center La Crosse, Wisconsin 54601	Active, not recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison, Wisconsin 53718	Active, not recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison, Wisconsin 53792	Active, not recruiting
Marshfield Medical Center-Marshfield Marshfield, Wisconsin 54449	Active, not recruiting
Aspirus Medford Hospital Medford, Wisconsin 54451	Active, not recruiting
Marshfield Medical Center - Minocqua Minocqua, Wisconsin 54548	Active, not recruiting
ProHealth D N Greenwald Center Mukwonago, Wisconsin 53149	Active, not recruiting
Cancer Center of Western Wisconsin New Richmond, Wisconsin 54017	Active, not recruiting
ProHealth Oconomowoc Memorial Hospital Oconomowoc, Wisconsin 53066	Active, not recruiting
Ascension Mercy Hospital Oshkosh, Wisconsin 54904	Active, not recruiting
Ascension All Saints Hospital Racine, Wisconsin 53405	Active, not recruiting
Aspirus Cancer Care - James Beck Cancer Center Rhinelander, Wisconsin 54501	Active, not recruiting
Marshfield Medical Center-Rice Lake Rice Lake, Wisconsin 54868	Active, not recruiting
Marshfield Medical Center-River Region at Stevens Point Stevens Point, Wisconsin 54482	Active, not recruiting
ProHealth Waukesha Memorial Hospital Waukesha, Wisconsin 53188	Active, not recruiting
UW Cancer Center at ProHealth Care Waukesha, Wisconsin 53188	Active, not recruiting
Aspirus Regional Cancer Center Wausau, Wisconsin 54401	Active, not recruiting
Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa, Wisconsin 53226	Active, not recruiting
Marshfield Medical Center - Weston Weston, Wisconsin 54476	Active, not recruiting
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids, Wisconsin 54494	Active, not recruiting
Cheyenne Regional Medical Center-West Cheyenne, Wyoming 82001	Active, not recruiting
Billings Clinic-Cody Cody, Wyoming 82414	Active, not recruiting

Inclusion Criteria

Inclusion Criteria:

* The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
* Age >= 18 years
* Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
* Diagnosis of metastatic adenocarcinoma of colon or rectum without previous chemotherapy or any other systemic therapy for metastatic colorectal cancer except for one cycle of FOLFOX or capecitabine and oxaliplatin (CAPOX), either with or without bevacizumab prior to enrollment. Upon enrollment, the preceding single cycle of FOLFOX or FOLFOX + bevacizumab, if the patient received one, will not count towards patients' assessments per protocol. Cycle 1 day 1 (C1D1) of atezolizumab or C1D1 of mFOLFOX6/bevacizumab + atezolizumab will correspond to the first day the patient received therapy on trial
* Tumor determined to be mismatch-repair deficient (dMMR) by Clinical Laboratory Improvement Act (CLIA)-certified immunohistochemical (IHC) assay with a panel of all four IHC markers, including MLH1, MSH2, PMS2, and MSH6; alternatively, MSI-H diagnosed by polymerase chain reaction (PCR)-based assessment of microsatellite alterations (either Bethesda markers or Pentaplex panel) or by next-generation sequencing (NGS) are eligible
* Documentation by PET/CT scan, CT scan, or MRI that the patient has measurable metastatic disease per RECIST 1.1
* No immediate need for surgical intervention for the primary tumor or palliative diversion/bypass
* Absolute neutrophil count (ANC) must be >= 1500/mm^3 (obtained within 28 days prior randomization)
* Platelet count must be >= 100,000/mm^3 (obtained within 28 days prior randomization)
* Hemoglobin must be >= 8 g/dL (obtained within 28 days prior randomization)
* Total bilirubin must be =< 4 x ULN (upper limit of normal) (obtained within 28 days prior randomization); and
* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be =< 3 x ULN for the lab with the following exception: for patients with documented liver metastases, AST and ALT must be =< 5 x ULN (obtained within 28 days prior randomization) * Calculated creatinine clearance >= 30 mL/min (obtained within 28 days prior randomization)
* A urine sample tested for proteinuria by either the dipstick method, urinalysis (UA), or a urine protein creatinine (UPC) ratio:

* The dipstick method must indicate 0-1+ protein; if dipstick reading is >= 2+, a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours or a UPC ratio < 1.0
* A urine protein creatinine (UPC) ratio must be < 1.0; if the UPC ratio is >= 1.0 a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours
* Urinalysis must indicate < 30 mg/dl. If urinalysis >= 30 mg/dl, a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours or a UPC ratio < 1.0
* International normalized ratio of prothrombin time (INR) and prothrombin time (PT) must be =< 1.5 x ULN for the lab within 28 days before randomization; patients who are therapeutically treated with an agent such as warfarin may participate if they are on a stable dose and no underlying abnormality in coagulation parameters exists per medical history, regardless of PT/INR results
* Pregnancy test done within 28 days prior randomization must be negative (for women of childbearing potential only); pregnancy testing should be performed according to institutional standards; administration of atezolizumab or mFOLFOX6/bevacizumab/atezolizumab may have an adverse effect on pregnancy and poses a risk to the human fetus, including embryo-lethality; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
* Women of child-bearing potential and men must agree to use adequate contraception methods that result in a failure rate of < 1% per year during the treatment period (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 5 months (150 days) after the last dose of atezolizumab, 6 months after the last dose of bevacizumab, and 6 months after the last dose of mFOLFOX6; a woman is considered to be of childbearing potential if she is not postmenopausal, has not reached a postmenopausal state (>= 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries and/or uterus); examples of contraceptive methods with a failure rate of < 1% per year include: bilateral tubal ligation; male partner sterilization; intrauterine devices; the reliability of sexual abstinence should be evaluated in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient; periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception; men must refrain from donating sperm during this same period

Exclusion Criteria

Exclusion Criteria:

* Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies, fluoropyrimidines, folic acid derivatives or oxaliplatin
* Uncontrolled high blood pressure defined as systolic blood pressure (BP) > 150 mmHg or diastolic BP > 100 mmHg with or without anti-hypertensive medication; patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria
* Documented New York Heart Association (NYHA) class III or IV congestive heart failure
* Serious or non-healing wound, skin ulcer, or bone fracture
* History of inherited bleeding diathesis, gastrointestinal (GI) perforation, significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent arterial thrombosis or symptomatic peripheral ischemia, transient ischemic attack [TIA], cerebrovascular accident [CVA] or arterial thrombotic event), abdominal fistula, intra-abdominal abscess, or active GI bleeding (with cause not addressed) within 6 months prior to randomization, or other medical condition in the opinion of the treating oncologist that makes the risk of cardiovascular or bleeding complications with bevacizumab use unacceptably high
* Other malignancies are excluded unless the patient has completed therapy for the malignancy >= 12 months prior to randomization and is considered disease-free; patients with the following cancers are eligible if diagnosed and treated within the past 12 months: in situ carcinomas or basal cell and squamous cell carcinoma of the skin
* Known DPD (dihydro pyrimidine dehydrogenase) deficiency
* Symptomatic peripheral sensory neuropathy >= grade 2 (Common Terminology Criteria for Adverse Events [CTCAE] version [v] 5.0)
* Prior treatment with oxaliplatin chemotherapy within 6 months prior to randomization
* History of grade 2 hemoptysis (defined as 2.5 mL of bright red blood per episode) within 1 month prior to screening
* Prior treatment with anti-PD-1, or anti-PD-L1 therapeutic antibody or pathway-targeting agents; patients who have received prior treatment with anti-CTLA-4 may be enrolled provided the following requirements are met:

* Minimum of 12 weeks from the first dose of anti-CTLA-4 and > 6 weeks from the last dose to randomization
* No history of severe immune-related adverse effects (CTCAE grade 3 and 4) from anti-CTLA-4
* Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF] agents) within 14 days prior to randomization; however,

* Patients who have received acute, low dose, systemic immunosuppressant medications (e.g., a one-time dose of dexamethasone for nausea; or chronic daily treatment with corticosteroids with a dose of =< 10 mg/day methylprednisolone equivalent) may be enrolled
* The use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) for patients with orthostatic hypotension or adrenocortical insufficiency is allowed
* Known clinically significant liver disease, including active viral, alcoholic, or other hepatitis; cirrhosis; fatty liver; and inherited liver disease; however,

* Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen [HbsAg] test and a positive anti-HBc [antibody to hepatitis B core antigen] antibody test) are eligible if polymerase chain reaction (PCR) for hepatits B virus (HBV) ribonucleic acid (RNA) is negative per local guidelines
* Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV RNA per local guidelines
* History or risk of autoimmune disease, including, but not limited to, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis; however,

* Patients with a history of autoimmune hypothyroidism on a stable dose of thyroid replacement hormone may be eligible
* Patients with controlled type 1 diabetes mellitus on a stable insulin regimen may be eligible
* Patients with eczema, psoriasis, lichen simplex chronicus or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis would be excluded) are permitted provided that they meet the following conditions:

* Patients with psoriasis must have a baseline ophthalmologic exam to rule out ocular manifestations
* Rash must cover less than 10% of body surface area (BSA)
* Disease is well controlled at baseline and only requiring low potency topical steroids (e.g., hydrocortisone 2.5%, hydrocortisone butyrate 0.1%, fluocinolone 0.01%, desonide 0.05%, alclometasone dipropionate 0.05%)
* No acute exacerbations of underlying condition within the last 12 months (not requiring psoralen plus ultraviolet A radiation [PUVA], methotrexate, retinoids, biologic agents, oral calcineurin inhibitors; high potency or oral steroids)
* History of idiopathic pulmonary fibrosis, organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or active or recently active (within 90 days of randomization) pneumonitis (including drug induced) that required systemic immunosuppressive therapy (i.e. corticosteroids, etc.). History of radiation pneumonitis in the radiation field (fibrosis) is permitted
* History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
* Patients with known active tuberculosis (TB) are excluded
* Severe infections within 28 days prior to randomization, including but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia
* Signs or symptoms of infection within 14 days prior to randomization
* Received oral or intravenous (IV) antibiotics within 14 days prior to randomization; patients receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are eligible
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to randomization or anticipation of need for a major surgical procedure during the course of the study
* The administration of a live, attenuated vaccine within 28 days prior to randomization
* Pregnant women are excluded from this study because atezolizumab is an agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with atezolizumab, breastfeeding should be discontinued if the mother is treated with atezolizumab; these potential risks may also apply to other agents used in this study; (Note: pregnancy testing should be performed within 28 days prior to randomization according to institutional standards for women of childbearing potential)
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
* Patients with prior allogeneic bone marrow transplantation or prior solid organ transplantation

NCT ID

NCT02997228

Date Trial Added

2016-12-20

Updated Date

2025-09-05