Program Status
Active, not recruitingPhase
Phase 1Prior Immunotherapy Allowed
YesCRC-directed Trial
NoTags
MSI-H/ MMRd, MSS/ MMRpComments
AB248: CD8+ T cell-selective IL-2 with over 500-fold preference for CD8+ T cells over other immune cell types.
Pembrolizumab: anti PD-1, immunotherapy.
AB248 alone or in combination with pembrolizumab. Prior anti PD-1/ L1 checkpoint inhibitor seems OK, but not prior immunotherapy that targets IL-2, IL-7, or IL-15 receptors. For solid tumors.
| Location | Location Status |
|---|---|
| United States | |
|
City of Hope Duarte, California 91010 |
Active, not recruiting |
|
UCLA Los Angeles, California 90095 |
Active, not recruiting |
|
UCSD San Diego, California 92037 |
Active, not recruiting |
|
UCSF San Francisco, California 94143 |
Active, not recruiting |
|
Yale New Haven, Connecticut 06510 |
Active, not recruiting |
|
University of Miami Miami, Florida 33136 |
Active, not recruiting |
|
Ocala Oncology Center Ocala, Florida 34474 |
Active, not recruiting |
|
University of Chicago Medical Center Chicago, Illinois 60637 |
Active, not recruiting |
|
Massachusetts General Hospital Boston, Massachusetts 02114 |
Active, not recruiting |
|
Dana Farber Cancer Institute Boston, Massachusetts 02215 |
Active, not recruiting |
|
Karmanos Cancer Institute Detroit, Michigan 48201 |
Active, not recruiting |
|
Washington University St Louis, Missouri 63110 |
Active, not recruiting |
|
Rutgers New Brunswick, New Jersey 08901 |
Active, not recruiting |
|
NYU New York, New York 10016 |
Active, not recruiting |
|
Memorial Sloan Kettering Cancer Center New York, New York 10065 |
Active, not recruiting |
|
UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina 27599 |
Active, not recruiting |
|
Providence Cancer Institute Franz Clinic Portland, Oregon 97213 |
Active, not recruiting |
|
Sarah Cannon Research Institute Nashville, Tennessee 37203 |
Active, not recruiting |
|
Intermountain Health Murray, Utah 84107 |
Active, not recruiting |
|
Virginia Commonwealth Richmond, Virginia 23298 |
Active, not recruiting |
Inclusion Criteria
Inclusion Criteria:
* Age ≥18 years of age at the time consent is signed.
* Has adequate end organ function per laboratory testing.
* Pregnancy prevention requirements
* Has measurable disease per RECIST 1.1 as assessed by the local site Investigator/radiology.
* Has a performance status of 0 or 1 on Eastern Cooperative Oncology Group scale.
* Histologic documentation of incurable, locally advanced or metastatic tumor of the type being evaluated in individual cohorts
Exclusion Criteria
Exclusion Criteria:
* Has a diagnosis of immunodeficiency.
* Has a history of a previous, additional malignancy, unless potentially curative treatment has been completed, with no evidence of malignancy for 5 years.
* Has known active CNS metastases and/or carcinomatous meningitis.
* Has an active autoimmune disease that has required systemic treatment in the past 2 years.
* Has an active infection requiring systemic therapy.
* Inability to comply with study and follow-up procedures.
* Has had a severe hypersensitivity reaction (Grade ≥3) to treatment with pembrolizumab, another monoclonal antibody, or has history of any hypersensitivity to any components of the study treatments or any of their excipients.
* Has received prior systemic anticancer therapy including investigational agents within 4 weeks (or, if shorter, within 5 half-lives for kinase inhibitors) prior to first dose of study treatment.
* Has received prior radiotherapy within 2 weeks of start of study treatment or has had a history of radiation pneumonitis.
* Receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior the first dose of study treatment.
* Has received previous treatment with another agent targeting the IL-2, IL-7, or IL-15 receptors.
* Is expected to require any other form of antineoplastic therapy while on study
