Clinical Trial Finder Search Results

About the Fight CRC Clinical Trial Finder

This Trial Finder is a one-stop place to find and learn more about high-impact clinical trials for colorectal cancer patients with advanced colon or rectal cancer. Originally created by the late Dr. Tom Marsilje as a curated spreadsheet of trials, the FightCRC’s Trial Finder is a resource to find research studies that are open in your geography, and for which you may be eligible. The current data is now for metastatic, stage IV patients with both MSS and MSI-H status. The list of trials here is sourced from the ClinicalTrials.gov website and curated with Comments and Helpful Links. The searches can be focused on immunotherapy-centered trials and narrowed to studies enrolling patients who already have received immunotherapies.

Medical Disclaimer

The information contained in this website is not intended to recommend the self management of health problems, medical conditions or wellness. It is not intended to endorse or recommend any particular type of medical treatment, physician or treatment facility. Should any reader have any health care related questions, promptly call or consult your physician or healthcare provider. The information contained in this website should NOT be used by any reader to disregard medical and/or health related advice or provide a basis to delay consultation with a physician or a qualified healthcare provider. Fight Colorectal Cancer disclaims any liability based on information provided in this website.

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NCT ID	Title	Phase	Date Added	Location	Prior IO Allowed	CRC-directed	Status	Drugs	Tags
NCT ID NCT03069469	TitleStudy of DCC-3014 in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor	Phase Phase 1, Phase 2	Date Added 2017-03-03	Location California, United States Colorado, United States Florida, United States Massachusetts, United States New York, United States Oregon, United States Tennessee, United States Australia Canada France Italy Netherlands Poland Spain United Kingdom	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs DCC-3014	Tags MSS/ MMRp
NCT ID NCT03829462	TitleAssessing a Regorafenib-irinotecan Combination Versus Regorafenib Alone in Metastatic Colorectal Cancer Patients	Phase Phase 3	Date Added 2019-02-04	Location France	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Irinotecan, Regorafenib	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT04096417	TitlePemigatinib for the Treatment of Metastatic or Unresectable Colorectal Cancer Harboring FGFR Alterations	Phase Phase 2	Date Added 2019-09-19	Location Arizona, United States Georgia, United States Minnesota, United States North Carolina, United States Tennessee, United States Wisconsin, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Pemigatinib	Tags MSS/ MMRp
NCT ID NCT04793958	TitlePhase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)	Phase Phase 3	Date Added 2021-03-11	Location Alabama, United States Arizona, United States Arkansas, United States California, United States Colorado, United States Connecticut, United States Florida, United States Georgia, United States Illinois, United States Indiana, United States Iowa, United States Louisiana, United States Maryland, United States Massachusetts, United States Michigan, United States Minnesota, United States Missouri, United States Nebraska, United States Nevada, United States New Jersey, United States New York, United States North Carolina, United States Ohio, United States Oklahoma, United States Pennsylvania, United States South Carolina, United States Tennessee, United States Texas, United States Utah, United States Virginia, United States Washington, United States West Virginia, United States Wisconsin, United States Argentina Australia Austria Belgium Brazil Canada China Colombia Czechia Denmark Finland France Germany Greece Hong Kong Ireland Italy Korea, Republic of Malaysia Mexico Netherlands Poland Portugal Puerto Rico Romania Singapore Spain Taiwan Thailand Ukraine United Kingdom	Prior IO Allowed Yes	CRC-directed Yes	Status Active, not recruiting	Drugs cetuximab, FOLFIRI Regimen, mFOLFOX6 Regimen, MRTX849	Tags MSI-H/ MMRd, MSS/ MMRp
NCT ID NCT04599140	TitleSX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 Trial	Phase Phase 1, Phase 2	Date Added 2020-10-22	Location Texas, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs CXCR1/2 Inhibitor SX-682, Nivolumab	Tags MSS/ MMRp
NCT ID NCT03650348	TitlePRS-343 in Combination With Atezolizumab in HER2-Positive Solid Tumors	Phase Phase 1	Date Added 2018-08-28	Location California, United States Louisiana, United States New York, United States Ohio, United States Texas, United States	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs PRS-343 in Combination with Atezolizumab, Tecentriq	Tags MSS/ MMRp
NCT ID NCT04724239	TitleA Study of Sintilimab and Chidamide in Combination With or Without IBI305 in Standard Treatment Failure of Advanced or Metastatic pMMR/MSS Colorectal Carcinoma	Phase Phase 2	Date Added 2021-01-26	Location China	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs chidamide, IBI305, Sintilimab	Tags MSS/ MMRp
NCT ID NCT02537418	TitleDurvalumab With or Without Tremelimumab in Advanced Incurable Solid Malignancies Given With or Without Standard Chemotherapy Regimens	Phase Phase 1	Date Added 2015-09-01	Location Canada	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs durvalumab, Tremelimumab, Imfinzi	Tags MSS/ MMRp
NCT ID NCT03626922	TitleStudy of Pembrolizumab With Pemetrexed and Oxaliplatin in Chemo-Refractory Metastatic Colorectal Cancer Patients	Phase Phase 1	Date Added 2018-08-13	Location Florida, United States Illinois, United States Michigan, United States Minnesota, United States Pennsylvania, United States	Prior IO Allowed No	CRC-directed Yes	Status Active, not recruiting	Drugs Dexamethasone, oxaliplatin, Pembrolizumab, Pemetrexed, Alimta, Eloxatin, Keytruda	Tags MSS/ MMRp
NCT ID NCT04185883	TitleSotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)	Phase Phase 1	Date Added 2019-12-04	Location Arizona, United States California, United States Colorado, United States Connecticut, United States Florida, United States Georgia, United States Illinois, United States Indiana, United States Iowa, United States Maryland, United States Michigan, United States Missouri, United States New York, United States North Carolina, United States Ohio, United States Oregon, United States Pennsylvania, United States South Carolina, United States South Dakota, United States Tennessee, United States Texas, United States Utah, United States Virginia, United States Washington, United States Australia Austria Belgium Canada Germany Italy Japan Netherlands South Korea Spain Taiwan United Kingdom	Prior IO Allowed Yes	CRC-directed No	Status Active, not recruiting	Drugs afatinib, AMG 404, Atezolizumab, carboplatin, pemetrexed, docetaxel, everolimus, FOLFIRI, FOLFOX, MVASI® (bevacizumab-awwb), palbociclib, panitumumab, Pembrolizumab, RMC-4630, Sotorasib, TNO155, Trametinib	Tags MSI-H/ MMRd, MSS/ MMRp

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