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Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Program Status

Recruiting

Phase

Phase 3

Immunotherapy-centered Trial

Prior Immunotherapy Allowed

Yes

CRC-directed Trial

Yes

Drugs

cetuximab, FOLFIRI Regimen, mFOLFOX6 Regimen, MRTX849

Location	Location Status
United States
Research Site Birmingham, Alabama 35205	Recruiting
Research Site Gilbert, Arizona 85234	Recruiting
Research Site Goodyear, Arizona 85338	Recruiting
Research Site Phoenix, Arizona 85054	Recruiting
Research Site Springdale, Arkansas 72762	Recruiting
Research Site Bakersfield, California 93309	Recruiting
Research Site Clovis, California 93611	Recruiting
Research Site Fullerton, California 92835	Recruiting
Research Site Los Angeles, California 90033	Recruiting
Research Site Los Angeles, California 90048	Recruiting
Research Site Redlands, California 92373	Recruiting
Research Site San Diego, California 92123	Recruiting
Research Site San Francisco, California 94115	Recruiting
Research Site Santa Monica, California 90404	Recruiting
Research Site Sylmar, California 91342	Recruiting
Research Site Torrance, California 90505	Recruiting
Research Site Whittier, California 90602	Recruiting
Research Site Aurora, Colorado 80045	Withdrawn
Research Site Denver, Colorado 80218	Recruiting
Research Site Norwich, Connecticut 06360	Recruiting
Research Site Fort Myers, Florida 33901	Recruiting
Research Site Jacksonville, Florida 32224	Recruiting
Research Site Miami, Florida 33136	Withdrawn
Research Site Ocala, Florida 34471	Recruiting
Research Site Orlando, Florida 32804	Recruiting
Research Site Orlando, Florida 32806	Recruiting
Research Site Saint Petersburg, Florida 33705	Recruiting
Research Site Saint Petersburg, Florida 33709	Recruiting
Research Site Tallahassee, Florida 32308	Recruiting
Research Site West Palm Beach, Florida 33401	Recruiting
Research Site Weston, Florida 33331	Recruiting
Research Site Atlanta, Georgia 30322	Withdrawn
Research Site Newnan, Georgia 30265	Withdrawn
Research Site Naperville, Illinois 60540	Recruiting
Research Site Zion, Illinois 60099	Recruiting
Research Site Indianapolis, Indiana 46237	Recruiting
Research Site Iowa City, Iowa 52242	Recruiting
Research Site Baton Rouge, Louisiana 70809	Recruiting
Research Site Baltimore, Maryland 21201	Recruiting
Research Site Boston, Massachusetts 02114	Recruiting
Research Site Detroit, Michigan 48202	Recruiting
Research Site Minneapolis, Minnesota 55404	Recruiting
Research Site Rochester, Minnesota 55905	Recruiting
Research Site Saint Paul, Minnesota 55101	Recruiting
Research Site Springfield, Missouri 65804	Recruiting
Research Site Lincoln, Nebraska 68510	Recruiting
Research Site Omaha, Nebraska 68130	Recruiting
Research Site Las Vegas, Nevada 89169	Recruiting
Research Site Belleville, New Jersey 07109	Recruiting
Research Site Florham Park, New Jersey 07932	Recruiting
Research Site New Brunswick, New Jersey 08903	Recruiting
Research Site Somerset, New Jersey 08873-5002	Recruiting
Research Site New York, New York 10016	Recruiting
Research Site New York, New York 10029	Recruiting
Research Site New York, New York 10065	Recruiting
Research Site Port Jefferson Station, New York 11776	Recruiting
Research Site Jacksonville, North Carolina 28546	Recruiting
Research Site Sparta, North Carolina 28675	Recruiting
Research Site Cincinnati, Ohio 45211	Recruiting
Research Site Oklahoma City, Oklahoma 73104	Recruiting
Research Site Oklahoma City, Oklahoma 73120	Recruiting
Research Site Tulsa, Oklahoma 74146	Recruiting
Research Site Greenville, South Carolina 29607	Withdrawn
Research Site Chattanooga, Tennessee 37404	Recruiting
Research Site Nashville, Tennessee 37203	Recruiting
Research Site Dallas, Texas 75216	Recruiting
Research Site Dallas, Texas 75246	Recruiting
Research Site Houston, Texas 77030	Recruiting
Research Site Houston, Texas 77090	Recruiting
Research Site Longview, Texas 75601	Recruiting
Research Site San Antonio, Texas 78240	Recruiting
Research Site Temple, Texas 76508	Recruiting
Research Site Salt Lake City, Utah 84106	Recruiting
Research Site Fairfax, Virginia 22031	Recruiting
Research Site Fredericksburg, Virginia 24408	Recruiting
Research Site Richmond, Virginia 23230	Recruiting
Research Site Richmond, Virginia 23298	Recruiting
Research Site Everett, Washington 98201	Recruiting
Research Site Seattle, Washington 98109	Recruiting
Research Site Tacoma, Washington 98405	Recruiting
Research Site Vancouver, Washington 98684	Recruiting
Research Site Morgantown, West Virginia 26506	Recruiting
Research Site Milwaukee, Wisconsin 53226	Recruiting
Argentina
Research Site Viedma, Rio Negro R8500ACE	Recruiting
Research Site Buenos Aires C1061AAS	Recruiting
Research Site Buenos Aires C1426ANZ	Recruiting
Research Site Buenos Aires CI264 AAA	Recruiting
Research Site La Rioja F5300COE	Recruiting
Australia
Research Site Waratah, New South Wales 2298	Recruiting
Research Site Bedford Park, South Australia 5042	Recruiting
Research Site Clayton, Victoria 3168	Recruiting
Research Site Heidelberg, Victoria 3084	Recruiting
Research Site Melbourne, Victoria 3004	Recruiting
Research Site Garran 2605	Recruiting
Austria
Research Site Innsbruck, Tyrol 6020	Recruiting
Research Site Wiener Neustadt 2700	Recruiting
Research Site Wien 1090	Recruiting
Belgium
Research Site Edegem, Antwerpen 2650	Recruiting
Research Site Brussels 1090	Recruiting
Research Site Gent 9000	Recruiting
Research Site Yvoir 5530	Recruiting
Brazil
Research Site Porto Alegre, Rio Grande Do Sul 90035-903	Recruiting
Research Site Porto Alegre, Rio Grande Do Sul 91350-200	Recruiting
Research Site Blumenau, Santa Catarina 89010-340	Recruiting
Research Site Curitiba 80520-174	Recruiting
Research Site Ijuí 98700-000	Recruiting
Research Site Sao Paulo 01509-010	Recruiting
Research Site São Paulo 01246	Recruiting
Research Site São Paulo 01323-030	Recruiting
Research Site São Paulo 04543-000	Recruiting
Research Site São Paulo 09060-650	Recruiting
Research Site São Paulo 15090-000	Recruiting
Canada
Research Site Ottawa, Ontario K1H 8L6	Recruiting
Research Site Toronto, Ontario M5B 1W8	Recruiting
Research Site Montréal, Quebec H1T 2M4	Recruiting
Research Site Toronto M5G 2M9	Recruiting
China
Research Site Bengbu, Anhui 233004	Recruiting
Research Site Hefei, Anhui 230031	Recruiting
Research Site Hefei, Anhui 230088	Recruiting
Research Site Fuzhou, Fujian 350014	Recruiting
Research Site Guangzhou, Guang Dong 510655	Recruiting
Research Site Shenzhen, Guang Dong 518036	Recruiting
Research Site Nanning, Guangxi 530000	Recruiting
Research Site Harbin, Heilongjiang 150081	Recruiting
Research Site Zhengzhou, Henan	Recruiting
Research Site Wuhan, Hubei	Recruiting
Research Site Changsha, Hunan 410008	Recruiting
Research Site Changsha, Hunan 410013	Recruiting
Research Site Nanjing, Jiangsu 210029	Recruiting
Research Site Wuxi, Jiangsu 214400	Recruiting
Research Site Nanchang, Jiangxi	Recruiting
Research Site Changchun, Jilin 130000	Recruiting
Research Site Changchun, Jilin 130015	Recruiting
Research Site Shenyang, Liaoning 110042	Recruiting
Research Site Shenyang, Liaoning 110101	Recruiting
Research Site Shanghai, Pudong 201321	Recruiting
Research Site Jinan, Shandong 250117	Recruiting
Research Site Chengdu, Sichuan 610041	Recruiting
Research Site Neijiang, Sichuan 641100	Recruiting
Research Site Hangzhou, Zhejiang 310017	Recruiting
Research Site Hangzhou, Zhejiang 310022	Recruiting
Research Site Beijing 100021	Recruiting
Research Site Beijing 100142	Recruiting
Research Site Shanghai 200025	Recruiting
Research Site Shanghai 200032	Recruiting
Research Site Shanghai 200123	Recruiting
Research Site Shanghai 201620	Recruiting
Research Site Tianjin 300060	Recruiting
Research Site Xi'an 710068	Recruiting
Colombia
Research Site Floridablanca, Santander 681001	Recruiting
Research Site Barranquilla 080020	Recruiting
Research Site Bogotá 111511-110411001	Recruiting
Research Site Medellín 050034	Recruiting
Czechia
Research Site Praha, Prague 150 06	Recruiting
Research Site Brno, South Moravian 656 53	Recruiting
Research Site Brno, South Moravian 656 91	Recruiting
Research Site Olomouc 779 00	Recruiting
Research Site Prague 128 08	Recruiting
Denmark
Research Site Copenhagen 2100	Recruiting
Research Site Odense DK 5000	Recruiting
Research Site Vejle 7100	Recruiting
Finland
Research Site Helsinki 00290	Recruiting
Research Site Tampere 33520	Recruiting
Research Site Turku 20520	Recruiting
France
Research Site Dijon, Bourgogne 21079	Recruiting
Research Site Brest, Bretagne 29200	Recruiting
Research Site Besançon, Doubs 25000	Recruiting
Research Site Lille, Hauts-de-France 59037	Recruiting
Research Site Paris, Ile-de-France 75015	Recruiting
Research Site Toulouse, Midi-Pyrenees 31059	Recruiting
Research Site Avignon, Provence Alpes Cote d'Azure 84918	Recruiting
Research Site Lyon, Rhone-Alpes 69008	Recruiting
Research Site Bourdeaux, Rhone 33000	Recruiting
Research Site Villejuif, Val-de-Marne 94805	Recruiting
Research Site Marseille 13005	Recruiting
Research Site Paris 75010	Recruiting
Research Site Paris 75012	Recruiting
Research Site Paris 75013	Recruiting
Research Site Pessac 33720	Recruiting
Research Site Suresnes 92150	Recruiting
Research Site Tours 37044	Recruiting
Germany
Research Site Ulm, Baden-Wuerttemberg 89081	Recruiting
Research Site Reutlingen, Baden-Wurttemberg	Recruiting
Research Site München, Bayern 81737	Recruiting
Research Site Frankfurt, Hessen 60488	Recruiting
Research Site Bochum, Nordrhein-Westfalen 44791	Recruiting
Research Site Dresden, Sachsen 01307	Recruiting
Research Site Amberg 92224	Recruiting
Research Site Berlin 10117	Recruiting
Research Site Hamburg 20246	Recruiting
Research Site Herne 44625	Recruiting
Research Site Monchengladbach 41063	Recruiting
Research Site München 81377	Recruiting
Greece
Research Site Larissa, Thessaly 41110	Recruiting
Research Site Athens 11528	Recruiting
Research Site Athens 15562	Recruiting
Research Site Heraklion 71110	Recruiting
Research Site Thessaloniki 54645	Recruiting
Research Site Thessaloníki 57001	Recruiting
Hong Kong
Research Site Central 1401-02	Recruiting
Research Site Hong Kong	Recruiting
Ireland
Research Site Dublin D04 Y8V0	Recruiting
Research Site Dublin D07 R2WY	Recruiting
Research Site Dublin D09V2N0	Recruiting
Research Site Dublin D24 NR0A	Recruiting
Italy
Research Site Lido Di Camaiore, Lucca 55041	Recruiting
Research Site Candiolo, Torino 10060	Recruiting
Research Site Avellino 81300	Recruiting
Research Site Biella 13875	Recruiting
Research Site Cagliari 9042	Recruiting
Research Site Meldola 47014	Recruiting
Research Site Milano 20162	Recruiting
Research Site Milan 20141	Recruiting
Research Site Naples 80131	Recruiting
Research Site Padova 35128	Recruiting
Research Site Pisa 56126	Recruiting
Research Site Reggio Emilia 42100	Recruiting
Research Site Roma 00144	Recruiting
Research Site Turin 10128	Recruiting
Korea, Republic of
Research Site Anyang-si, Gyeonggi-do 14068	Recruiting
Research Site Seongnam-si, Gyeonggi-do 13496	Recruiting
Research Site Yangsan, Gyeongsangnam 50612	Recruiting
Research Site Hwasun, Jeollanam-do 58128	Recruiting
Research Site Busan 48108	Recruiting
Research Site Busan 49201	Recruiting
Research Site Daejeon 35015	Recruiting
Research Site Goyang-si 10408	Recruiting
Research Site Seoul 02841	Recruiting
Research Site Seoul 03080	Recruiting
Research Site Seoul 037722	Recruiting
Research Site Seoul 05505	Recruiting
Research Site Seoul 06351	Recruiting
Research Site Seoul 06591	Recruiting
Research Site Sŏwŏn 16247	Recruiting
Malaysia
Research Site Kota Kinabalu, Sabah 88996	Recruiting
Research Site Kuala Lumpur, Selangor 50586	Recruiting
Research Site Kuala Lumpur, Selangor 59100	Recruiting
Research Site Petaling Jaya, Selangor 46050	Recruiting
Research Site Johor Bahru 81100	Recruiting
Research Site Putrajaya 62250	Recruiting
Mexico
Research Site Tuxtla Gutiérrez, Chiapas 29038	Recruiting
Research Site Guadalajara, Jalisco 44280	Recruiting
Research Site Guadalajara, Jalisco 44670	Recruiting
Research Site Cuernavaca, Morelos 62290	Recruiting
Research Site San Juan Del Río, Queretaro 76800	Recruiting
Research Site Mexico City 14080	Recruiting
Research Site Veracruz 94300	Recruiting
Netherlands
Research Site Nijmegen, Gelderland 6525 GA	Recruiting
Research Site Amsterdam, Noor-Holland 1081	Recruiting
Research Site Amsterdam, Noord-Holland 1066 CX	Recruiting
Research Site Nieuwegein, Utrecht 3435 CM	Recruiting
Poland
Research Site Gdańsk 80-219	Recruiting
Research Site Otwock 05-400	Recruiting
Research Site Warsaw 02-034	Recruiting
Research Site Warsaw 02-507	Recruiting
Portugal
Research Site Braga 4710-243	Recruiting
Research Site Lisboa 1400-038	Recruiting
Research Site Lisbon 1649-035	Recruiting
Research Site Porto 4099-001	Recruiting
Research Site Porto 4200-072	Recruiting
Puerto Rico
Research Site San Juan 00935	Recruiting
Research Site San Juan	Recruiting
Romania
Research Site Ovidiu, Constanta 905900	Recruiting
Research Site Baia Mare 430031	Recruiting
Research Site Braşov 500152	Recruiting
Research Site Bucuresti 022328	Recruiting
Research Site Cluj-Napoca 400015	Recruiting
Research Site Cluj-Napoca 400641	Recruiting
Research Site Craiova 200746	Recruiting
Research Site Timişoara 300239	Recruiting
Singapore
Research Site Singapore 119074	Recruiting
Research Site Singapore 169610	Recruiting
Research Site Singapore 188770	Recruiting
Research Site Singapore 217562	Recruiting
Research Site Singapore 258499	Recruiting
Spain
Research Site Badalona, Barcelona 08916	Recruiting
Research Site A Coruña 15006	Recruiting
Research Site Barcelona 08035	Recruiting
Research Site Barcelona 08036	Recruiting
Research Site Barcelona 08908	Recruiting
Research Site Córdoba 14004	Recruiting
Research Site Madrid 28007	Recruiting
Research Site Madrid 28040	Recruiting
Research Site Madrid 28041	Recruiting
Research Site Madrid 28046	Recruiting
Research Site Pamplona 31008	Recruiting
Research Site Sabadell 08208	Recruiting
Research Site Santander 39008	Recruiting
Research Site Valencia 46010	Recruiting
Research Site Valencia 46014	Recruiting
Taiwan
Research Site Changhua 500	Recruiting
Research Site Kaohsiung 807	Recruiting
Research Site Taichung 407	Recruiting
Research Site Tainan 704	Recruiting
Research Site Tainan 736	Recruiting
Research Site Taipei 100	Recruiting
Research Site Taoyuan 333	Recruiting
Thailand
Research Site Bangkok 10110	Recruiting
Research Site Bangkok 10400	Recruiting
Research Site Bangkok 10700	Recruiting
Research Site Chiang Mai 50200	Recruiting
Research Site Hat Yai 90110	Recruiting
United Kingdom
Research Site Bournemouth, Dorset BH7 7DW	Recruiting
Research Site Birmingham, England B91 2PP	Recruiting
Research Site Cambridge, England CB2 0QQ	Recruiting
Research Site Leeds, England LS9 7TF	Recruiting
Research Site London, England NW1 2BD	Recruiting
Research Site London, England SW3 6JJ	Recruiting
Research Site Maidstone, England ME16 9QQ	Recruiting
Research Site Manchester, England M20 4BX	Recruiting
Research Site Middlesex, England HA6 2RN	Recruiting
Research Site Sutton, England SM2 5PT	Recruiting
Research Site Aberdeen, Scotland AB25 2ZN	Recruiting
Research Site Glasgow, Scotland G12 0YN	Recruiting

Contacts

Mirati Therapeutics Study Locator Services
Contact
1-844-893-5530 miratistudylocator@careboxhealth.com

Inclusion Criteria

Inclusion Criteria:

Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria

Exclusion Criteria:

Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
Active brain metastasis

NCT ID

NCT04793958

Date Trial Added

2021-03-11

Updated Date

2023-08-23

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