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Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Program Status

Active, not recruiting

Phase

Phase 3

Immunotherapy-centered Trial

Prior Immunotherapy Allowed

Yes

CRC-directed Trial

Yes

Drugs

cetuximab, FOLFIRI Regimen, mFOLFOX6 Regimen, MRTX849

Tags

MSI-H/ MMRd, MSS/ MMRp

Helpful Links

Adagrasib With or Without Cetuximab Elicits Responses in Advanced KRAS G12C–Mutated CRC FDA Approves Adagrasib for Locally Advanced or Metastatic KRAS G12C+ NSCLC https://www.nejm.org/doi/full/10.1056/NEJMoa2212419 Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer Adagrasib Plus Cetuximab May Provide Clinical Benefit in Patients With KRASG12C-mutated Colorectal Cancer

Location	Location Status
United States
Alabama Oncology - St. Vincents Birmingham Birmingham, Alabama 35243	Active, not recruiting
Banner MD Anderson Cancer Center Gilbert, Arizona 85234	Active, not recruiting
City of Hope Phoenix Goodyear, Arizona 85338	Active, not recruiting
Mayo Clinic Hospital - Phoenix Phoenix, Arizona 85054	Active, not recruiting
Highlands Oncology Group - Springdale Springdale, Arkansas 72762	Active, not recruiting
Comprehensive Blood and Cancer Center - Bakersfield Bakersfield, California 93309	Active, not recruiting
University of California San Francisco - Fresno Center for Medical Education and Research Fresno, California 93701	Active, not recruiting
Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton Fullerton, California 92835	Active, not recruiting
Norris Comprehensive Cancer Center Los Angeles, California 90033	Active, not recruiting
Samuel Oschin Comprehensive Cancer Institute Los Angeles, California 90048	Active, not recruiting
Local Institution - 010-563 Redlands, California 92373	Active, not recruiting
Sharp Memorial Hospital San Diego, California 92123	Active, not recruiting
California Pacific Medical Center Research Institute San Francisco, California 94115	Active, not recruiting
UCLA Health - Santa Monica Parkside Cancer Care Santa Monica, California 90404	Active, not recruiting
Olive View - University of California Los Angeles Medical Center Sylmar, California 91342	Active, not recruiting
Torrance Memorial Physician Network - Cancer Care and Infusion Center Torrance, California 90505	Active, not recruiting
PIH Health Whittier, California 90602	Active, not recruiting
UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center Aurora, Colorado 80045	Active, not recruiting
USOR - Rocky Mountain Cancer Centers - Denver - Midtown Denver, Colorado 80218	Active, not recruiting
Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut 06360	Active, not recruiting
SCRI - Florida Cancer Specialists - South Region Research Office Fort Myers, Florida 33901	Active, not recruiting
Mayo Clinic - Jacksonville Jacksonville, Florida 32224	Active, not recruiting
Sylvester Comprehensive Cancer Center Miami, Florida 33136	Active, not recruiting
Florida Cancer Affiliates - Ocala - Main Ocala, Florida 34474	Active, not recruiting
AdventHealth Cancer Institute Orlando, Florida 32804	Active, not recruiting
Orlando Health Orlando, Florida 32806	Active, not recruiting
SCRI - Florida Cancer Specialists - North Region Research Office Saint Petersburg, Florida 33705	Active, not recruiting
Comprehensive Hematology Oncology LLC - Park Street Clinic Saint Petersburg, Florida 33709-2236	Active, not recruiting
SCRI - Florida Cancer Specialists - Panhandle Research Office Tallahassee, Florida 32308	Active, not recruiting
SCRI - Florida Cancer Specialists - East Region Research Office West Palm Beach, Florida 33401	Active, not recruiting
Cleveland Clinic Florida Weston, Florida 33331	Active, not recruiting
Emory University Atlanta, Georgia 30322	Active, not recruiting
City of Hope Atlanta Newnan, Georgia 30265	Active, not recruiting
Edward Hospital - Main Campus Naperville, Illinois 60540	Active, not recruiting
City of Hope Chicago Zion, Illinois 60099	Active, not recruiting
Franciscan Physician Network Oncology & Hematology Specialists Indianapolis Indianapolis, Indiana 46237-8601	Active, not recruiting
University of Iowa Hospitals and Clinics Iowa City, Iowa 52242	Active, not recruiting
SCRI - Hematology Oncology Clinic - Baton Rouge Baton Rouge, Louisiana 70809	Active, not recruiting
University of Maryland Baltimore, Maryland 21201	Active, not recruiting
Massachusetts General Hospital Boston, Massachusetts 02114	Active, not recruiting
Henry Ford Hospital Detroit, Michigan 48202	Active, not recruiting
Minnesota Oncology - Edina Clinic Minneapolis, Minnesota 55404	Active, not recruiting
Mayo Clinic - Rochester Rochester, Minnesota 55905	Active, not recruiting
HealthPartners Cancer Research Center - Cancer Center at Regions Hospital Saint Louis Park, Minnesota 55416	Active, not recruiting
Mercy Research - Smith Glynn Callaway Springfield, Missouri 65804	Active, not recruiting
Southeast Nebraska Cancer Center - 68th Street Location Lincoln, Nebraska 68510	Active, not recruiting
Nebraska Cancer Specialists - Midwest Cancer Center - Legacy Omaha, Nebraska 68130	Active, not recruiting
Comprehensive Cancer Centers of Nevada - Central Valley - Twain Las Vegas, Nevada 89169	Active, not recruiting
New Jersey Cancer Care Belleville, New Jersey 07109	Active, not recruiting
Astera Cancer Care - East Brunswick East Brunswick, New Jersey 08816	Active, not recruiting
Summit Medical Group - Florham Park Campus Florham Park, New Jersey 07932	Active, not recruiting
Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey 08903-2681	Active, not recruiting
Perlmutter Cancer Center - 34th Street New York, New York 10016	Active, not recruiting
Icahn School of Medicine at Mount Sinai New York, New York 10029	Active, not recruiting
Memorial Sloan Kettering Cancer Center - New York New York, New York 10065	Active, not recruiting
New York Cancer & Blood Specialists - Eastchester Cancer Care Center Shirley, New York 11967	Active, not recruiting
Southeastern Medical Oncology Center - Goldsboro Goldsboro, North Carolina 27534	Active, not recruiting
USOR - Oncology Hematology Care - West Cincinnati, Ohio 45211	Active, not recruiting
Stephenson Cancer Center Oklahoma City, Oklahoma 73104	Active, not recruiting
Mercy Clinic Oncology and Hematology - Coletta Oklahoma City, Oklahoma 73120	Active, not recruiting
Oklahoma Cancer Specialists and Research Institute (OCSRI) - Tulsa Tulsa, Oklahoma 74146	Active, not recruiting
Allegheny General Hospital Pittsburgh, Pennsylvania 15212	Active, not recruiting
Bon Secours Hematology and Oncology Greenville, South Carolina 29607	Active, not recruiting
Greco-Hainesworth Tennessee Oncology Centers for Research - Chattanooga-Memorial Plaza Chattanooga, Tennessee 37404	Active, not recruiting
Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology Nashville, Tennessee 37203	Active, not recruiting
Dallas Veterans Affairs Medical Center Dallas, Texas 75216	Active, not recruiting
USOR - Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center Dallas, Texas 75246	Active, not recruiting
Oncology Consultants - Texas Medical Center Houston, Texas 77030	Active, not recruiting
University of Texas MD Anderson Cancer Center Houston, Texas 77030	Active, not recruiting
Millennium Physicians - North Houston Houston, Texas 77090	Active, not recruiting
Local Institution - 010-999 Irving, Texas 75063	Active, not recruiting
Texas Oncology - San Antonio Medical Center San Antonio, Texas 78240	Active, not recruiting
Baylor Scott & White Medical Center - Temple Temple, Texas 76508	Active, not recruiting
Texas Oncology - Northeast Texas Cancer and Research Institute - Tyler Tyler, Texas 75702	Active, not recruiting
Utah Cancer Specialists Salt Lake City, Utah 84106	Active, not recruiting
Inova Medical Group - Hematology Oncology - Arlington Fairfax, Virginia 22031-4630	Active, not recruiting
Hematology Oncology Associates of Fredericksburg Fredericksburg, Virginia 24408	Active, not recruiting
Virginia Cancer Institute - West End Richmond, Virginia 23229	Active, not recruiting
Massey Cancer Center Richmond, Virginia 23298	Active, not recruiting
Providence Regional Cancer Partnership Everett, Washington 98201	Active, not recruiting
Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location Seattle, Washington 98109--1023	Active, not recruiting
MultiCare Institute for Research & Innovation Tacoma, Washington 98405	Active, not recruiting
USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Vancouver Cancer Center Vancouver, Washington 98684	Active, not recruiting
West Virginia University Health Sciences Campus Morgantown, West Virginia 26506-9300	Active, not recruiting
Froedtert Clinical Cancer Center Milwaukee, Wisconsin 53226	Active, not recruiting
Argentina
Instituto Medico Especializado Alexander Fleming Buenos Aires C1426ANZ	Active, not recruiting
Hospital de Gastroenterologia Dr. Carlos Bonorino Udaondo Buenos Aires CI264 AAA	Active, not recruiting
CIPREC - Centro de Investigacion y Prevencion Cardiovascular Caba 1061	Active, not recruiting
CORI Centro Oncologico Riojano Integral La Rioja F5300COE	Active, not recruiting
Hospital Nossa Senhora da Conceicao Porto Alegre 91350-200	Active, not recruiting
Clinica Viedma Viedma R8500ACE	Active, not recruiting
Australia
Flinders Medical Centre Bedford Park 5042	Active, not recruiting
Monash Health Clayton 3168	Active, not recruiting
Canberra Region Cancer Centre Garran 2065	Active, not recruiting
Austin Health Heidelberg 3084	Active, not recruiting
The Alfred Melbourne 3004	Active, not recruiting
Calvary Mater Newcastle Hospital Waratah 2298	Active, not recruiting
Austria
Medizinische Universitat Innsbruck Innsbruck 6020	Active, not recruiting
Landesklinikum Wiener Neustadt Wiener Neustadt 2700	Active, not recruiting
Medizinische Universitat Wien Wien 1090	Active, not recruiting
Belgium
Universitair Ziekenhuis Brussel Brussel 1090	Active, not recruiting
Universitair Ziekenhuis Antwerpen Edegem 2650	Active, not recruiting
Universitair Ziekenhuis Gent Gent 9000	Active, not recruiting
Centre Hospitalier Universitaire Universite Catholique de Louvain - Site Godinne Yvoir B-5530	Active, not recruiting
Brazil
ONCOSITE - Centro de Pesquisa Clinica Em Oncologia Ltda. Ijui, Rio Grande Do Sul 98700-000	Active, not recruiting
Hospital de Clinicas de Porto Alegre Porto Alegre, Rio Grande Do Sul 90035-903	Active, not recruiting
Centro de Ensino e Pesquisa da Clinica de Oncologia Reichow Blumenau, Santa Catarina 89010-340	Active, not recruiting
Instituto de Oncologia do Parana - IOP Oncoville Curitiba 80040-170	Active, not recruiting
A.C. Camargo Cancer Center Liberdade 01509-010	Active, not recruiting
CEPHO - Centro de Estudos e Pesquisa de Hematologia e Oncologia Santo Andre 09060-650	Active, not recruiting
Hospital de Base - Sao Jose do Rio Preto Sao Jose do Rio Preto 15090-000	Active, not recruiting
Instituto do Cancer do Estado de Sao Paulo (ICESP) Sao Paolo 01246-000	Active, not recruiting
A Beneficencia Portuguesa de Sao Paulo - Unidade Mirante Sao Paulo 01323-030	Active, not recruiting
OncoStar - Rede Dor Sao Paulo 04543-000	Active, not recruiting
Canada
Ottawa Hospital - General Campus Ottawa, Ontario K1H 8L6	Active, not recruiting
St. Michaels Hospital - Toronto Toronto, Ontario M5B 1W8	Active, not recruiting
Princess Margaret Cancer Centre Toronto, Ontario M5G 2M9	Active, not recruiting
Hopital Maisonneuve-Rosemont Montreal, Quebec H1T 2M4	Active, not recruiting
Colombia
Clinica de la Costa Barranquilla 080020	Active, not recruiting
Instituto Nacional de Cancerologia Bogota 0	Active, not recruiting
Fundacion Oftalmologica de Santander - FOSCAL Floridablanca 0	Active, not recruiting
Hospital Pablo Tobon Uribe Medellin 050034	Active, not recruiting
Czechia
Masarykuv Onkologicky Ustav Brno 656 53	Active, not recruiting
Fakultni Nemocnice u sv. Anny v Brne Brno 656 91	Active, not recruiting
Fakultni Nemocnice Olomouc Olomouc 779 00	Active, not recruiting
Fakultni nemocnice v Motole Praha 5 150 06	Active, not recruiting
Denmark
Rigshospitalet Copenhagen 2100	Active, not recruiting
Odense Universitetshospital Odense 5000	Active, not recruiting
Sygehus Lillebaelt - Vejle Sygehus Vejle 7100	Active, not recruiting
Finland
Helsingin ja Uudenmaan Sairaanhoitopiirin - Syopakeskus Helsinki FI-00029	Active, not recruiting
Tampereen Yliopistollinen Sairaala (TAYS) Tampere 33520	Active, not recruiting
Turun Yliopistollinen Keskussairaala - Kantasairaala Turku 20521	Active, not recruiting
France
Institut Sainte Catherine Avignon Cedex 9 84918	Active, not recruiting
Centre Hospitalier Regional et Universitaire de Besancon - Saint-Jacques Besancon 25000	Active, not recruiting
Institut Bergonie Bordeaux 33000	Active, not recruiting
Hopital Morvan Brest 29200	Active, not recruiting
Centre Georges Francois Leclerc Dijon cedex 21079	Active, not recruiting
Hopital Huriez Lille 59037	Active, not recruiting
Centre Leon Berard Lyon 69008	Active, not recruiting
Hopital de la Timone Marseille Cedex 5 13005	Active, not recruiting
Hopital Saint-Antoine Paris Cedex 12 75012	Active, not recruiting
Hopital Saint-Louis Paris 75010	Active, not recruiting
Hopital Universitaire Pitie Salpetriere Paris 75013	Active, not recruiting
Hopital Europeen Georges-Pompidou Paris 75015	Active, not recruiting
Centre Hospitalier Universitaire de Bordeaux Pessac 33720	Active, not recruiting
Hopital Foch Suresnes 92150	Active, not recruiting
Centre Hospitalier Universitaire de Toulouse Toulouse cedex 9 31059	Active, not recruiting
Hopital Bretonneau Tours Cedex 9 37044	Active, not recruiting
Gustave Roussy Villejuif 94805	Active, not recruiting
Germany
Klinikum St. Marien Amberg Amberg 92224	Active, not recruiting
Charite Campus Mitte (SEE Charite - Universitatsmedizin Berlin) Berlin 10117	Active, not recruiting
Medizinische Universitatsklinik Ruhr-Universitat-Bochum Bochum 44791	Active, not recruiting
Universitatsklinikum Carl Gustav Carus Dresden Dresden 01307	Active, not recruiting
Krankenhaus Nordwest Frankfurt am Main 60488	Active, not recruiting
Facharztzentrum Eppendorf Hamburg D-20249	Active, not recruiting
Marien Hospital Herne - Universitatsklinikum der Ruhr-Universitat Bochum Herne 44625	Active, not recruiting
Kliniken Maria Hilf Monchengladbach 41063	Active, not recruiting
LMU Klinikum - Campus Grohadern Munchen 81377	Active, not recruiting
Munchen Klinik Neuperlach Munchen 81737	Active, not recruiting
Kreiskliniken Reutlingen - Klinikum am Steinenberg Reutlingen 72764	Active, not recruiting
Universitatsklinikum Ulm Ulm 89081	Active, not recruiting
Greece
"General Hospital of Athens "Alexandra"" Athens 11528	Active, not recruiting
Metropolitan General Cholargos 155 62	Active, not recruiting
Local Institution - 010-238 Heraklion 71110	Active, not recruiting
University General Hospital of Larissa Larissa 41110	Active, not recruiting
Euromedica General Clinic - Thessaloniki Thessaloniki 54645	Active, not recruiting
Interbalkan Medical Center of Thessaloniki Thessaloniki 57001	Active, not recruiting
Hong Kong
Humanity & Health Clinical Trial Centre Central 0	Active, not recruiting
Hong Kong Integrated Oncology Centre Hong Kong 0	Active, not recruiting
Ireland
St. Vincents University Hospital Dublin 4	Active, not recruiting
Beaumont Hospital - Dublin Dublin 9	Active, not recruiting
Mater Misericordiae University Hospital Dublin D07 R2WY	Active, not recruiting
Mater Private - Dublin Dublin D07 WKW8	Active, not recruiting
Tallaght University Hospital Dublin D24 NR0A	Active, not recruiting
Italy
Azienda Ospedaliera San Giuseppe Moscati - Avellino Avellino 83100	Active, not recruiting
Azienda Sanitaria Locale di Biella - Nuovo Ospedale degli Infermi Biella 13875	Active, not recruiting
Azienda Ospedaliero - Universitaria di Cagliari Cagliari 9042	Active, not recruiting
Istituto di Candiolo - Fondazione del Piemonte per lOncologia Candiolo 10060	Active, not recruiting
Azienda Unita Sanitaria Locale Toscana Nord Ovest Lido di Camaiore 55041	Active, not recruiting
"Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST" Meldola 47014	Active, not recruiting
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda Milano 20162	Active, not recruiting
Istituto Europeo di Oncologia Milan 20141	Active, not recruiting
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale Napoli 80131	Active, not recruiting
Istituto Oncologico Veneto - IRCCS Padova 35128	Active, not recruiting
Azienda Ospedaliero-Universitaria Pisana Pisa 56126	Active, not recruiting
Azienda Unita Sanitaria Locale di Reggio Emilia Reggio Emilia 42100	Active, not recruiting
Istituto Nazionale Tumori Regina Elena Roma 00144	Active, not recruiting
Azienda Ospedaliera Ordine Mauriziano di Torino Torino 10128	Active, not recruiting
Korea, Republic of
Hallym University Sacred Heart Hospital Anyang-si 14068	Active, not recruiting
Inje University Haeundae Paik Hospital Busan 48108	Active, not recruiting
Dong-A University Hospital Busan 602-812	Active, not recruiting
Chungnam National University Hospital Daejeon 35015	Active, not recruiting
National Cancer Center - Korea Goyang-si 10408	Active, not recruiting
Chonnam National University Hwasun Hospital Hwasun-gun 58128	Active, not recruiting
Cha Bundang Medical Center Seongnam-si 13496	Active, not recruiting
Korea University Anam Hospital Seoul 02841	Active, not recruiting
Seoul National University Hospital Seoul 03080	Active, not recruiting
Asan Medical Center Seoul 05505	Active, not recruiting
Samsung Medical Center Seoul 06351	Active, not recruiting
The Catholic University of Korea - Seoul St. Marys Hospital Seoul 06591	Active, not recruiting
Catholic University of Korea Saint Vincents Hospital Suwon-Si 16247	Active, not recruiting
Pusan National University Yangsan Hospital Yangsan-si 50612	Active, not recruiting
Malaysia
Hospital Sultan Ismail Johor Bahru, Johor 81100	Active, not recruiting
Hospital Wanita Dan Kanak-Kanak Sabah Kota Kinabalu, Sabah 88996	Active, not recruiting
Beacon Hospital Sdn Bhd. Petaling Jaya, Selangor 46050	Active, not recruiting
Hospital Kuala Lumpur Kuala Lumpur 50586	Active, not recruiting
Pusat Perubatan Universiti Malaya Kuala Lumpur 50603	Active, not recruiting
Institut Kanser Negara Putrajaya 62250	Active, not recruiting
Mexico
Centro de Estudio y Prevencion del Cancer Tuxtla Gutierrez, Chiapas 29038	Active, not recruiting
Instituto Nacional de Cancerologia - Mexico Mexico City, Distrito Federal 14080	Active, not recruiting
"Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde"" Guadalajara, Jalisco 44280	Active, not recruiting
Consultores en Oncologia Mexico S. de R.L. de C.V. Guadalajara, Jalisco 44670	Active, not recruiting
PanAmerican Clinical Research Mexico - Cuernavaca Cuernavaca, Morelos 62290	Active, not recruiting
Unidad de Medicina Especializada SMA SC San Juan del Rio, Queretaro 76800	Active, not recruiting
CLIMERS Clinical Medical Research Colonia Centro Orizaba, Veracruz 94300	Active, not recruiting
Netherlands
Antoni Van Leeuwenhoek Ziekenhuis Amsterdam 1066 CX	Active, not recruiting
Amsterdam Universitair Medische Centra (UMC) - Locatie Vrije Universiteit Medisch Centrum Amsterdam 1081 HV	Active, not recruiting
Radboud Universitair Medisch Centrum Nijmegen 6525 GA	Active, not recruiting
St. Antonius Ziekenhuis - Ziekenhuis Nieuwegein Utrecht 3543 AZ	Active, not recruiting
Poland
Copernicus Podmiot Leczniczy - Wojewodzkie Centrum Onkologii Gdansk 80-219	Active, not recruiting
Europejskie Centrum Zdrowia Otwock Otwock 05-400	Active, not recruiting
Centrum Onkologii-Instytut im. Marii Sklodowskiej - Curie - Wawelska Warszawa 02-034	Active, not recruiting
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji (MSWiA) w Warszawie Warszawa 02-507	Active, not recruiting
Portugal
Unidade Local de Saude de Braga, E. P. E (Hospital de Braga) Braga 4710-243	Active, not recruiting
The Champalimaud Centre for the Unknown Lisbon 1400-038	Active, not recruiting
Unidade Local de Saude de Santa Maria, E. P. E. - Hospital de Santa Maria Lisbon 1649-035	Active, not recruiting
Unidade Local de Saude de Santo Antonio, E. P. E - Hospital Geral de Santo Antonio Porto 4099-001	Active, not recruiting
Instituto Portugues de Oncologia do Porto Francisco Gentil Porto 4200-072	Active, not recruiting
Puerto Rico
Hospital Espanol Auxilio Mutuo San Juan 00919	Active, not recruiting
Fundacion de Investigacion de Diego Clinical Research San Juan 00927	Active, not recruiting
PanOncology Trials - Rio Piedras Medical Center San Juan 00935	Active, not recruiting
Romania
Spitalul Jude�ean de Urgen�a dr. Constantin Opri� Baia Mare Baia Mare 430031	Active, not recruiting
Hyperclinica MedLife Policlinica de Diagnostic Rapid Turnului Brasov Brașov 500152	Active, not recruiting
Institutul Clinic Fundeni Bucharest 022328	Active, not recruiting
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca 400015	Active, not recruiting
Medisprof Cluj-Napoca 400641	Active, not recruiting
Centrul de Oncologie Sf Nectarie Craiova 200746	Active, not recruiting
Ovidius Clinical Hospital Ovidiu 905900	Active, not recruiting
SC OncoMed SRL Timisoara 300239	Active, not recruiting
Singapore
National University Hospital - Singapore Singapore 119074	Active, not recruiting
National Cancer Centre Singapore Singapore 168583	Active, not recruiting
Raffles Hospital Singapore 188770	Active, not recruiting
Icon Cancer Centre Farrer Park Singapore 217562	Active, not recruiting
Oncocare Cancer Centre Singapore 258499	Active, not recruiting
Spain
Complejo Hospitalario Universitario A Coruna A Coruna 15006	Active, not recruiting
Hospital Germans Trias i Pujol Badalona 08916	Active, not recruiting
Hospital Universitari Vall dHebron Barcelona 08035	Active, not recruiting
Hospital Clinic de Barcelona Barcelona 08036	Active, not recruiting
Hospital Universitario Reina Sofia Cordoba 14004	Active, not recruiting
Hospital Duran i Reynals LHospitalet de Llobregat 08908	Active, not recruiting
Hospital General Universitario Gregorio Maranon Madrid 28007	Active, not recruiting
Hospital Clinico San Carlos Madrid 28040	Active, not recruiting
Hospital Universitario 12 de Octubre Madrid 28041	Active, not recruiting
Hospital Universitario La Paz Madrid 28046	Active, not recruiting
Clinica Universidad de Navarra - Pamplona Pamplona 31008	Active, not recruiting
Hospital de Sabadell Sabadell 08208	Active, not recruiting
Hospital Universitario Marques de Valdecilla Santander 39008	Active, not recruiting
Hospital Clinico Universitario de Valencia Valencia 46010	Active, not recruiting
Consorci Hospital General Universitari de Valencia Valencia 46014	Active, not recruiting
Taiwan
Changhua Christian Hospital Changhua City 500	Active, not recruiting
Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung 807	Active, not recruiting
Taichung Veterans General Hospital Taichung 40705	Active, not recruiting
Chi Mei Hospital - Liouying Tainan City 73657	Active, not recruiting
National Cheng Kung University Hospital Tainan 704	Active, not recruiting
National Taiwan University Hospital Taipei City 10002	Active, not recruiting
Chang Gung Memorial Hospital - Linkou Branch Taoyuan 333	Active, not recruiting
Thailand
Mahidol University Bang Phlat 10700	Active, not recruiting
Faculty of Medicine Ramathibodi Hospital Bangkok 10400	Active, not recruiting
Maharaj Nakorn Chiang Mai Hospital Chiang Mai 50200	Active, not recruiting
Holistic Center For Cancer Study and Care Hat Yai 90110	Active, not recruiting
King Chulalongkorn Memorial Hospital Khlong Toey 10110	Active, not recruiting
Ukraine
Municipal Non-Profit Enterprise of Sumy Regional Council Sumy Regional Clinical Oncological Dispensary Sumy 40022	Active, not recruiting
United Kingdom
NHS Grampian Aberdeen AB25 2ZN	Active, not recruiting
University Hospital Birmingham NHS Foundation Trust Birmingham B15 2WB	Active, not recruiting
Cambridge University Hospitals NHS Foundation Trust Cambridge CB2 0QQ	Active, not recruiting
University Hospitals Dorset NHS Foundation Trust Dorset BH7 7DW	Active, not recruiting
NHS Greater Glasgow and Clyde Glasgow G12 0XH	Active, not recruiting
Maidstone and Tunbridge Wells NHS Trust Kent ME16 9QQ	Active, not recruiting
Leeds Teaching Hospitals NHS Trust Leeds LS9 7TF	Active, not recruiting
University College London Hospitals NHS Foundation Trust London NW1 2BU	Active, not recruiting
The Royal Marsden NHS Foundation Trust London SW3 6JJ	Active, not recruiting
The Christie NHS Foundation Trust Manchester M20 4BX	Active, not recruiting
East and North Hertfordshire NHS Trust Middlesex HA6 2RN	Active, not recruiting

Inclusion Criteria

Inclusion Criteria:

* Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
* Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria

Exclusion Criteria:

* Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
* Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
* Active brain metastasis

NCT ID

NCT04793958

Date Trial Added

2021-03-11

Updated Date

2024-06-21

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