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Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Program Status

Active, not recruiting

Phase

Phase 3

Immunotherapy-centered Trial

Prior Immunotherapy Allowed

Yes

CRC-directed Trial

Yes

Drugs

cetuximab, FOLFIRI Regimen, mFOLFOX6 Regimen, MRTX849

Tags

MSI-H/ MMRd, MSS/ MMRp

Location	Location Status
United States
Research Site Birmingham, Alabama 35205	Active, not recruiting
Research Site Gilbert, Arizona 85234	Active, not recruiting
Research Site Goodyear, Arizona 85338	Active, not recruiting
Research Site Phoenix, Arizona 85054	Active, not recruiting
Research Site Springdale, Arkansas 72762	Active, not recruiting
Research Site Bakersfield, California 93309	Active, not recruiting
Research Site Clovis, California 93611	Active, not recruiting
Research Site Fullerton, California 92835	Active, not recruiting
Research Site Los Angeles, California 90033	Active, not recruiting
Research Site Los Angeles, California 90048	Active, not recruiting
Research Site Redlands, California 92373	Active, not recruiting
Research Site San Diego, California 92123	Active, not recruiting
Research Site San Francisco, California 94115	Active, not recruiting
Research Site Santa Monica, California 90404	Active, not recruiting
Research Site Sylmar, California 91342	Active, not recruiting
Research Site Torrance, California 90505	Active, not recruiting
Research Site Whittier, California 90602	Active, not recruiting
Research Site Denver, Colorado 80218	Active, not recruiting
Research Site Norwich, Connecticut 06360	Active, not recruiting
Research Site Fort Myers, Florida 33901	Active, not recruiting
Research Site Jacksonville, Florida 32224	Active, not recruiting
Research Site Ocala, Florida 34471	Active, not recruiting
Research Site Orlando, Florida 32804	Active, not recruiting
Research Site Orlando, Florida 32806	Active, not recruiting
Research Site Saint Petersburg, Florida 33705	Active, not recruiting
Research Site Saint Petersburg, Florida 33709	Active, not recruiting
Research Site Tallahassee, Florida 32308	Active, not recruiting
Research Site West Palm Beach, Florida 33401	Active, not recruiting
Research Site Weston, Florida 33331	Active, not recruiting
Research Site Naperville, Illinois 60540	Active, not recruiting
Research Site Zion, Illinois 60099	Active, not recruiting
Research Site Indianapolis, Indiana 46237	Active, not recruiting
Research Site Iowa City, Iowa 52242	Active, not recruiting
Research Site Baton Rouge, Louisiana 70809	Active, not recruiting
Research Site Baltimore, Maryland 21201	Active, not recruiting
Research Site Boston, Massachusetts 02114	Active, not recruiting
Research Site Detroit, Michigan 48202	Active, not recruiting
Research Site Minneapolis, Minnesota 55404	Active, not recruiting
Research Site Rochester, Minnesota 55905	Active, not recruiting
Research Site Saint Paul, Minnesota 55101	Active, not recruiting
Research Site Springfield, Missouri 65804	Active, not recruiting
Research Site Lincoln, Nebraska 68510	Active, not recruiting
Research Site Omaha, Nebraska 68130	Active, not recruiting
Research Site Las Vegas, Nevada 89169	Active, not recruiting
Research Site Belleville, New Jersey 07109	Active, not recruiting
Research Site Florham Park, New Jersey 07932	Active, not recruiting
Research Site New Brunswick, New Jersey 08903	Active, not recruiting
Research Site Somerset, New Jersey 08873-5002	Active, not recruiting
Research Site New York, New York 10016	Active, not recruiting
Research Site New York, New York 10029	Active, not recruiting
Research Site New York, New York 10065	Active, not recruiting
Research Site Port Jefferson Station, New York 11776	Active, not recruiting
Research Site Jacksonville, North Carolina 28546	Active, not recruiting
Research Site Sparta, North Carolina 28675	Active, not recruiting
Research Site Cincinnati, Ohio 45211	Active, not recruiting
Research Site Oklahoma City, Oklahoma 73104	Active, not recruiting
Research Site Oklahoma City, Oklahoma 73120	Active, not recruiting
Research Site Tulsa, Oklahoma 74146	Active, not recruiting
Research Site Chattanooga, Tennessee 37404	Active, not recruiting
Research Site Nashville, Tennessee 37203	Active, not recruiting
Research Site Dallas, Texas 75216	Active, not recruiting
Research Site Dallas, Texas 75246	Active, not recruiting
Research Site Houston, Texas 77030	Active, not recruiting
Research Site Houston, Texas 77090	Active, not recruiting
Research Site Longview, Texas 75601	Active, not recruiting
Research Site San Antonio, Texas 78240	Active, not recruiting
Research Site Temple, Texas 76508	Active, not recruiting
Research Site Salt Lake City, Utah 84106	Active, not recruiting
Research Site Fairfax, Virginia 22031	Active, not recruiting
Research Site Fredericksburg, Virginia 24408	Active, not recruiting
Research Site Richmond, Virginia 23230	Active, not recruiting
Research Site Richmond, Virginia 23298	Active, not recruiting
Research Site Everett, Washington 98201	Active, not recruiting
Research Site Seattle, Washington 98109	Active, not recruiting
Research Site Tacoma, Washington 98405	Active, not recruiting
Research Site Vancouver, Washington 98684	Active, not recruiting
Research Site Morgantown, West Virginia 26506	Active, not recruiting
Research Site Milwaukee, Wisconsin 53226	Active, not recruiting
Argentina
Research Site Viedma, Rio Negro R8500ACE	Active, not recruiting
Research Site Buenos Aires C1061AAS	Active, not recruiting
Research Site Buenos Aires C1426ANZ	Active, not recruiting
Research Site Buenos Aires CI264 AAA	Active, not recruiting
Research Site La Rioja F5300COE	Active, not recruiting
Australia
Research Site Waratah, New South Wales 2298	Active, not recruiting
Research Site Bedford Park, South Australia 5042	Active, not recruiting
Research Site Clayton, Victoria 3168	Active, not recruiting
Research Site Heidelberg, Victoria 3084	Active, not recruiting
Research Site Melbourne, Victoria 3004	Active, not recruiting
Research Site Garran 2605	Active, not recruiting
Austria
Research Site Innsbruck, Tyrol 6020	Active, not recruiting
Research Site Wiener Neustadt 2700	Active, not recruiting
Research Site Wien 1090	Active, not recruiting
Belgium
Research Site Edegem, Antwerpen 2650	Active, not recruiting
Research Site Brussels 1090	Active, not recruiting
Research Site Gent 9000	Active, not recruiting
Research Site Yvoir 5530	Active, not recruiting
Brazil
Research Site Porto Alegre, Rio Grande Do Sul 90035-903	Active, not recruiting
Research Site Porto Alegre, Rio Grande Do Sul 91350-200	Active, not recruiting
Research Site Blumenau, Santa Catarina 89010-340	Active, not recruiting
Research Site Curitiba 80520-174	Active, not recruiting
Research Site Ijuí 98700-000	Active, not recruiting
Research Site Sao Paulo 01509-010	Active, not recruiting
Research Site São Paulo 01246	Active, not recruiting
Research Site São Paulo 01323-030	Active, not recruiting
Research Site São Paulo 04543-000	Active, not recruiting
Research Site São Paulo 09060-650	Active, not recruiting
Research Site São Paulo 15090-000	Active, not recruiting
Canada
Research Site Ottawa, Ontario K1H 8L6	Active, not recruiting
Research Site Toronto, Ontario M5B 1W8	Active, not recruiting
Research Site Montréal, Quebec H1T 2M4	Active, not recruiting
Research Site Toronto M5G 2M9	Active, not recruiting
China
Research Site Bengbu, Anhui 233004	Active, not recruiting
Research Site Hefei, Anhui 230031	Active, not recruiting
Research Site Hefei, Anhui 230088	Active, not recruiting
Research Site Fuzhou, Fujian 350014	Active, not recruiting
Research Site Guangzhou, Guang Dong 510655	Active, not recruiting
Research Site Shenzhen, Guang Dong 518036	Active, not recruiting
Research Site Nanning, Guangxi 530000	Active, not recruiting
Research Site Harbin, Heilongjiang 150081	Active, not recruiting
Research Site Zhengzhou, Henan	Active, not recruiting
Research Site Wuhan, Hubei	Active, not recruiting
Research Site Changsha, Hunan 410008	Active, not recruiting
Research Site Changsha, Hunan 410013	Active, not recruiting
Research Site Nanjing, Jiangsu 210029	Active, not recruiting
Research Site Wuxi, Jiangsu 214400	Active, not recruiting
Research Site Nanchang, Jiangxi	Active, not recruiting
Research Site Changchun, Jilin 130000	Active, not recruiting
Research Site Changchun, Jilin 130015	Active, not recruiting
Research Site Shenyang, Liaoning 110042	Active, not recruiting
Research Site Shenyang, Liaoning 110101	Active, not recruiting
Research Site Shanghai, Pudong 201321	Active, not recruiting
Research Site Jinan, Shandong 250117	Active, not recruiting
Research Site Chengdu, Sichuan 610041	Active, not recruiting
Research Site Neijiang, Sichuan 641100	Active, not recruiting
Research Site Hangzhou, Zhejiang 310017	Active, not recruiting
Research Site Hangzhou, Zhejiang 310022	Active, not recruiting
Research Site Beijing 100021	Active, not recruiting
Research Site Beijing 100142	Active, not recruiting
Research Site Shanghai 200025	Active, not recruiting
Research Site Shanghai 200032	Active, not recruiting
Research Site Shanghai 200123	Active, not recruiting
Research Site Shanghai 201620	Active, not recruiting
Research Site Tianjin 300060	Active, not recruiting
Research Site Xi'an 710068	Active, not recruiting
Colombia
Research Site Floridablanca, Santander 681001	Active, not recruiting
Research Site Barranquilla 080020	Active, not recruiting
Research Site Bogotá 111511-110411001	Active, not recruiting
Research Site Medellín 050034	Active, not recruiting
Czechia
Research Site Praha, Prague 150 06	Active, not recruiting
Research Site Brno, South Moravian 656 53	Active, not recruiting
Research Site Brno, South Moravian 656 91	Active, not recruiting
Research Site Olomouc 779 00	Active, not recruiting
Research Site Prague 128 08	Active, not recruiting
Denmark
Research Site Copenhagen 2100	Active, not recruiting
Research Site Odense DK 5000	Active, not recruiting
Research Site Vejle 7100	Active, not recruiting
Finland
Research Site Helsinki 00290	Active, not recruiting
Research Site Tampere 33520	Active, not recruiting
Research Site Turku 20520	Active, not recruiting
France
Research Site Dijon, Bourgogne 21079	Active, not recruiting
Research Site Brest, Bretagne 29200	Active, not recruiting
Research Site Besançon, Doubs 25000	Active, not recruiting
Research Site Lille, Hauts-de-France 59037	Active, not recruiting
Research Site Paris, Ile-de-France 75015	Active, not recruiting
Research Site Toulouse, Midi-Pyrenees 31059	Active, not recruiting
Research Site Avignon, Provence Alpes Cote d'Azure 84918	Active, not recruiting
Research Site Lyon, Rhone-Alpes 69008	Active, not recruiting
Research Site Bourdeaux, Rhone 33000	Active, not recruiting
Research Site Villejuif, Val-de-Marne 94805	Active, not recruiting
Research Site Marseille 13005	Active, not recruiting
Research Site Paris 75010	Active, not recruiting
Research Site Paris 75012	Active, not recruiting
Research Site Paris 75013	Active, not recruiting
Research Site Pessac 33720	Active, not recruiting
Research Site Suresnes 92150	Active, not recruiting
Research Site Tours 37044	Active, not recruiting
Germany
Research Site Ulm, Baden-Wuerttemberg 89081	Active, not recruiting
Research Site Reutlingen, Baden-Wurttemberg	Active, not recruiting
Research Site München, Bayern 81737	Active, not recruiting
Research Site Frankfurt, Hessen 60488	Active, not recruiting
Research Site Bochum, Nordrhein-Westfalen 44791	Active, not recruiting
Research Site Dresden, Sachsen 01307	Active, not recruiting
Research Site Amberg 92224	Active, not recruiting
Research Site Berlin 10117	Active, not recruiting
Research Site Hamburg 20246	Active, not recruiting
Research Site Herne 44625	Active, not recruiting
Research Site Monchengladbach 41063	Active, not recruiting
Research Site München 81377	Active, not recruiting
Greece
Research Site Larissa, Thessaly 41110	Active, not recruiting
Research Site Athens 11528	Active, not recruiting
Research Site Athens 15562	Active, not recruiting
Research Site Heraklion 71110	Active, not recruiting
Research Site Thessaloniki 54645	Active, not recruiting
Research Site Thessaloníki 57001	Active, not recruiting
Hong Kong
Research Site Central 1401-02	Active, not recruiting
Research Site Hong Kong	Active, not recruiting
Ireland
Research Site Dublin D04 Y8V0	Active, not recruiting
Research Site Dublin D07 R2WY	Active, not recruiting
Research Site Dublin D09V2N0	Active, not recruiting
Research Site Dublin D24 NR0A	Active, not recruiting
Italy
Research Site Lido Di Camaiore, Lucca 55041	Active, not recruiting
Research Site Candiolo, Torino 10060	Active, not recruiting
Research Site Avellino 81300	Active, not recruiting
Research Site Biella 13875	Active, not recruiting
Research Site Cagliari 9042	Active, not recruiting
Research Site Meldola 47014	Active, not recruiting
Research Site Milano 20162	Active, not recruiting
Research Site Milan 20141	Active, not recruiting
Research Site Naples 80131	Active, not recruiting
Research Site Padova 35128	Active, not recruiting
Research Site Pisa 56126	Active, not recruiting
Research Site Reggio Emilia 42100	Active, not recruiting
Research Site Roma 00144	Active, not recruiting
Research Site Turin 10128	Active, not recruiting
Korea, Republic of
Research Site Anyang-si, Gyeonggi-do 14068	Active, not recruiting
Research Site Seongnam-si, Gyeonggi-do 13496	Active, not recruiting
Research Site Yangsan, Gyeongsangnam 50612	Active, not recruiting
Research Site Hwasun, Jeollanam-do 58128	Active, not recruiting
Research Site Busan 48108	Active, not recruiting
Research Site Busan 49201	Active, not recruiting
Research Site Daejeon 35015	Active, not recruiting
Research Site Goyang-si 10408	Active, not recruiting
Research Site Seoul 02841	Active, not recruiting
Research Site Seoul 03080	Active, not recruiting
Research Site Seoul 037722	Active, not recruiting
Research Site Seoul 05505	Active, not recruiting
Research Site Seoul 06351	Active, not recruiting
Research Site Seoul 06591	Active, not recruiting
Research Site Sŏwŏn 16247	Active, not recruiting
Malaysia
Research Site Kota Kinabalu, Sabah 88996	Active, not recruiting
Research Site Kuala Lumpur, Selangor 50586	Active, not recruiting
Research Site Kuala Lumpur, Selangor 59100	Active, not recruiting
Research Site Petaling Jaya, Selangor 46050	Active, not recruiting
Research Site Johor Bahru 81100	Active, not recruiting
Research Site Putrajaya 62250	Active, not recruiting
Mexico
Research Site Tuxtla Gutiérrez, Chiapas 29038	Active, not recruiting
Research Site Guadalajara, Jalisco 44280	Active, not recruiting
Research Site Guadalajara, Jalisco 44670	Active, not recruiting
Research Site Cuernavaca, Morelos 62290	Active, not recruiting
Research Site San Juan Del Río, Queretaro 76800	Active, not recruiting
Research Site Mexico City 14080	Active, not recruiting
Research Site Veracruz 94300	Active, not recruiting
Netherlands
Research Site Nijmegen, Gelderland 6525 GA	Active, not recruiting
Research Site Amsterdam, Noor-Holland 1081	Active, not recruiting
Research Site Amsterdam, Noord-Holland 1066 CX	Active, not recruiting
Research Site Nieuwegein, Utrecht 3435 CM	Active, not recruiting
Poland
Research Site Gdańsk 80-219	Active, not recruiting
Research Site Otwock 05-400	Active, not recruiting
Research Site Warsaw 02-034	Active, not recruiting
Research Site Warsaw 02-507	Active, not recruiting
Portugal
Research Site Braga 4710-243	Active, not recruiting
Research Site Lisboa 1400-038	Active, not recruiting
Research Site Lisbon 1649-035	Active, not recruiting
Research Site Porto 4099-001	Active, not recruiting
Research Site Porto 4200-072	Active, not recruiting
Puerto Rico
Research Site San Juan 00935	Active, not recruiting
Research Site San Juan	Active, not recruiting
Romania
Research Site Ovidiu, Constanta 905900	Active, not recruiting
Research Site Baia Mare 430031	Active, not recruiting
Research Site Braşov 500152	Active, not recruiting
Research Site Bucuresti 022328	Active, not recruiting
Research Site Cluj-Napoca 400015	Active, not recruiting
Research Site Cluj-Napoca 400641	Active, not recruiting
Research Site Craiova 200746	Active, not recruiting
Research Site Timişoara 300239	Active, not recruiting
Singapore
Research Site Singapore 119074	Active, not recruiting
Research Site Singapore 169610	Active, not recruiting
Research Site Singapore 188770	Active, not recruiting
Research Site Singapore 217562	Active, not recruiting
Research Site Singapore 258499	Active, not recruiting
Spain
Research Site Badalona, Barcelona 08916	Active, not recruiting
Research Site A Coruña 15006	Active, not recruiting
Research Site Barcelona 08035	Active, not recruiting
Research Site Barcelona 08036	Active, not recruiting
Research Site Barcelona 08908	Active, not recruiting
Research Site Córdoba 14004	Active, not recruiting
Research Site Madrid 28007	Active, not recruiting
Research Site Madrid 28040	Active, not recruiting
Research Site Madrid 28041	Active, not recruiting
Research Site Madrid 28046	Active, not recruiting
Research Site Pamplona 31008	Active, not recruiting
Research Site Sabadell 08208	Active, not recruiting
Research Site Santander 39008	Active, not recruiting
Research Site Valencia 46010	Active, not recruiting
Research Site Valencia 46014	Active, not recruiting
Taiwan
Research Site Changhua 500	Active, not recruiting
Research Site Kaohsiung 807	Active, not recruiting
Research Site Taichung 407	Active, not recruiting
Research Site Tainan 704	Active, not recruiting
Research Site Tainan 736	Active, not recruiting
Research Site Taipei 100	Active, not recruiting
Research Site Taoyuan 333	Active, not recruiting
Thailand
Research Site Bangkok 10110	Active, not recruiting
Research Site Bangkok 10400	Active, not recruiting
Research Site Bangkok 10700	Active, not recruiting
Research Site Chiang Mai 50200	Active, not recruiting
Research Site Hat Yai 90110	Active, not recruiting
United Kingdom
Research Site Bournemouth, Dorset BH7 7DW	Active, not recruiting
Research Site Birmingham, England B91 2PP	Active, not recruiting
Research Site Cambridge, England CB2 0QQ	Active, not recruiting
Research Site Leeds, England LS9 7TF	Active, not recruiting
Research Site London, England NW1 2BD	Active, not recruiting
Research Site London, England SW3 6JJ	Active, not recruiting
Research Site Maidstone, England ME16 9QQ	Active, not recruiting
Research Site Manchester, England M20 4BX	Active, not recruiting
Research Site Middlesex, England HA6 2RN	Active, not recruiting
Research Site Sutton, England SM2 5PT	Active, not recruiting
Research Site Aberdeen, Scotland AB25 2ZN	Active, not recruiting
Research Site Glasgow, Scotland G12 0YN	Active, not recruiting

Inclusion Criteria

Inclusion Criteria:

Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria

Exclusion Criteria:

Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
Active brain metastasis

NCT ID

NCT04793958

Date Trial Added

2021-03-11

Updated Date

2024-03-15

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