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Clinical Trial Finder

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Program Status

Recruiting

Phase

Phase 3

Immunotherapy-centered Trial

No

Prior Immunotherapy Allowed

Yes

CRC-directed Trial

Yes

Drugs

cetuximab, FOLFIRI Regimen, mFOLFOX6 Regimen, MRTX849

Tags

MSS/ pMMR
Location Location Status
United States
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Birmingham, Alabama 35205
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Gilbert, Arizona 85234
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Goodyear, Arizona 85338
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Phoenix, Arizona 85054
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Springdale, Arkansas 72762
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Bakersfield, California 93309
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Clovis, California 93611
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Fullerton, California 92835
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Los Angeles, California 90033
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Los Angeles, California 90048
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Redlands, California 92373
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San Diego, California 92123
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San Francisco, California 94115
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Sylmar, California 91342
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Torrance, California 90505
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Whittier, California 90602
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Aurora, Colorado 80045
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Denver, Colorado 80218
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Norwich, Connecticut 06360
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Fort Myers, Florida 33901
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Jacksonville, Florida 32224
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Miami, Florida 33136
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Ocala, Florida 34471
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Orlando, Florida 32804
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Orlando, Florida 32806
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Saint Petersburg, Florida 33705
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Saint Petersburg, Florida 33709
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Tallahassee, Florida 32308
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West Palm Beach, Florida 33401
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Weston, Florida 33331
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Atlanta, Georgia 30322
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Newnan, Georgia 30265
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Naperville, Illinois 60540
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Zion, Illinois 60099
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Iowa City, Iowa 52242
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Baton Rouge, Louisiana 70809
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Baltimore, Maryland 21201
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Boston, Massachusetts 02114
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Detroit, Michigan 48202
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Minneapolis, Minnesota 55404
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Rochester, Minnesota 55905
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Saint Paul, Minnesota 55101
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Springfield, Missouri 65804
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Lincoln, Nebraska 68510
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Las Vegas, Nevada 89169
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Belleville, New Jersey 07109
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Florham Park, New Jersey 07932
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New Brunswick, New Jersey 08903
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Somerset, New Jersey 08873-5002
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New York, New York 10016
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New York, New York 10029
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New York, New York 10065
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Port Jefferson Station, New York 11776
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Jacksonville, North Carolina 28546
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Sparta, North Carolina 28675
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Oklahoma City, Oklahoma 73104
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Tulsa, Oklahoma 74146
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Greenville, South Carolina 29607
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Chattanooga, Tennessee 37404
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Nashville, Tennessee 37203
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Dallas, Texas 75216
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Dallas, Texas 75246
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Houston, Texas 77030
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Houston, Texas 77090
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Longview, Texas 75601
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Temple, Texas 76508
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Salt Lake City, Utah 84106
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Fairfax, Virginia 22031
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Fredericksburg, Virginia 24408
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Richmond, Virginia 23230
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Richmond, Virginia 23298
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Everett, Washington 98201
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Seattle, Washington 98109
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Tacoma, Washington 98405
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Vancouver, Washington 98684
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Milwaukee, Wisconsin 53226
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Argentina
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Viedma, Rio Negro R8500ACE
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Buenos Aires C1426ANZ
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La Rioja F5300COE
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Australia
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Waratah, New South Wales 2298
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Bedford Park, South Australia 5042
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Clayton, Victoria 3168
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Heidelberg, Victoria 3084
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Melbourne, Victoria 3004
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Austria
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Innsbruck, Tyrol 6020
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Wiener Neustadt 2700
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Wien 1090
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Belgium
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Edegem, Antwerpen 2650
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Brussels 1090
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Gent 9000
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Yvoir 5530
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Canada
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Ottawa, Ontario K1H 8L6
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Toronto, Ontario M5B 1W8
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Montréal, Quebec H1T 2M4
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Toronto M5G 2M9
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China
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Hefei, Anhui 230031
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Zhengzhou, Henan
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Wuhan, Hubei
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Nanchang, Jiangxi
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Jinan, Shandong 250117
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Beijing 100142
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Czechia
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Praha, Prague 150 06
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Brno, South Moravian 656 53
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Brno, South Moravian 656 91
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Olomouc 779 00
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Prague 128 08
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Denmark
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Copenhagen 2100
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Vejle 7100
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Finland
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Helsinki 00290
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Tampere 33520
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Turku 20520
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France
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Dijon, Bourgogne 21079
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Brest, Bretagne 29200
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Besançon, Doubs 25000
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Lille, Hauts-de-France 59037
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Paris, Ile-de-France 75015
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Toulouse, Midi-Pyrenees 31059
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Avignon, Provence Alpes Cote d'Azure 84918
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Lyon, Rhone-Alpes 69008
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Bourdeaux, Rhone 33000
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Villejuif, Val-de-Marne 94805
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Marseille 13005
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Paris 75010
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Paris 75012
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Paris 75013
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Pessac 33720
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Suresnes 92150
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Tours 37044
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Germany
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Reutlingen, Baden-Wurttemberg
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München, Bayern 81737
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Frankfurt, Hessen 60488
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Bochum, Nordrhein-Westfalen 44791
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Dresden, Sachsen 01307
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Herne 44625
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Monchengladbach 41063
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München 81377
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Greece
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Larissa, Thessaly 41110
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Athens 11528
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Athens 15562
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Heraklion 71110
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Thessaloniki 54645
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Thessaloníki 57001
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Hong Kong
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Hong Kong
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Ireland
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Dublin D04 Y8V0
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Dublin D24 NR0A
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Italy
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Lido Di Camaiore, Lucca 55041
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Candiolo, Torino 10060
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Avellino 81300
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Biella 13875
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Cagliari 9042
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Milano 20162
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Milan 20141
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Naples 80131
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Padova 35128
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Pisa 56126
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Reggio Emilia 42100
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Roma 00144
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Turin 10128
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Korea, Republic of
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Anyang-si, Gyeonggi-do 14068
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Seongnam-si, Gyeonggi-do 13496
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Hwasun, Jeollanam-do 58128
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Busan 48108
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Busan 49201
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Goyang-si 10408
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Seoul 02841
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Seoul 03080
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Seoul 037722
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Seoul 05505
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Seoul 06351
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Sŏwŏn 16247
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Malaysia
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Kuala Lumpur, Selangor 50586
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Kuala Lumpur, Selangor 59100
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Petaling Jaya, Selangor 46050
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Johor Bahru 81100
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Putrajaya 62250
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Mexico
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Tuxtla Gutiérrez, Chiapas 29038
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Guadalajara, Jalisco 44280
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San Juan Del Río, Queretaro 76800
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Veracruz 94300
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Netherlands
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Nijmegen, Gelderland 6525 GA
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Amsterdam, Noord-Holland 1066 CX
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Poland
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Gdańsk 80-219
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Otwock 05-400
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Warsaw 02-034
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Portugal
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Braga 4710-243
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Lisboa 1400-038
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Lisbon 1649-035
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Porto 4099-001
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Puerto Rico
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San Juan 00935
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San Juan
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Singapore
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Singapore 119074
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Singapore 169610
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Singapore 217562
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Singapore 258499
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Spain
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Badalona, Barcelona 08916
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A Coruña 15006
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Barcelona 08035
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Barcelona 08036
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Barcelona 08908
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Córdoba 14004
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Madrid 28007
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Madrid 28040
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Madrid 28041
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Madrid 28046
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Pamplona 31008
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Sabadell 08208
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Santander 39008
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Valencia 46010
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Valencia 46014
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Taiwan
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Kaohsiung 807
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Taichung 407
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Tainan 704
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Tainan 736
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Taipei 100
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Taoyuan 333
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Thailand
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Bangkok 10700
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Chiang Mai 50200
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United Kingdom
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Bournemouth, Dorset BH7 7DW
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Birmingham, England B91 2PP
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Cambridge, England CB2 0QQ
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Leeds, England LS9 7TF
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London, England NW1 2BD
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Manchester, England M20 4BX
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Aberdeen, Scotland AB25 2ZN
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Contacts

Mirati Therapeutics Study Locator Services
Contact
1-844-893-5530 miratistudylocator@emergingmed.com

Inclusion Criteria

Inclusion Criteria:

Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria

Exclusion Criteria:

Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
Active brain metastasis

NCT ID

NCT04793958

Date Trial Added

2021-03-11

Updated Date

2022-09-16