Program Status
RecruitingPhase
Phase 1/Phase 2Prior Immunotherapy Allowed
NoCRC-directed Trial
NoDrugs
ROBO1 CAR-NK cellsTags
MSI-H/ MMRd, MSS/ MMRp| Location | Location Status |
|---|---|
| China | |
|
Radiation Therapy Department, Suzhou Cancer Center, Suzhou Hospital Affiliated to Nanjing Medical University Suzhou, Jiangsu 215001 |
Recruiting |
Contacts
Inclusion Criteria
Inclusion Criteria:
Age 18 ~ 75 years old, male or female
Life expectancy ≥ 6 months
ECOG score: 0 - 3
ROBO1 expression in malignancy tissues detected by immuno-histochemistry (IHC)
Advanced solid tumor was diagnosed by pathological or clinical physicians
Laboratory examination: white blood cell ≥ 3 x 10*9/L, blood platelet count ≥ 60 x 10*/L, hemoglobin ≥ 85g/L; lymphocyte count ≥ 15%, total bilirubin ≤ 100 mol/L; ALT and AST less than five times of the normal level; serum creatinine less than 1.5 times of the normal level
Signed informed consent
Women of child-bearing age must have evidence of negative pregnancy test and be willing to practice birth control after 2 weeks following the cell transfusion
Exclusion Criteria
Exclusion Criteria:
Expected overall survival Class II, NYHA), or myocardial infarction within 6 months
Abnormal lung function: FEV (forced expiratory volume) < 30% prediction, DLCO (diffusing capacity of the lung for carbon monoxide) < 30% prediction, blood oxygen saturation < 90%
Other serious diseases: nervous, mental disorders, immune regulatory diseases, metabolic diseases, infectious diseases, etc.
Unable or unwilling to provide informed consent, or fail to comply with the test requirements
