Annual Colonoscopy for Lynch Syndrome

Annual colonoscopies for people with Lynch syndrome (HNPCC or hereditary nonpolyposis colon cancer) successfully find cancers at an early stage. A recent study by the German HNPCC Consortium confirmed the effectiveness of annual colonoscopies to find colorectal cancers at a curable stage.  Regular colonoscopies found early cancers more often than did patient symptoms. Current recommendations are…  Read More

Old Chemo Drug May Fight Lynch Syndrome

Methotrexate, a chemotherapy drug used as long ago as the 1940’s, may be effective against colorectal cancers caused by mutations in a gene that is part of Lynch syndrome. The drug targeted and destroyed cells that contained mutated MSH2 genes. Inherited mutations in MSH2 prevent mistakes in correct copying of DNA during cell division allowing cancer…  Read More

Lynch syndrome: Lifetime Risk of Colorectal and Endometrial Cancers

A new study estimates the lifetime risks for colorectal and endometrial cancer in people with a genetic mutation for Lynch syndrome. The analysis was controlled to avoid bias and overestimating risk. Even after adjusting for possible bias, lifetime risks for both cancers was high and the need for special surveillance was critical.

Running to Raise Lynch Syndrome Awareness

Selena Martinez ran the Santa Cruz Half Marathon on April 19th to raise awareness of Lynch syndrome, or hereditary non-polyposis colon cancer (HNPCC), a genetic condition that greatly increases risk for colorectal and other cancers. The Santa Cruz was the third of eight half marathons, Martinez plans to run to honor of eight members of her family…  Read More

Lynch Syndrome Children Diagnosed Earlier than Their Parents

In inherited medical conditions, anticipation refers to situations where children develop inherited diseases earlier than their parents.  Anticipation appears to be at work in Lynch syndrome with children being diagnosed with cancer an average of 10 years earlier than their affected parent.

Finding Polyps Missed During Colonoscopies for Lynch Syndrome

Lynch syndrome (also known as hereditary nonpolyposis colon cancer) greatly increases the risk for colon and rectal cancer. People with the gene have about an 8 in 10 chance of getting colon cancer during their lives. Because Lynch cancers develop quickly and grow rapidly, it’s important to monitor people who carry the genes closely with colonoscopy…  Read More