Tag Archives: HNPCC

Annual Colonoscopy for Lynch Syndrome

Annual colonoscopies for people with Lynch syndrome (HNPCC or hereditary nonpolyposis colon cancer) successfully find cancers at an early stage. A recent study by the German HNPCC Consortium confirmed the effectiveness of annual colonoscopies to find colorectal cancers at a curable stage.  Regular colonoscopies found early cancers more often than did patient symptoms. Current recommendations are for surveillance colonoscopies to begin by age 25, be repeated every 1 to 2 years until age 40, and then annually.

Old Chemo Drug May Fight Lynch Syndrome

Methotrexate, a chemotherapy drug used as long ago as the 1940′s, may be effective against colorectal cancers caused by mutations in a gene that is part of Lynch syndrome. The drug targeted and destroyed cells that contained mutated MSH2 genes. Inherited mutations in MSH2 prevent mistakes in correct copying of DNA during cell division allowing cancer to develop and grow, particularly inherited colorectal and endometrial cancers.  In addition, MSH2 mutations can occur in some colorectal cancers that are not inherited. Based on the work done in cancer cells, a Phase II clinical trial has begun recruiting patients with advanced colorectal cancer at the Royal Marsden Cancer Hospital in the United

Lynch syndrome: Lifetime Risk of Colorectal and Endometrial Cancers

A new study estimates the lifetime risks for colorectal and endometrial cancer in people with a genetic mutation for Lynch syndrome. The analysis was controlled to avoid bias and overestimating risk. Even after adjusting for possible bias, lifetime risks for both cancers was high and the need for special surveillance was critical.

Running to Raise Lynch Syndrome Awareness

Selena Martinez ran the Santa Cruz Half Marathon on April 19th to raise awareness of Lynch syndrome, or hereditary non-polyposis colon cancer (HNPCC), a genetic condition that greatly increases risk for colorectal and other cancers. The Santa Cruz was the third of eight half marathons, Martinez plans to run to honor of eight members of her family diagnosed with Lynch syndrome cancers.  Sunday’s race was for her sister Noemi Garza who survived colon and endometrial cancer. Martinez’ website Detect the Mutation provides information about recognizing and testing for Lynch syndrome. She is also raising funds for the University of California at San Francisco’s Gastrointestinal Cancer Prevention Program, which offers screenings to those in

Finding Polyps Missed During Colonoscopies for Lynch Syndrome

Lynch syndrome (also known as hereditary nonpolyposis colon cancer) greatly increases the risk for colon and rectal cancer. People with the gene have about an 8 in 10 chance of getting colon cancer during their lives. Because Lynch cancers develop quickly and grow rapidly, it’s important to monitor people who carry the genes closely with colonoscopy every year or two. When doctors in four research centers immediately followed up Lynch syndrome patients after a regular colonoscopy with more intense colonoscopy scrutiny, they discovered they had missed more polyps than they found.  During the first exam, their miss rate for adenomas, polyps with the greatest risk of developing into cancer, was

Lynch Syndrome Colon Cancers Show Better Survival

A new study finds colorectal cancer patients with Lynch syndrome (hereditary non-polyposis colon cancer or HNPCC) have better survival than patients without the inherited form of the disease.  Overall, 94 percent of Lynch syndrome patients were alive five years after their diagnosis compared to 75 percent of those with sporadic cancer.

September is National Ovarian Cancer Awareness Month

In 2008 nearly 22,000 women will be diagnosed with ovarian cancer and more than 15,500 will die. Sometimes called the disease that whispers, ovarian cancer symptoms are often not recognized until its late stages when it is most deadly.  Found early, ovarian cancer is 90 percent curable but most cases are found after the cancer is already advanced. President Bush has proclaimed September 2008 ass National Ovarian Cancer Awareness Month.  During September, advocates will be working to raise awareness of ovarian cancer, let women know about its symptoms, and work toward early detection and effective treatment.

Early Onset Endometrial Cancer Signals Lynch Syndrome

Women who were diagnosed with endometrial cancer under the age of 50 had tumors with signs of Lynch syndrome in a significant number of cases.  Lynch syndrome or hereditary non-polyposis colon cancer (HNPCC) greatly increases the lifetime risk of both colorectal and endometrial cancer. Researchers in Australia studied tumors from 146 women who were diagnosed with endometrial cancer before the age of 51.  They stained the tumor sections for proteins expression by mismatch repair genes, a genetic mutation that leads to Lynch syndrome cancers.  They also tested tumor DNA for other changes that can identify or exclude Lynch syndrome, and reviewed family medical history where it was available. They found