Tag Archives: inherited colorectal cancer

Does Colorectal Cancer Run in Your Family?

Miss last week’s webinar?  It’s right here. Listen to Dr. Henry Lynch talk about his early experience with families with unusually high numbers of colorectal and other cancers.  Hear what he has to say about finding families at risk and preventing cancer deaths. Lynch syndrome survivor, Kate Murphy, shares her own story and that of her family.

Thanksgiving is National Family History Day

Today while you’re digesting turkey or washing the Thanksgiving dinner dishes, take time to talk about your family’s health history.  Steven K. Galson, M.D., M.P.H., the acting Surgeon General, has declared Thanksgiving 2008 the fifth annual National Family History Day. Families are encouraged to share health information to identify diseases that might be inherited or lifestyles that may contribute to medical problems.  Family histories can lead to a discussion with your doctor about tests you may need or changes you should make to prevent cancer and other diseases. My Family Health History, a tool developed by the Surgeon General, can help you make a drawing of your family tree and

Gene Variation Reduces Colorectal Cancer Risk

People with a variation in the gene that controls how fat is metabolized by cells have a lowered chance of getting colorectal cancer, even in families with already increased risk. Scientists studied differences in short regions of the ADIPOQ gene called single nucleotide polymorphisms (SNPs) among patients with colorectal cancer and a similar group of people who didn’t have cancer. In two different study groups, they found that one variation reduced risk of getting cancer by about 30 percent.

Lynch Syndrome Colon Cancers Show Better Survival

A new study finds colorectal cancer patients with Lynch syndrome (hereditary non-polyposis colon cancer or HNPCC) have better survival than patients without the inherited form of the disease.  Overall, 94 percent of Lynch syndrome patients were alive five years after their diagnosis compared to 75 percent of those with sporadic cancer.

Early Onset Endometrial Cancer Signals Lynch Syndrome

Women who were diagnosed with endometrial cancer under the age of 50 had tumors with signs of Lynch syndrome in a significant number of cases.  Lynch syndrome or hereditary non-polyposis colon cancer (HNPCC) greatly increases the lifetime risk of both colorectal and endometrial cancer. Researchers in Australia studied tumors from 146 women who were diagnosed with endometrial cancer before the age of 51.  They stained the tumor sections for proteins expression by mismatch repair genes, a genetic mutation that leads to Lynch syndrome cancers.  They also tested tumor DNA for other changes that can identify or exclude Lynch syndrome, and reviewed family medical history where it was available. They found