临床试验 对找到治愈结直肠癌的方法至关重要。作为一个致力于支持病人、护理人员和家庭社区并赋予其权力的宣传组织，抗击大肠癌协会已与下列机构合作 COLONTOWN 提供每月一次的博客系列，强调患者需要知道的关于临床试验和最佳治疗方案的一切。 

在这个系列中，我们希望涵盖正在招募的有前途的试验，从过去的研究中吸取的教训，加入临床试验的后勤和资源，并为我们的结肠癌和直肠癌社区提供相关和及时的更新。

The first blog in this series will introduce you to our two clinical trial champions, Maia Walker, Lead Curator of the Fight Colorectal Cancer Trial Finder, and Manju George, Scientific Director of COLONTOWN. 

您是如何对临床试验产生兴趣的？

曼珠

"虽然我知道什么是非常普通的临床试验--我曾经是一名生物医学研究员，癌症研究是我工作的领域之一--但在我被诊断出患有癌症之前，我一直没有太注意它。当我从手术中恢复过来并准备接受6个月的FOLFOX治疗时，我不确定这种治疗方案是否是最适合我的。在COLONTOWN上，我看到了一个关于IDEA试验（3个月与6个月辅助化疗治疗III期CRC）的帖子，我被激起了想了解更多的兴趣。我阅读了更多相关资料，并与我的肿瘤医生进行了讨论，他建议我尝试3个月的CAPOX。 

回顾过去，我认为这是对我最好的决定。这让我可以选择对我来说化疗次数最少但最有效的方案，我相信这给我带来了最大的好处，而长期副作用最小，对此我非常感激。

随着我越来越多地参与COLONTOWN，特别是在临床试验组，Maia经常在那里发布病人感兴趣的试验信息，我开始寻找具体的理由或临床前研究，如果有的话，并发布它们。然后，我对BRAF V600E突变的转移性结直肠癌的临床试验产生了兴趣，因为这是一种特别具有侵略性的CRC，没有多少治疗选择，而且结果特别令人沮丧。现在，作为国家癌症研究所直肠肛门工作组的患者倡导者，关于临床试验的多个方面几乎每天都在我的脑海中出现。"

马亚

"在为我的朋友寻找可能的最佳治疗方法时，我得到了关于有希望但尚未成为护理标准的程序和药物的信息：它们正在进行临床试验。我了解了资格问题，临床试验是如何设计的，以及如何阅读记录。遗憾的是，我的朋友患上了第二种活动性癌症，无法参与其中。同时，我在网上论坛上分享这些信息，以便其他人可以考虑参与其中。九年前还是实验性的药物和治疗方法，现在已经成为CRC治疗标准的一部分（瑞戈非尼、TAS-102，以及针对MSI-高的CRC患者的免疫疗法）。

This is how I became connected with Tom Marsilje, scientist and stage IV CRC patient, who was starting to become an advocate too. He was the father of Fight CRC’s 审讯搜索器 和一个我永远保留在心中的朋友。"

让我们来聊一聊试验!你认为我们的社区应该知道现在有什么试验在招募？ 

马亚

"PACES (Preventing Adenomas of the Colon with Eflornithine and Sulindac, NTC# NCT01349881) is a perfect example of a trial that debunks the myth of clinical trials as the last resource. It is for patients who already had colon or rectal cancer, stage 0 to III, and who are cancer free. The goal? Help them to prevent the development of new adenomas (precancerous polyps) or a second primary cancer in the colon. From the perspective of a patient, it is a great opportunity to maybe prevent a recurrence, while receiving the best following from doctors. The trial implies taking pills (oral administration, without a ton of clinic visits) of two already approved-for-other-uses drugs, with well-known safety profiles, or maybe placebos. There are many locations where the trial is available, and the trial has been ongoing for several years. Many who are on it, even if they don’t know if they are receiving the placebo, feel empowered because they are doing their share and contributing to the research to help others."

在开始寻找试验时，您对病人有什么建议？

曼珠

"早点开始。 

When you are diagnosed, it’s a good idea to read documents like the National Comprehensive Cancer Network (NCCN) patient guide and to take your time. Initially, nothing may make sense. But over time, things will get clearer. The NCCN  lays out the different standard of care (SOC) options for your stage and type of cancer. It helps you see the potential treatments that you can have. I think this can put you in a frame of mind where you are able to think about what treatment you should consider next. Learning is an active process that can be impacted greatly by the patient’s (or caregiver’s)  state of mind. The best time to search for trials is when chemotherapy is working, when things are stable or shrinking, and you have figured out how to deal with the side-effects of the current regimen. This is the time to start reading up about clinical trials and join groups like COLONTOWN where clinical trials are discussed in the Clinical Trial groups. As you do this, it is important to figure out your goals of treatment. Everyone is aiming for a cure, but in that path what do you want for the short-term? What are your plans to get there?"

马亚

"尽早开始研究临床试验，在癌症诊断时就开始研究。屋子里最糟糕的神话是'临床试验是最后的资源'。恰恰相反，即使对于那些刚刚被诊断出来的人，对于那些即将开始一线治疗的人，对于那些处于三线治疗的人，对于所有的阶段，等等，都有临床试验。 此外，还有一些临床试验并不提供积极的疾病治疗，但可能缓解治疗带来的副作用，或帮助家庭成员检查他们是否有增加的风险。这些都是令人难以置信的重要!

临床试验可能是接受一种即将被批准的治疗的机会。对于最常见类型的癌症患者来说，临床试验使他们能够接受癌症免疫疗法这一新兴领域的新疗法。

要积极主动，即使你认为不需要，也要研究一下临床试验。"

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请继续关注更多信息!

Once a month, Maia and Manju will spend time unpacking important research trials, tips, and advice for our community.

你也可以关注Maia (@sassycell) 和 Manju (@manjuggm)以了解最新的研究和试验情况，并访问 临床试验网（ClinicalTrials.gov 了解更多关于审判的信息。

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