我们兴奋地获悉 Kite Pharma 公司昨天宣布 他们将发起 个性化细胞免疫疗法 在 2016 年底之前推出。这些疗法将针对以下领域的某些细分市场 KRAS 突变体 癌症患者群体（KRAS 突变是结直肠癌的生物标志物）。这项新技术将利用 活的免疫细胞 as the “drug.”

An upcoming announcement will provide detail about which sub-segments will be targeted and what testing will be required to know if a patient is eligible. It is important for us to highlight that the basis for Phase 1 clinical trials is usually animal model testing or preliminary findings in at most a few patients. This means that even if preliminary data look promising, they are very early and need clinical confirmation.

As discussed in our Currently Incurable Scientist Blog last January, this type of therapy enters into the ultimate areas of personalized immunotherapy. This has been explored for a number of years, for example at the National Institutes of Health (NIH) under the direction of Steven A. Rosenberg, M.D., Ph.D., Chief of the Surgery Branch at the NCI.

Realistically, it will take months to years to know how well these therapies work for trial-eligible KRAS-mutant cancer patients and multiple years before they may become available outside of a clinical trial.

The research is now being transferred for more extensive clinical trial testing through a commercialization partnership with Kite Pharma. The findings of this type of research can potentially help many people, or at least serve as foundation to continue our research initiatives.

Stay tuned! Fight Colorectal Cancer and the Currently Incurable Scientist will stay on top of the details and will, as always, explain them to you in easy-to-understand layperson language as they are announced.

 

关于博士。TOM MARSILJE

Tom Marsilje 博士是一位从事肿瘤学研究超过 20 年的科学家，患有 "目前无法治愈 "的 IV 期非多发性硬化结肠癌，并且是一名 科隆俱乐部 2016年Colondar 2.0模型。他还写了一个个人博客，讲述作为癌症患者和研究人员的交集的生活 "终极乐观的生活历险记” and posts updates to Twitter @CurrentIncurSci. As mentioned in his introductory post to this monthly column, he is a Ph.D. scientist and not a M.D. He exclusively gives his opinions on the “science” of experimental therapies – nothing written should be misinterpreted as implying medical advice.