Blood Tests for Colorectal Cancer To get more people screened, scientists are developing new methods to make colorectal cancer screening tests more accessible. Besides traditional colonoscopy and stool-based tests, researchers have discovered markers in the blood that can indicate the presence of colorectal cancer and, occasionally, precancerous polyps. These innovative blood tests are quickly gaining FDA approval and becoming more widely available to patients. Here is what you need to know if you are questioning if this type of test is a good fit for you. Pros and Cons When considering a blood test for colorectal cancer, it’s important to consider the pros and cons. Pros Here are some pros to a blood test. Simple Blood Draw The test requires a routine blood sample. No Stool Handling Unlike other non-invasive tests, you don’t need to handle or collect stool samples. Convenient There is no need for time off work or anesthesia, making it a hassle-free option. You also do not have prep or dietary changes. High Sensitivity Blood tests are highly effective at detecting colorectal cancer and have similar rates to other non-invasive tests for colorectal cancer screening. This means these tests have a high percentage of correctly identifying those who do not have colorectal cancer (Grady, 2019). Cons Here are some cons to a blood test. Limited Preventive Ability Blood tests are not as effective at identifying pre-cancerous polyps (which are crucial for prevention) vs. many of the stool-based tests like FIT or mtDNA. In addition, colonoscopy remains the only testing option that can identify and remove pre-cancerous polyps in one setting. (Ladabaum, 2018). Many medical professionals are advising patients to understand the blood test is strong in detecting or ruling out cancer, but not cancer prevention. Follow-up Colonoscopy Required Like a stool test, if the blood test results are positive, a follow-up colonoscopy is necessary to confirm the findings. Frequent Testing Needed Similar to other non-invasive screening tests, blood tests will need to be repeated every 1-3 years to maintain their effectiveness. Insurance Coverage Since blood tests for colorectal cancer are not yet universally accepted or included in screening guidelines, insurance companies may not cover the costs (American Cancer Society, 2023). Should You Consider a Blood Test for Colorectal Cancer? Discuss your screening options with your medical provider. Ask if a blood test is suitable for you. Keep in mind that a blood test will not be recommended if: You are at an increased or high risk for colorectal cancer. You or a first-degree biological family member have had previous colorectal cancer(s) or advanced adenomas/precancerous polyps. You have signs or symptoms that require immediate evaluation. Every screening test has its pros and cons, so be sure to consider all your options and choose the one that best fits your health history and your needs. What should I do if I want to do a blood test for colorectal cancer screening? Like colonoscopy and stool-based tests, blood tests for colorectal cancer screening need to be prescribed and recommended by a medical provider. To determine if you’re a good candidate for this testing option, we encourage speaking with your primary care physician, gastroenterologist, or OBGYN. Will my insurance pay for my blood test for colorectal cancer screening? If you and your medical professional agree that a blood test is a good option for your colorectal cancer screening, contact your insurance provider to ask if a blood test to screen for colorectal cancer is a covered benefit. If your insurance does not pay, you may be liable for the fees for the blood test. Consulting your medical professional via an online patient portal or by phone could help you avoid repeat visits if it’s determined the blood test is an option for you. Currently, most insurance plans do pay for colorectal cancer screening options which are in USPSTF guidelines. (At this time, blood testing is not part of the USPSTF guidelines). Some companies offering blood testing for colorectal cancer may offer free or patient assistance programs to help pay for blood testing. Guardant Access References: Grady, W. M. (2019). Emerging Blood-Based Tests for Colorectal Cancer Screening. Nature Reviews Gastroenterology & Hepatology. Retrieved from source.Ladabaum, U. (2018). Comparative Effectiveness of Colorectal Cancer Screening Tests. Annals of Internal Medicine. Retrieved from source.American Cancer Society. (2023). Colorectal Cancer Early Detection, Diagnosis, and Staging. Retrieved from source.