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  • Knowing your colorectal cancer (CRC) biomarkers can help you make well-informed decisions about how your cancer will be treated.
  • NTRK gene fusion is one of a handful of important biomarkers for CRC patients to know about.

TRK fusion cancers are caused by genomic alterations that occur when one of the neurotrophic tyrosine receptor kinase (NTRK) genes become fused, or connected, to another unrelated gene, in this case, ETV6, LMNA, or TPM3. This fusion leads to uncontrolled TRK signaling, also called overexpression of TRK fusion proteins, which may lead to cancer. NTRK gene fusions are genomic alterations (biomarkers) that lead to the production of TRK fusion proteins.

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