Fight Colorectal Cancer (Fight CRC) and the Colon Cancer Coalition (CCC) are excited to announce they are partnering to fund an innovative research grant at Mayo Clinic. Dr. Lisa Boardman, along with her team at Mayo, will be expanding a biobank (a type of biorepository that stores biological samples for use in research) to include both colorectal pre-cancer and colorectal cancer samples to better understand what leads the normal colon to transform into a polyp, and in some cases to progress to cancer.
Fight CRC’s board member Ron Doornick through the Ron and Martha Doornink Foundation provided a $150,000 contribution for this project to Fight CRC and the Colon Cancer Coalition graciously matched $50,000, donated by Dan and Paula McQuillen, who lost their son Sean in 2011 at the young age of 34 following a stage IV colon cancer diagnosis and a brief 30-day fight.
Another focus of this collaborative effort is addressing the alarming rise in colorectal cancer cases in those younger than age 50 by focusing on the differences in biology between young adult-onset colorectal cancer and older onset colorectal cancer.
The McQuillens have raised money for the Colon Cancer Coalition through an annual golf outing held in their son’s memory, hopeful one day they will make an impact on the lives and treatment for other young colorectal cancer patients. The McQuillens are eternally grateful for the care and compassion their son received at Mayo Clinic, the only medical facility that would consider treatment during his short 30-day battle with advanced-stage disease.
“Sean was a loving husband, father of two girls, son, brother, nephew, and a great friend to many. There is not a day that goes by that we do not miss his infectious smile and gentle manner,” remembers Paula McQuillen. “It is wonderful to know that our efforts and money raised is being used to help find methods to prevent and treat other young people before they reach the same circumstances as Sean. We need this research to help save other young vibrant adults from the same fate.”
Where the Research Began
This project is an extension of the Biobank for Gastrointestinal Health Research, which opened in April 2000 at the Mayo Clinic in Rochester, Minnesota, the original and largest Mayo Clinic campus.
Dr. Boardman’s earlier research set the stage for this current project. Her findings indicated that there may be important differences in biology between colorectal cancer in young adults versus older adults. Notably, their team found that telomere length (structures at the end of chromosomes, which provide protection and become shorter with age) relates to the type of damage at the molecular level in cancers.
“We found that we can trace these telomere and molecular events, and they may even be found in the normal colon and precancerous polyp. We determined that polyps that go on to transform to cancer have different telomere and genetic differences, which we believe may be good targets for early detection and preventing cancer by rerouting a polyp to molecularly resemble a polyp that will not transform to cancer,” said Dr. Boardman.
Currently, the Biobank has biospecimens from over 5500 individuals, including those who are healthy, those who have polyps, and those who have cancer. These biospecimens include blood, normal colons, colon polyps and cancers, stool for microbiome studies, and an epidemiology questionnaire.
Where Will the Research Go from Here?
Dr. Boardman and her team are now expanding their biobank to collect primary and recurrent polyps and cancers at different stages of development and in different age groups. They are also creating organoids, small living replicas of normal colons, polyps, or cancer that can be used to test drugs and the impact of genetic changes on the behavior of polyps and cancers.
They will create these organoids from human patient tissue. The organoids will be used to understand telomere length as it relates to cancer, and ultimately predict whether a polyp may turn into cancer. This would be a huge step forward in clinical care. Currently, there are no blood or tissue-based molecular tests used to tailor surveillance intervals for patients with polyps.
According to Dr. Boardman, “Because colorectal cancer and precancerous polyps are becoming more common in younger people who are not normally recommended to have colon cancer screening, it is important to identify markers that might improve our ability to identify which younger people are at risk for developing precancerous polyps and cancer.”
“The ability to determine a polyp’s risk for progression to cancer could have significant benefits for patients and the healthcare system, including reducing costs, reducing risks, and improving the use of colonoscopy. Through the support of Fight Colorectal Cancer and the Colon Cancer Coalition, we will continue our efforts to establish a pre-cancer biobank to support future studies on polyps in order to prolong health by preventing pre-malignancy in the colon.”
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